keesvp

Hi Maureen,

My wife Mariëtte is in the same situation as your husband, stage IV acral lentiginous, with mets in her lungs. She is in an anti-PD1 trial at UCSF in San Francisco. After 24 weeks she seems to be partially responsive in that the tumors stopped growing. It is very unlikely to be fully responsive to anti-PD1 with acral lentiginous, because it seems that there is no PD-L1 expression in that type, which recently was discovered to be an indication for responsiveness to anti-PD1. 

Hi Maureen,

My wife Mariëtte is in the same situation as your husband, stage IV acral lentiginous, with mets in her lungs. She is in an anti-PD1 trial at UCSF in San Francisco. After 24 weeks she seems to be partially responsive in that the tumors stopped growing. It is very unlikely to be fully responsive to anti-PD1 with acral lentiginous, because it seems that there is no PD-L1 expression in that type, which recently was discovered to be an indication for responsiveness to anti-PD1. 

Hi Maureen,

My wife Mariëtte is in the same situation as your husband, stage IV acral lentiginous, with mets in her lungs. She is in an anti-PD1 trial at UCSF in San Francisco. After 24 weeks she seems to be partially responsive in that the tumors stopped growing. It is very unlikely to be fully responsive to anti-PD1 with acral lentiginous, because it seems that there is no PD-L1 expression in that type, which recently was discovered to be an indication for responsiveness to anti-PD1. 

Mariëtte, my wife. At UCSF, like you. First infusion 4/11. No clear side effects until now. Suddenly seems to have some kind of pollen allergy though.

Kees

Mariëtte, my wife. At UCSF, like you. First infusion 4/11. No clear side effects until now. Suddenly seems to have some kind of pollen allergy though.

Kees

Mariëtte, my wife. At UCSF, like you. First infusion 4/11. No clear side effects until now. Suddenly seems to have some kind of pollen allergy though.

Kees

Thanks for your good thoughts Maureen. Mariëtte has not been on any other treatments. I just wanted to share that info. Most melanoma patients regard getting in a PD1 trial as the holy grail. For some it really is a miracle cure. I wish you both the very best. There's a lot going on in melanoma research and more reason for hope than ever before.

Kees

Thanks for your good thoughts Maureen. Mariëtte has not been on any other treatments. I just wanted to share that info. Most melanoma patients regard getting in a PD1 trial as the holy grail. For some it really is a miracle cure. I wish you both the very best. There's a lot going on in melanoma research and more reason for hope than ever before.

Kees

Thanks for your good thoughts Maureen. Mariëtte has not been on any other treatments. I just wanted to share that info. Most melanoma patients regard getting in a PD1 trial as the holy grail. For some it really is a miracle cure. I wish you both the very best. There's a lot going on in melanoma research and more reason for hope than ever before.

Kees