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Tafinlar/Mekinist Combo cardiac side effects

Forums General Melanoma Community Tafinlar/Mekinist Combo cardiac side effects

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      I was diagnosed with Stage 4 Melanoma in 8/2017. I have mets to multiple lymph nodes. I have been on the Tafinlar/Mekinist Combo since then and have responded very well. Mosty all of the lymphy nodes are now within normal limits. The side effects have been difficult and many. I am on intermittent dosing. In December of 2019 I was hospitalized for congestive heart failure. I was taken off the Mekinist as that seems to be the culprit. After consultation with a Melanoma specialist, I cannot resume the Mekinist until I have an echocardigram that is within normal limits. With the elimination of the Mekinist, the side effects of the Tafinlar seem to be more intense (nausea, vomiting, diarrhea, chills and now intense joint pain). I learned that the combo of the two drugs helps to control their toxicity.
      Although the dosage of Tafinlar has been reduced, I still have significan discomfort from the side effects. My quality of llife.\ is not where I would like it to be. Anyone else develop cardiac problems with these medications?

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