premedy
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premedy

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      • February 6, 2012 at 11:11 pm
      premedy
      Participant

      You seem to be asking are there any Pathway inhibitors (the FDA approved one being Zelboraf, a braf inhibitor) for Braf negative people.  Some trial options would be a MEK inhibitor or the  PI3K inhibitor (there is a MEK PI3K combo trial out there. check out http://www.clinicaltrials.gov )  Also there is a Phase III trial for the drug E7080 which has shown some progress for both Braf positive and Braf negative people. according to Keith Flaherty (Braf  Guru, MD at Harvard).  There are arms for both braf positive and braf negative.

      pat

      • February 6, 2012 at 11:11 pm
      premedy
      Participant

      You seem to be asking are there any Pathway inhibitors (the FDA approved one being Zelboraf, a braf inhibitor) for Braf negative people.  Some trial options would be a MEK inhibitor or the  PI3K inhibitor (there is a MEK PI3K combo trial out there. check out http://www.clinicaltrials.gov )  Also there is a Phase III trial for the drug E7080 which has shown some progress for both Braf positive and Braf negative people. according to Keith Flaherty (Braf  Guru, MD at Harvard).  There are arms for both braf positive and braf negative.

      pat

      • February 6, 2012 at 11:11 pm
      premedy
      Participant

      You seem to be asking are there any Pathway inhibitors (the FDA approved one being Zelboraf, a braf inhibitor) for Braf negative people.  Some trial options would be a MEK inhibitor or the  PI3K inhibitor (there is a MEK PI3K combo trial out there. check out http://www.clinicaltrials.gov )  Also there is a Phase III trial for the drug E7080 which has shown some progress for both Braf positive and Braf negative people. according to Keith Flaherty (Braf  Guru, MD at Harvard).  There are arms for both braf positive and braf negative.

      pat

      • February 1, 2012 at 10:18 pm
      premedy
      Participant

      All anyone needs to know about this guy is that on his website he sells suplements  such as organic body butter, tanning oil, and green tea sun screen (that doesn't block UV rays but claims to reflect them).  Maybe this guy would have an ounce of credibility if he wasn't hocking his unproven organic products on his website. 

      He repeatedly refers to studies, several studies, thousands of studies etc.  what studies? where is the proof?

      • February 1, 2012 at 10:18 pm
      premedy
      Participant

      All anyone needs to know about this guy is that on his website he sells suplements  such as organic body butter, tanning oil, and green tea sun screen (that doesn't block UV rays but claims to reflect them).  Maybe this guy would have an ounce of credibility if he wasn't hocking his unproven organic products on his website. 

      He repeatedly refers to studies, several studies, thousands of studies etc.  what studies? where is the proof?

      • February 1, 2012 at 10:18 pm
      premedy
      Participant

      All anyone needs to know about this guy is that on his website he sells suplements  such as organic body butter, tanning oil, and green tea sun screen (that doesn't block UV rays but claims to reflect them).  Maybe this guy would have an ounce of credibility if he wasn't hocking his unproven organic products on his website. 

      He repeatedly refers to studies, several studies, thousands of studies etc.  what studies? where is the proof?

      • June 11, 2011 at 3:16 pm
      premedy
      Participant

      Does anyone have any updates on this drug?  Scan results, side effects, success and failures etc?

      • June 11, 2011 at 3:16 pm
      premedy
      Participant

      Does anyone have any updates on this drug?  Scan results, side effects, success and failures etc?

      • May 19, 2011 at 9:25 pm
      premedy
      Participant

      great post! You have such an amazing attitude and approach.  What a great influence you will be on this board.

      pat

      • February 6, 2012 at 8:21 pm
      premedy
      Participant

      Frank,

       Why do you say that early Braf inhibitors such as Zelboraf have problems with their effectiveness?  I think that despite the fact they don't last long for the majority of responders (there are some durable responses) they have a place because no other drug can reduce tumor load as quickly and in such a high percentage of braf+ patients.  In some patients it can lower tumor burden enough for surgery to be an option as well. 

      • February 6, 2012 at 8:21 pm
      premedy
      Participant

      Frank,

       Why do you say that early Braf inhibitors such as Zelboraf have problems with their effectiveness?  I think that despite the fact they don't last long for the majority of responders (there are some durable responses) they have a place because no other drug can reduce tumor load as quickly and in such a high percentage of braf+ patients.  In some patients it can lower tumor burden enough for surgery to be an option as well. 

      • February 6, 2012 at 8:21 pm
      premedy
      Participant

      Frank,

       Why do you say that early Braf inhibitors such as Zelboraf have problems with their effectiveness?  I think that despite the fact they don't last long for the majority of responders (there are some durable responses) they have a place because no other drug can reduce tumor load as quickly and in such a high percentage of braf+ patients.  In some patients it can lower tumor burden enough for surgery to be an option as well. 

      • November 7, 2011 at 9:27 pm
      premedy
      Participant

      hey lisa,

       you know what I actually watched that a while back but didn't even realize he spoke about long term responders. I am going to check it out again.  I am thinking that if it works once then you could always use it again if the Mel comes back.

      • November 7, 2011 at 9:27 pm
      premedy
      Participant

      hey lisa,

       you know what I actually watched that a while back but didn't even realize he spoke about long term responders. I am going to check it out again.  I am thinking that if it works once then you could always use it again if the Mel comes back.

      • November 7, 2011 at 9:27 pm
      premedy
      Participant

      hey lisa,

       you know what I actually watched that a while back but didn't even realize he spoke about long term responders. I am going to check it out again.  I am thinking that if it works once then you could always use it again if the Mel comes back.

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