› Forums › General Melanoma Community › Starting on Zelboraf after failing Opdivo
- This topic has 4 replies, 2 voices, and was last updated 7 years, 1 month ago by
Summer S..
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- December 15, 2018 at 8:14 pm
Hi :))
My mom 71 y/o was diagnosed with Stage IV melanoma in May, since tumors were only spread across the skin and distant lymph nodes doctors decided to start with Immunotherapy alothough she was PL-1 negative. After the first 3 months LDH levels dropped and she was feeling better (more energy, less muscle pain, no itching ..etc) but PET/CT revealed progression, so we continued for another 3 months hoping that it would be psaudoprogression. Unfortunately, it was not. So her doctor recommened Zelboraf
I have been reading about how Zelboraf if not actual cure, it only slows progression or stops it for while, and I am very scared and frustrated now.
I arrange all her doctor appointments, insurance, nutrition, ..etc especially that we live in an African country where melanoma is extremely rare and health care system is complicated anyway. So I really need your advice on what the next step should be? is there an actual solution I should be working on now?
She is starting on her first dose of Zelboraf tonight, and I really hope for the best, but I want to be prepared for the next step.
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- December 15, 2018 at 10:01 pm
Here is a pretty good video explanation of targeted therapy for braf+ patients. Please pay attention to the combination of braf + mek drug being used together, they work better together and less side effects. https://www.youtube.com/watch?v=ZBcRHFGTyGs
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- December 15, 2018 at 10:09 pm
Take a look at the 6min mark about taking braf inhibitor alone. https://www.youtube.com/watch?v=KhV1Zyi6r8E
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- December 15, 2018 at 10:13 pm
One last video link, feature panel looking at case study of braf+ mutation patient. https://www.youtube.com/watch?v=IaIItGM4k80
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