Ugh! After 30 rounds of Keytruda, a new tumor has developed.

If you do a search on YouTube for dr. Jim Allison immune checkpoint blockade from Berkeley speech, you will get a video from several months ago where dr Allison talks about the current state of immunotherapy and there is a section where he talks about pd-1 drugs and progression after months of response. IT seems to be a real concern yet those that respond to Ipi long term do not relapse!!!! THe video is a little hard to follow at times do to the fact he is talking to researchers I believe. Best wishes!!!!!Ed

If you do a search on YouTube for dr. Jim Allison immune checkpoint blockade from Berkeley speech, you will get a video from several months ago where dr Allison talks about the current state of immunotherapy and there is a section where he talks about pd-1 drugs and progression after months of response. IT seems to be a real concern yet those that respond to Ipi long term do not relapse!!!! THe video is a little hard to follow at times do to the fact he is talking to researchers I believe. Best wishes!!!!!Ed

If you do a search on YouTube for dr. Jim Allison immune checkpoint blockade from Berkeley speech, you will get a video from several months ago where dr Allison talks about the current state of immunotherapy and there is a section where he talks about pd-1 drugs and progression after months of response. IT seems to be a real concern yet those that respond to Ipi long term do not relapse!!!! THe video is a little hard to follow at times do to the fact he is talking to researchers I believe. Best wishes!!!!!Ed

From prior experience, MDA will only harvest on site.

From prior experience, MDA will only harvest on site.

From prior experience, MDA will only harvest on site.

Hi Anonymous,

I am sorry to hear of your situation, and I can relate since it is similar to my own. I was on pembro for over a year. My mets had been stable almost the entire time, and my oncologist believed they were all just scar tissue. We discontinued the pembro but a scan 5 months later revealed progression.

We tried a phase 1 trial combining OX-40 with atezolizumab (anti-PD-L1). A scan 6 weeks later revealed significant disease proliferation (small intestine, heart lymph nodes, chest wall, liver, lung and sub-q's).

Ironically, my onc said the trial was for people that had progressed on anti-PD-1. But in my case it seems like it just pissed my cancer off.

So now I am flying back to Seattle, having just been to MDA for a second opinion. They are saying the same thing: TIL.

I hope this helps and I wish you the best.

– Paul

Hi Anonymous,

I am sorry to hear of your situation, and I can relate since it is similar to my own. I was on pembro for over a year. My mets had been stable almost the entire time, and my oncologist believed they were all just scar tissue. We discontinued the pembro but a scan 5 months later revealed progression.

We tried a phase 1 trial combining OX-40 with atezolizumab (anti-PD-L1). A scan 6 weeks later revealed significant disease proliferation (small intestine, heart lymph nodes, chest wall, liver, lung and sub-q's).

Ironically, my onc said the trial was for people that had progressed on anti-PD-1. But in my case it seems like it just pissed my cancer off.

So now I am flying back to Seattle, having just been to MDA for a second opinion. They are saying the same thing: TIL.

I hope this helps and I wish you the best.

– Paul

Hi Anonymous,

I am sorry to hear of your situation, and I can relate since it is similar to my own. I was on pembro for over a year. My mets had been stable almost the entire time, and my oncologist believed they were all just scar tissue. We discontinued the pembro but a scan 5 months later revealed progression.

We tried a phase 1 trial combining OX-40 with atezolizumab (anti-PD-L1). A scan 6 weeks later revealed significant disease proliferation (small intestine, heart lymph nodes, chest wall, liver, lung and sub-q's).

Ironically, my onc said the trial was for people that had progressed on anti-PD-1. But in my case it seems like it just pissed my cancer off.

So now I am flying back to Seattle, having just been to MDA for a second opinion. They are saying the same thing: TIL.

I hope this helps and I wish you the best.

– Paul

My husband was diagnosed also from healthy to stage 4 in march 2012. He did brain radiation and yervoy, which kept him stable for 5 months then had surgery for tumor in small bowel. Then we got on the anti-pd1 trial in february 2013 and he got i believe 60 or more doses when two new tumors showed up on his left and right thighs. We chose to go into another trial combining anti-pd1 with dynavex’s sd-101. He just had scans so we will know soon results, but since we can feel the new tumors they have gotten smaller since starting. Side effects are flu like. Fevers chills fatigue not feeling well, which is a bummer considering on anti-pd1 alone he had no side effects except his adrenal gland stopped working. But it has seemed to induce another immune response so far.Hes only the 5th person at u.c.l.a. on this trial.

My husband was diagnosed also from healthy to stage 4 in march 2012. He did brain radiation and yervoy, which kept him stable for 5 months then had surgery for tumor in small bowel. Then we got on the anti-pd1 trial in february 2013 and he got i believe 60 or more doses when two new tumors showed up on his left and right thighs. We chose to go into another trial combining anti-pd1 with dynavex’s sd-101. He just had scans so we will know soon results, but since we can feel the new tumors they have gotten smaller since starting. Side effects are flu like. Fevers chills fatigue not feeling well, which is a bummer considering on anti-pd1 alone he had no side effects except his adrenal gland stopped working. But it has seemed to induce another immune response so far.Hes only the 5th person at u.c.l.a. on this trial.

My husband was diagnosed also from healthy to stage 4 in march 2012. He did brain radiation and yervoy, which kept him stable for 5 months then had surgery for tumor in small bowel. Then we got on the anti-pd1 trial in february 2013 and he got i believe 60 or more doses when two new tumors showed up on his left and right thighs. We chose to go into another trial combining anti-pd1 with dynavex’s sd-101. He just had scans so we will know soon results, but since we can feel the new tumors they have gotten smaller since starting. Side effects are flu like. Fevers chills fatigue not feeling well, which is a bummer considering on anti-pd1 alone he had no side effects except his adrenal gland stopped working. But it has seemed to induce another immune response so far.Hes only the 5th person at u.c.l.a. on this trial.