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Yervoy / PD 1 trial

Forums General Melanoma Community Yervoy / PD 1 trial

  • Post
    ad2424
    Participant

      Hello everyone

      Is anyone on this trial at Yale or Sloan, or does anyone know how it is going?

      Hello everyone

      Is anyone on this trial at Yale or Sloan, or does anyone know how it is going?

    Viewing 5 reply threads
    • Replies
        MariaH
        Participant

          I don't know of anybody off hand, but I hope you get some replies.  We are looking to get Dave into this trial after he gets off of the steroids.

          Best wishes,

          Maria

            NYKaren
            Participant

              pushing this back to page 1—I'm sure this trial is of interest to many of us. I do know that both of my docs (one each @ both hospitals) are  involved in the trial and are quite enthusiastic about Anti PD1.

              MariaH
              Participant

                Thank you for that Karen.  It seems that with all the hype about the anti-pd1, there isn't alot of people out there on them.

                MariaH
                Participant

                  Thank you for that Karen.  It seems that with all the hype about the anti-pd1, there isn't alot of people out there on them.

                  MariaH
                  Participant

                    Thank you for that Karen.  It seems that with all the hype about the anti-pd1, there isn't alot of people out there on them.

                    NYKaren
                    Participant

                      I know, Maria.  How can doctors be so excited about a treatment that nobody seems to be on?  SOMEONE has to be doing the trials, right?

                      NYKaren
                      Participant

                        I know, Maria.  How can doctors be so excited about a treatment that nobody seems to be on?  SOMEONE has to be doing the trials, right?

                        NYKaren
                        Participant

                          I know, Maria.  How can doctors be so excited about a treatment that nobody seems to be on?  SOMEONE has to be doing the trials, right?

                          NYKaren
                          Participant

                            pushing this back to page 1—I'm sure this trial is of interest to many of us. I do know that both of my docs (one each @ both hospitals) are  involved in the trial and are quite enthusiastic about Anti PD1.

                            NYKaren
                            Participant

                              pushing this back to page 1—I'm sure this trial is of interest to many of us. I do know that both of my docs (one each @ both hospitals) are  involved in the trial and are quite enthusiastic about Anti PD1.

                            MariaH
                            Participant

                              I don't know of anybody off hand, but I hope you get some replies.  We are looking to get Dave into this trial after he gets off of the steroids.

                              Best wishes,

                              Maria

                              MariaH
                              Participant

                                I don't know of anybody off hand, but I hope you get some replies.  We are looking to get Dave into this trial after he gets off of the steroids.

                                Best wishes,

                                Maria

                                JerryfromFauq
                                Participant

                                  Things often get slow on the weekends.  Do rremember that you asked abut a specifi trial an specifi locations, not bout people that have tried or am  now trying PD-1 otherwise.  (I would like to hear more about the trial to.)

                                    JerNYC
                                    Participant

                                      I was on the anti-PD-1 trial until about a month ago when my scans showed quite a lot of progression.

                                      I immediately went onto Ipi as my oncologist believed that such a course of action would be broadly equivalent to being on the combined trial, because anti-PD-1 stays on the receptors for some period of time quite longer than the blood half-life would indicate (I believe I was told 3-6 months). I had my second Ipi infusion last week.

                                      Maybe (and this is just supposition) the reason for so little information out there on the combined trial are the tiny patient numbers involved. In my case I have had a number of questions about actual or likely side effects from the combination (if indeed what I'm doing can be deemed to be akin to the combo)  and the answer I generally get back is that the "n" is too small at this stage to draw conclusions. The only more specific piece of information I received concerned the ALC. When my ALC dipped last week (not at infusion time but a few days afterwards – I had to have extra bloodwork due to a separate complication) my Dr told me that they have observed some modulation of ALC in patients on the combined trial, and they believe it is the result of the anti-PD-1. He told me not to be concerned just yet.

                                      From my perspective I feel like I am experiencing a greater number and/or intensity of side effects now than I was when I was on anti-PD-1. I guess it could also be symptoms of disease progression, but trying to stay optimistic for now that it is side effects.

                                      J

                                      JerNYC
                                      Participant

                                        I was on the anti-PD-1 trial until about a month ago when my scans showed quite a lot of progression.

                                        I immediately went onto Ipi as my oncologist believed that such a course of action would be broadly equivalent to being on the combined trial, because anti-PD-1 stays on the receptors for some period of time quite longer than the blood half-life would indicate (I believe I was told 3-6 months). I had my second Ipi infusion last week.

                                        Maybe (and this is just supposition) the reason for so little information out there on the combined trial are the tiny patient numbers involved. In my case I have had a number of questions about actual or likely side effects from the combination (if indeed what I'm doing can be deemed to be akin to the combo)  and the answer I generally get back is that the "n" is too small at this stage to draw conclusions. The only more specific piece of information I received concerned the ALC. When my ALC dipped last week (not at infusion time but a few days afterwards – I had to have extra bloodwork due to a separate complication) my Dr told me that they have observed some modulation of ALC in patients on the combined trial, and they believe it is the result of the anti-PD-1. He told me not to be concerned just yet.

                                        From my perspective I feel like I am experiencing a greater number and/or intensity of side effects now than I was when I was on anti-PD-1. I guess it could also be symptoms of disease progression, but trying to stay optimistic for now that it is side effects.

                                        J

                                        JerNYC
                                        Participant

                                          I was on the anti-PD-1 trial until about a month ago when my scans showed quite a lot of progression.

                                          I immediately went onto Ipi as my oncologist believed that such a course of action would be broadly equivalent to being on the combined trial, because anti-PD-1 stays on the receptors for some period of time quite longer than the blood half-life would indicate (I believe I was told 3-6 months). I had my second Ipi infusion last week.

                                          Maybe (and this is just supposition) the reason for so little information out there on the combined trial are the tiny patient numbers involved. In my case I have had a number of questions about actual or likely side effects from the combination (if indeed what I'm doing can be deemed to be akin to the combo)  and the answer I generally get back is that the "n" is too small at this stage to draw conclusions. The only more specific piece of information I received concerned the ALC. When my ALC dipped last week (not at infusion time but a few days afterwards – I had to have extra bloodwork due to a separate complication) my Dr told me that they have observed some modulation of ALC in patients on the combined trial, and they believe it is the result of the anti-PD-1. He told me not to be concerned just yet.

                                          From my perspective I feel like I am experiencing a greater number and/or intensity of side effects now than I was when I was on anti-PD-1. I guess it could also be symptoms of disease progression, but trying to stay optimistic for now that it is side effects.

                                          J

                                        JerryfromFauq
                                        Participant

                                          Things often get slow on the weekends.  Do rremember that you asked abut a specifi trial an specifi locations, not bout people that have tried or am  now trying PD-1 otherwise.  (I would like to hear more about the trial to.)

                                          JerryfromFauq
                                          Participant

                                            Things often get slow on the weekends.  Do rremember that you asked abut a specifi trial an specifi locations, not bout people that have tried or am  now trying PD-1 otherwise.  (I would like to hear more about the trial to.)

                                        Viewing 5 reply threads
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