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Zometa or Denosumab
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Zometa or Denosumab

› Forums › General Melanoma Community › Zometa or Denosumab

  • Post
    • March 10, 2022 at 12:40 pm
    Daisy2018
    Participant
      Hello fellow melanoma fighters,
      I thought I can ask.
      My bones have been giving up on me lately with compression fracture in my L3 from Mets.
      I had asked my doctor for Zometa, since I remember reading here it helps with bones support. Does anybody have experience with it?

      Optivo/Yervoy they make me already so stiff. I had my 4 th infusion couple days ago and feel my knees, shoulders are so stiff. I wonder if I will fell better getting Zometa or there are some serious side effects which would be too much to add to the plate with ipi/nivo, radiation, bones biopsies now?
      Want get better not worse! If it makes any sense?! Thanks a lot.

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    • Replies
        • March 11, 2022 at 12:47 am
        Edwin
        Participant
          I received Zometa for perhaps 2 years while receiving immunotherapy for stage 4 melanoma. I did not ask for it. My oncologist chose it. I did not notice any problem with it. My oncologist stopped giving Zometa to me, when my bones healed and she decided its risks exceeded its benefits.
          • March 11, 2022 at 6:51 pm
          Daisy2018
          Participant
            Thank you Edwin!
            Oh, you didn’t have many side effects to Zometa?! I read lots of people saying it’s a worst medicine ever with flu like symptoms, bones, joints pain, feeling like being hit by the brick wall.
            I can’t afford to feel worse than I feel. I mean there always can be worse, right?! I m terrified to get all these terrible side effects on a top of weakness, nausea, pain.
            Our story sounds somewhat alike with lots of disease in bones involved.
            The immunotherapy treatment had worked for you. I m still hoping it will work for me too and it just taking it’s sweet time.
            It’s nice you are around responding and keeping peoples hope and spirit up.
            It’s very easy to lose hope in this situation. Thank you for being here!
            Daisy….
            • March 11, 2022 at 9:35 pm
            ThinkingPositive
            Participant
              Hi Daisy, I was on Zometa initially with my first infusion of pembrolizumab and immediately ran fevers and got joint pain. Doctor thought it was the Zometa so after steroids and a rest I started on Xgeva. I thank pembrolizumab for my side effects (arthralgia, diarrhea, weight loss, itchyness). By the way, I just went to every three months for the Xgeva injections which she is keeping me on mostly for osteoporosis as my bone mets has healed.
              • March 12, 2022 at 11:58 am
              Daisy2018
              Participant
                Thank you ThinkingPositive for responding!

                I didn’t know there is something else besides the two medications I mentioned previously.

                I need to do my research. It sounds like a serious treatment. One more heavy duty medication on a top of ipi/nivo I m getting now. Definitely not like vitamins infusion.
                I m terrified of feeling worse then I m now.
                Daisy…

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