Depressed
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Depressed

› Forums › General Melanoma Community › Depressed

  • Post
    • September 28, 2015 at 6:23 pm
    Debbieamccoy
    Participant

    I was diagnosed 3b may/15. Had WLI AND CLND . Only my sentinel biopsy was positive. I had perfectly clear scans on 8/18 on 8/26! I had my first round of yervoy. One week later I started n/v went to the ER and with my history a ct was done that showed probable mets to confirmed by biopsy. All of my liver enzymes are out of range ast 76 alt 284 and allk phos 278. My LDH is 5280. I started Keytruda last week but  I saw my dr this morning and he mentioned his concern st this rapid change of events occurred . I am too has any one else been threw this , I'm discouraged but stil fighting 

Viewing 2 reply threads
  • Replies
      • September 28, 2015 at 6:29 pm
      dfeng
      Participant

      where is the met? Best wishes and pray for you. Hang in there and keep us updated!.

      • September 28, 2015 at 6:29 pm
      dfeng
      Participant

      where is the met? Best wishes and pray for you. Hang in there and keep us updated!.

      • September 28, 2015 at 6:29 pm
      dfeng
      Participant

      where is the met? Best wishes and pray for you. Hang in there and keep us updated!.

        • September 28, 2015 at 7:08 pm
        Debbieamccoy
        Participant

        Mets to liver, I just found out my LDH dropped 800 points in one week after Keytruda round one . Staying hopeful

        • September 28, 2015 at 7:08 pm
        Debbieamccoy
        Participant

        Mets to liver, I just found out my LDH dropped 800 points in one week after Keytruda round one . Staying hopeful

        • September 28, 2015 at 7:08 pm
        Debbieamccoy
        Participant

        Mets to liver, I just found out my LDH dropped 800 points in one week after Keytruda round one . Staying hopeful

        • September 28, 2015 at 7:36 pm
        tschmith
        Participant

        Yes, stay hopeful!!!!!  800 points is a big drop.  Please keep us posted.  I've had terrific results with Keytruda and I bet you will too! (My LDH dropped afer my first infusion.)  

        Best Wishes!!!!

        Terrie

         

        • September 28, 2015 at 7:36 pm
        tschmith
        Participant

        Yes, stay hopeful!!!!!  800 points is a big drop.  Please keep us posted.  I've had terrific results with Keytruda and I bet you will too! (My LDH dropped afer my first infusion.)  

        Best Wishes!!!!

        Terrie

         

        • September 28, 2015 at 7:36 pm
        tschmith
        Participant

        Yes, stay hopeful!!!!!  800 points is a big drop.  Please keep us posted.  I've had terrific results with Keytruda and I bet you will too! (My LDH dropped afer my first infusion.)  

        Best Wishes!!!!

        Terrie

         

        • September 29, 2015 at 12:49 am
        arthurjedi007
        Participant

        Sounds like the keytruda might already be helping which is great.

        One thing you can ask the doc if you look it up and decide if you want is a liver embolism. This is usually reserved for large liver tumors so maybe not right for you. Dunno. One lady on here had that done for her daughter which gave an early good response followed up by immunotherapy that helped a lot too. They can also do radiation pellets directly on the liver tumors. Both of those require no trial that I'm aware of and the doc might probably be able to do them while on keytruda. Just some thoughts you might keep in mind if needed.

        Artie

        • September 29, 2015 at 12:49 am
        arthurjedi007
        Participant

        Sounds like the keytruda might already be helping which is great.

        One thing you can ask the doc if you look it up and decide if you want is a liver embolism. This is usually reserved for large liver tumors so maybe not right for you. Dunno. One lady on here had that done for her daughter which gave an early good response followed up by immunotherapy that helped a lot too. They can also do radiation pellets directly on the liver tumors. Both of those require no trial that I'm aware of and the doc might probably be able to do them while on keytruda. Just some thoughts you might keep in mind if needed.

        Artie

        • September 29, 2015 at 12:49 am
        arthurjedi007
        Participant

        Sounds like the keytruda might already be helping which is great.

        One thing you can ask the doc if you look it up and decide if you want is a liver embolism. This is usually reserved for large liver tumors so maybe not right for you. Dunno. One lady on here had that done for her daughter which gave an early good response followed up by immunotherapy that helped a lot too. They can also do radiation pellets directly on the liver tumors. Both of those require no trial that I'm aware of and the doc might probably be able to do them while on keytruda. Just some thoughts you might keep in mind if needed.

        Artie

        • September 29, 2015 at 8:50 pm
        Debbieamccoy
        Participant

        Now my dr has decided to put me on a combo yervoy and opvido

        https://www.futureofoncology.com/opdivoyervoy-combo-could-be-new-standard-in-melanoma

        im confused because I had progression of disease with one dose of yervoy. I've researched and can't find anything about restarting yervoy 

        • September 29, 2015 at 8:50 pm
        Debbieamccoy
        Participant

        Now my dr has decided to put me on a combo yervoy and opvido

        https://www.futureofoncology.com/opdivoyervoy-combo-could-be-new-standard-in-melanoma

        im confused because I had progression of disease with one dose of yervoy. I've researched and can't find anything about restarting yervoy 

        • September 29, 2015 at 8:50 pm
        Debbieamccoy
        Participant

        Now my dr has decided to put me on a combo yervoy and opvido

        https://www.futureofoncology.com/opdivoyervoy-combo-could-be-new-standard-in-melanoma

        im confused because I had progression of disease with one dose of yervoy. I've researched and can't find anything about restarting yervoy 

        • September 30, 2015 at 1:43 am
        Bubbles
        Participant

        If you read the post I put up regarding combination therapies it should make clear the difference between single therapies vs the results when they are combined…nivo/ipi in particular.  celeste

        • September 30, 2015 at 1:43 am
        Bubbles
        Participant

        If you read the post I put up regarding combination therapies it should make clear the difference between single therapies vs the results when they are combined…nivo/ipi in particular.  celeste

        • September 30, 2015 at 1:43 am
        Bubbles
        Participant

        If you read the post I put up regarding combination therapies it should make clear the difference between single therapies vs the results when they are combined…nivo/ipi in particular.  celeste

        • September 30, 2015 at 6:09 pm
        jpg
        Participant

        Usually if you progress on one or the other (IPI or NIVO) the combination isn't usually succesful.  I would ask the doctor too about this.  Lots of toxic side effects too.  Can't you just do the NIVO?  

        • September 30, 2015 at 6:09 pm
        jpg
        Participant

        Usually if you progress on one or the other (IPI or NIVO) the combination isn't usually succesful.  I would ask the doctor too about this.  Lots of toxic side effects too.  Can't you just do the NIVO?  

        • September 30, 2015 at 8:08 pm
        Debbieamccoy
        Participant

        There are study's that show that even with progression to continue yervoy. 

        • October 1, 2015 at 9:08 pm
        tschmith
        Participant

        Debbie, 

        Did they take you off of Yervoy after one dose?

        Terrie

        • October 1, 2015 at 9:08 pm
        tschmith
        Participant

        Debbie, 

        Did they take you off of Yervoy after one dose?

        Terrie

        • October 1, 2015 at 9:08 pm
        tschmith
        Participant

        Debbie, 

        Did they take you off of Yervoy after one dose?

        Terrie

        • October 1, 2015 at 9:10 pm
        tschmith
        Participant

        I'm sorry…I reread your post and I see that you received just one dose.

        Terrie

        • October 1, 2015 at 9:10 pm
        tschmith
        Participant

        I'm sorry…I reread your post and I see that you received just one dose.

        Terrie

        • October 1, 2015 at 9:10 pm
        tschmith
        Participant

        I'm sorry…I reread your post and I see that you received just one dose.

        Terrie

        • October 2, 2015 at 2:34 am
        Debbieamccoy
        Participant

        Yes but they are restating it with nivo

        • October 2, 2015 at 2:34 am
        Debbieamccoy
        Participant

        Yes but they are restating it with nivo

        • October 2, 2015 at 2:34 am
        Debbieamccoy
        Participant

        Yes but they are restating it with nivo

        • September 30, 2015 at 8:08 pm
        Debbieamccoy
        Participant

        There are study's that show that even with progression to continue yervoy. 

        • September 30, 2015 at 8:08 pm
        Debbieamccoy
        Participant

        There are study's that show that even with progression to continue yervoy. 

        • September 30, 2015 at 6:09 pm
        jpg
        Participant

        Usually if you progress on one or the other (IPI or NIVO) the combination isn't usually succesful.  I would ask the doctor too about this.  Lots of toxic side effects too.  Can't you just do the NIVO?  

Viewing 2 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.