Stage 4 in Sternum

This topic has 5 replies, 2 voices, and was last updated 5 years, 7 months ago by ed williams.

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- September 4, 2018 at 3:46 am
- Quote
Jenine
Participant
Hello All,

Tomorrow marks the final day of treatment for my husbands clinical trial. We have been met with success and challenges over the past two years.

There is still active melanoma present in his sternum. We understand this is a vey difficult area to treat. We are not quite sure what to expect after the final clinical trial treatment of Keytruda and Peg interferon.

Does anybody have ANY suggestions for what our next step shoyd be or how to successfully treat melanoma in the sternum?

Wishing everybody love happiness and good health!

Jenine

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- - September 4, 2018 at 12:47 pm
  - Quote
  ed williams
  Participant
  Hi Jenine, I will assume that you have had Pet-ct which is why you are saying that the met in sternum is still active. How would you describe his response during the trial, is he considered partial responder, stable? What is his Oncology team offering you as far as a plan going forward?
  - September 5, 2018 at 4:12 pm
    
    Quote
    Jenine
    Participant
    
    Hi Ed,
    
    I hope you are well. My husbands sternum tumor started at 4.1 cm x 3.5 cm and is now 2.4 cm x 2.2 cm. We are so super grateful to have had his tumor shrink, but are concerned now that his 2 year clinical trial is over. I understand a tumor near the sternum is very stubborn to treat. We are scheduled to meet with Dr. Kirkwood and team in October to discuss the what’s next. Any help you can offer would be appreciated. Take good care of yourself and thanks again for all the good advise you share.
    
    Best,
    
    Jenine
  - September 5, 2018 at 9:30 pm
    
    Quote
    ed williams
    Participant
    
    Hi Jenine, every big hospital has many different trials going on and each hospital has different oncologist that who might have interests in one area or another. That being said, an example would be Dr. Jason Luke in Chicago (see link below for clinical trial list) has his fingers in a few different things for example adding radiation to immunotherapy treatment to try and get an effect of killing some tumor cell which breaks off small pieces of antigens that can be presented to the immune system so that the immune system can then attack the cancer. Other interesting areas of research at present is adding checkpoint inhibitors to t-vec( injectable) if the tumor is available. Lag-3 + Nivo trials are on going as is NKTR-214 + Nivo as well as TLR-9 trials. TIL's is being offered as part of a trial called LN-122 and is available at many centers. Here are two links for your consideration, you might want to go and take a look at Bubbles blog to get some of her data. Best Wishes!!!Ed http://clinicaltrials.uccrc.org/Display/CTListing?SearchString=Melanoma%20%28skin%29&SearchBy=1  https://www.onclive.com/web-exclusives/fda-grants-ln144-fast-track-status-for-melanoma
  - September 5, 2018 at 9:33 pm
    
    Quote
    ed williams
    Participant
    
    Here are two more links for you, https://www.onclive.com/publications/oncology-live/2017/vol-18-no-5/ox40-agonists-forge-a-path-in-combination-immunotherapy?p=2  https://clinicaltrials.gov/ct2/show/NCT03431948
  - September 5, 2018 at 9:35 pm
    
    Quote
    ed williams
    Participant
    
    https://www.onclive.com/publications/oncology-live/2017/vol-18-no-5/ox40-agonists-forge-a-path-in-combination-immunotherapy

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