I've updated my profile to give more in depth info but here's the summary. I was diagnosed at stage 4 about this time last year with numerous nodules and malignancies in my lungs. prior to that had been stage 3 for about 10 months when an inguinal lymph node was found to be malignant, 16 years after a primary on my calf. had LND, 17 lymph nodes were removed, only the 1 was malignant. had high dose radiation on that area after the surgery. 10 IV Interferon treatments Nov 2011.
I've updated my profile to give more in depth info but here's the summary. I was diagnosed at stage 4 about this time last year with numerous nodules and malignancies in my lungs. prior to that had been stage 3 for about 10 months when an inguinal lymph node was found to be malignant, 16 years after a primary on my calf. had LND, 17 lymph nodes were removed, only the 1 was malignant. had high dose radiation on that area after the surgery. 10 IV Interferon treatments Nov 2011. Feb of 2012 had breathing problems, subsequent scans showed info in first line of this update. Began Zelboraf and hi dose radiation in late feb of last year. had some dosage adjustments intially, ended up taking 3 and 3. Scans were good until Feb of this year when one remaining node that had been the largest began to growand was joined by a 2nd node of the same size in the same lung. My oncologists locally and at OHSU referred me to a Phase I clinical trial at OHSU and have been in the process of being screened for that, more screening this week but i'm scheduled to begin the new treatments a week from this wednesday. The trial is being conducted at the OHSU Knight Cancer Institute. Title is "EMR200066_006: an Open-Label, Phase Ib Dose Escalation Trial of Oral Combination Therapy with MSC1936369B and SAR 245409 in Subjects with Locally Advanced or Metastic Solid Tumors. " the Sponsor is EMD Serono, inc. the drugs are an MEK inhibitor and a combination P13K and mTOR inhibitors.
This trial is also enrolling patients with corresponding breast cancer, Non Small Cell Lung Cancer and Colorectal Cancer. I'm feeling pretty lucky to get into this trial and will post how it rolls out.
I had hoped to be one of those long term responders to Zelboraf because it worked so quikcly and so well for me, I had very few of the side effects, all of which were quite livable but it was not to be.
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