Yevoy + Keytruda combo

Hi Steve,

If i were in your shoes, i will do combo yervoy/keytruda either you are braf pos. Or neg.

Braf combo just in case your tumor burden is too high, otherwise inmunotheraphy is better option with no doubt

Hi Steve,

If i were in your shoes, i will do combo yervoy/keytruda either you are braf pos. Or neg.

Braf combo just in case your tumor burden is too high, otherwise inmunotheraphy is better option with no doubt

Hi Steve,

If i were in your shoes, i will do combo yervoy/keytruda either you are braf pos. Or neg.

Braf combo just in case your tumor burden is too high, otherwise inmunotheraphy is better option with no doubt

Hey Steve,

I've not heard of an ipilimumab (Yervoy) and Keytruda (previously named Pembrolizumab, the Merck anti-PD1 product) expanded access trial….though there may be one.  There is one currently ongoing in which ipi (Yervoy) is combined with Nivolumab (the BMS anti-PD1 product).  At any rate, researchers have generally reported that they believe both of the anti-PD1 products work very similarly and equally well.  Keytruda is currently FDA approved for melanoma patients who have progressed on ipi and, if BRAF postive, on BRAF inhibitors as well.  The combination of Nivo and ipi is showing very good results…side effects are more than when taking either ipi or nivo alone, but docs are learning how to manage them better and have flipped the dosages from some of the earlier trials…now giving a smaller dose of ipi and a larger dose of nivo than what had been given in intial studies. 

Perhaps some generally info will help you…

Here is some background info on anti-PD1:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/04/background-and-latest-info-on-anti-pd1.html

Here is a report that shows results from ipi/nivo, nivo, and pembro alone:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/nivoipi-combo-nivo-vs-pembro-pd-l1.html

Here is what a researcher reports on various combinations with ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/09/weber-presentation-on-present-ipi.html

A report on an early ipi/nivo combo:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/06/for-melanoma-ipi-and-nivolumab-bms-anti.html

And finally, some general info about what being BRAF positive means, BRAF drugs, and how to make them work better when combined with MEK:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html

Hope that helps.  Wishing you my best.  Celeste

Hey Steve,

I've not heard of an ipilimumab (Yervoy) and Keytruda (previously named Pembrolizumab, the Merck anti-PD1 product) expanded access trial….though there may be one.  There is one currently ongoing in which ipi (Yervoy) is combined with Nivolumab (the BMS anti-PD1 product).  At any rate, researchers have generally reported that they believe both of the anti-PD1 products work very similarly and equally well.  Keytruda is currently FDA approved for melanoma patients who have progressed on ipi and, if BRAF postive, on BRAF inhibitors as well.  The combination of Nivo and ipi is showing very good results…side effects are more than when taking either ipi or nivo alone, but docs are learning how to manage them better and have flipped the dosages from some of the earlier trials…now giving a smaller dose of ipi and a larger dose of nivo than what had been given in intial studies. 

Perhaps some generally info will help you…

Here is some background info on anti-PD1:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/04/background-and-latest-info-on-anti-pd1.html

Here is a report that shows results from ipi/nivo, nivo, and pembro alone:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/nivoipi-combo-nivo-vs-pembro-pd-l1.html

Here is what a researcher reports on various combinations with ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/09/weber-presentation-on-present-ipi.html

A report on an early ipi/nivo combo:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/06/for-melanoma-ipi-and-nivolumab-bms-anti.html

And finally, some general info about what being BRAF positive means, BRAF drugs, and how to make them work better when combined with MEK:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html

Hope that helps.  Wishing you my best.  Celeste

Hey Steve,

I've not heard of an ipilimumab (Yervoy) and Keytruda (previously named Pembrolizumab, the Merck anti-PD1 product) expanded access trial….though there may be one.  There is one currently ongoing in which ipi (Yervoy) is combined with Nivolumab (the BMS anti-PD1 product).  At any rate, researchers have generally reported that they believe both of the anti-PD1 products work very similarly and equally well.  Keytruda is currently FDA approved for melanoma patients who have progressed on ipi and, if BRAF postive, on BRAF inhibitors as well.  The combination of Nivo and ipi is showing very good results…side effects are more than when taking either ipi or nivo alone, but docs are learning how to manage them better and have flipped the dosages from some of the earlier trials…now giving a smaller dose of ipi and a larger dose of nivo than what had been given in intial studies. 

Perhaps some generally info will help you…

Here is some background info on anti-PD1:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/04/background-and-latest-info-on-anti-pd1.html

Here is a report that shows results from ipi/nivo, nivo, and pembro alone:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/07/nivoipi-combo-nivo-vs-pembro-pd-l1.html

Here is what a researcher reports on various combinations with ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/09/weber-presentation-on-present-ipi.html

A report on an early ipi/nivo combo:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/06/for-melanoma-ipi-and-nivolumab-bms-anti.html

And finally, some general info about what being BRAF positive means, BRAF drugs, and how to make them work better when combined with MEK:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html

Hope that helps.  Wishing you my best.  Celeste

Hi Steve 2142, you could also go and look at (Tim-MRF) and his posts. Go back to 4/20/2014 and 5/20 2014 where he talked about expanded access with Merck's Pd-1 drug and Bristol Myer Squibb's PD-1. I would also recommend the Pd-1 drugs if you can get access!!!! Best of luck!!!! Ed

Hi Steve 2142, you could also go and look at (Tim-MRF) and his posts. Go back to 4/20/2014 and 5/20 2014 where he talked about expanded access with Merck's Pd-1 drug and Bristol Myer Squibb's PD-1. I would also recommend the Pd-1 drugs if you can get access!!!! Best of luck!!!! Ed

Hi Steve 2142, you could also go and look at (Tim-MRF) and his posts. Go back to 4/20/2014 and 5/20 2014 where he talked about expanded access with Merck's Pd-1 drug and Bristol Myer Squibb's PD-1. I would also recommend the Pd-1 drugs if you can get access!!!! Best of luck!!!! Ed

I am braf pos and did tainlar and mek  for 6 months tIpi and now as of Oct on Ketruda

I am braf pos and did tainlar and mek  for 6 months tIpi and now as of Oct on Ketruda

I am braf pos and did tainlar and mek  for 6 months tIpi and now as of Oct on Ketruda