› Forums › General Melanoma Community › Zelboraf
- This topic has 12 replies, 3 voices, and was last updated 9 years, 6 months ago by
uccio2014.
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- October 20, 2014 at 12:41 pm
Hello all,
it is the first time i write here but i follow the site dialy.
Here my question:
there is someone under zelboraf for a long period?
any ned? and if so after how long? and for how long?
how did you detect it had stop to work?
Praying to go on reading about all of you for years
Antonio
- Replies
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- October 22, 2014 at 4:54 am
Hi, I was on Zelboraf two years ago and I had numerous tumors when I started. I stayed on Z for 13 months. Like I said, I had a lot of tumors, and after a few months, they were all gone! But the average is about 6-8 months. I actually saw a women in a group I'm in today who is still on Zelboraf for 4.5 years! I've also seen people on forums here before of 2 years plus as well.
The side effects initially can be tough: skin rash, sore feet, and sore joints, and especially sun exposure. You must be extremely careful to stay out of the sunlight. If you are in the sun, you must be covered up.
Good luck.
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- October 22, 2014 at 8:40 am
Hello and ty for your answer.
My wife started z on august (stage IV with mets in lungs liver intestine adn bones) and on the first scan mostly of mets disappears and all strinks.
We are really worry Z will stop to work and to catch this stop late (if i do not misandestud her doctor said only tac can sais that z stopped work and next tac is in 3 mounth).
Any suggestion on early signal Z stopped to work?
Thank's again for your help.
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- October 22, 2014 at 8:40 am
Hello and ty for your answer.
My wife started z on august (stage IV with mets in lungs liver intestine adn bones) and on the first scan mostly of mets disappears and all strinks.
We are really worry Z will stop to work and to catch this stop late (if i do not misandestud her doctor said only tac can sais that z stopped work and next tac is in 3 mounth).
Any suggestion on early signal Z stopped to work?
Thank's again for your help.
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- October 22, 2014 at 8:40 am
Hello and ty for your answer.
My wife started z on august (stage IV with mets in lungs liver intestine adn bones) and on the first scan mostly of mets disappears and all strinks.
We are really worry Z will stop to work and to catch this stop late (if i do not misandestud her doctor said only tac can sais that z stopped work and next tac is in 3 mounth).
Any suggestion on early signal Z stopped to work?
Thank's again for your help.
-
- October 22, 2014 at 4:54 am
Hi, I was on Zelboraf two years ago and I had numerous tumors when I started. I stayed on Z for 13 months. Like I said, I had a lot of tumors, and after a few months, they were all gone! But the average is about 6-8 months. I actually saw a women in a group I'm in today who is still on Zelboraf for 4.5 years! I've also seen people on forums here before of 2 years plus as well.
The side effects initially can be tough: skin rash, sore feet, and sore joints, and especially sun exposure. You must be extremely careful to stay out of the sunlight. If you are in the sun, you must be covered up.
Good luck.
-
- October 22, 2014 at 4:54 am
Hi, I was on Zelboraf two years ago and I had numerous tumors when I started. I stayed on Z for 13 months. Like I said, I had a lot of tumors, and after a few months, they were all gone! But the average is about 6-8 months. I actually saw a women in a group I'm in today who is still on Zelboraf for 4.5 years! I've also seen people on forums here before of 2 years plus as well.
The side effects initially can be tough: skin rash, sore feet, and sore joints, and especially sun exposure. You must be extremely careful to stay out of the sunlight. If you are in the sun, you must be covered up.
Good luck.
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- October 24, 2014 at 2:19 pm
Hi Antonio,
I was on Zelbarof for nearly a year, and responded well to some brain mets and completely to 3 lung mets. Eventually I developed new brain mets and was switched to Tafinlar/Mekinist as soon as it was FDA approved. Unfortunately it did not work for me past a few months when I developed several very large brain mets. This is the biggest challenge with the BRAF inhibitors, the Brain Blood Barrier. In my research and experience, these therapies just do not work up in the brain, completely different mechanism.
As far as side effects, I suffered every single Zelbarof side effect one possibly could. It was no fun at all. However, when switched to Taf/Mek all those effects went away and I did not develop new ones from the new meds.
Given the choice, if you are going the BRAF inhibitor route, maybe see if you are a candidate for Taf/Mek. It's a heckuva lot less pills and at least in my case, a heckuva lot less side effects.
Wishing you the best of health,
kali-
- October 27, 2014 at 8:57 am
Hi Kalisama,
fortunatelly at now my wife has not brain mets, Z looks working fine, but we are just in the 3th month.
and also side effect was limited (except two time we had to stop terapy).
Sorry to listen it did not work to you but i hope you fonded a good option.
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- October 27, 2014 at 8:57 am
Hi Kalisama,
fortunatelly at now my wife has not brain mets, Z looks working fine, but we are just in the 3th month.
and also side effect was limited (except two time we had to stop terapy).
Sorry to listen it did not work to you but i hope you fonded a good option.
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- October 27, 2014 at 8:57 am
Hi Kalisama,
fortunatelly at now my wife has not brain mets, Z looks working fine, but we are just in the 3th month.
and also side effect was limited (except two time we had to stop terapy).
Sorry to listen it did not work to you but i hope you fonded a good option.
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- October 24, 2014 at 2:19 pm
Hi Antonio,
I was on Zelbarof for nearly a year, and responded well to some brain mets and completely to 3 lung mets. Eventually I developed new brain mets and was switched to Tafinlar/Mekinist as soon as it was FDA approved. Unfortunately it did not work for me past a few months when I developed several very large brain mets. This is the biggest challenge with the BRAF inhibitors, the Brain Blood Barrier. In my research and experience, these therapies just do not work up in the brain, completely different mechanism.
As far as side effects, I suffered every single Zelbarof side effect one possibly could. It was no fun at all. However, when switched to Taf/Mek all those effects went away and I did not develop new ones from the new meds.
Given the choice, if you are going the BRAF inhibitor route, maybe see if you are a candidate for Taf/Mek. It's a heckuva lot less pills and at least in my case, a heckuva lot less side effects.
Wishing you the best of health,
kali -
- October 24, 2014 at 2:19 pm
Hi Antonio,
I was on Zelbarof for nearly a year, and responded well to some brain mets and completely to 3 lung mets. Eventually I developed new brain mets and was switched to Tafinlar/Mekinist as soon as it was FDA approved. Unfortunately it did not work for me past a few months when I developed several very large brain mets. This is the biggest challenge with the BRAF inhibitors, the Brain Blood Barrier. In my research and experience, these therapies just do not work up in the brain, completely different mechanism.
As far as side effects, I suffered every single Zelbarof side effect one possibly could. It was no fun at all. However, when switched to Taf/Mek all those effects went away and I did not develop new ones from the new meds.
Given the choice, if you are going the BRAF inhibitor route, maybe see if you are a candidate for Taf/Mek. It's a heckuva lot less pills and at least in my case, a heckuva lot less side effects.
Wishing you the best of health,
kali
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