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Question about Zelboraf?
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Question about Zelboraf?

› Forums › General Melanoma Community › Question about Zelboraf?

  • Post
    • October 29, 2012 at 9:41 pm
    rrrule32
    Participant

      When the Melanoma tumors create a resistance to Zelboraf, do they become more aggressive than they were before taking Zelboraf?  Do the tumors grow faster once the Zelboraf stops working?

      Thank you for your input,

      Travis

      When the Melanoma tumors create a resistance to Zelboraf, do they become more aggressive than they were before taking Zelboraf?  Do the tumors grow faster once the Zelboraf stops working?

      Thank you for your input,

      Travis

    Viewing 8 reply threads
    • Replies
        • October 30, 2012 at 12:34 am
        MichaelFL
        Participant

          Impossible to answer. Depends on so many things such as the persons genetics, healty etc.

          • October 30, 2012 at 12:34 am
          MichaelFL
          Participant

            Impossible to answer. Depends on so many things such as the persons genetics, healty etc.

            • October 30, 2012 at 12:34 am
            MichaelFL
            Participant

              Impossible to answer. Depends on so many things such as the persons genetics, healty etc.

              • October 30, 2012 at 9:01 pm
              deardad
              Participant

                Hi Travis, I can only speak from my father's experience. Once the Zel stopped the tumors became very aggressive. Now is the time to try everything you can to get things under control. Unforutnately our oncologist in Melbourne believes that after Zel the tumors do become more aggressive. Have you been offered MEK? I'm not sure that it works very well without  BRAF but I'd ask? Stay strong Travis.

                Nahmi 

                • October 30, 2012 at 9:01 pm
                deardad
                Participant

                  Hi Travis, I can only speak from my father's experience. Once the Zel stopped the tumors became very aggressive. Now is the time to try everything you can to get things under control. Unforutnately our oncologist in Melbourne believes that after Zel the tumors do become more aggressive. Have you been offered MEK? I'm not sure that it works very well without  BRAF but I'd ask? Stay strong Travis.

                  Nahmi 

                  • October 30, 2012 at 9:01 pm
                  deardad
                  Participant

                    Hi Travis, I can only speak from my father's experience. Once the Zel stopped the tumors became very aggressive. Now is the time to try everything you can to get things under control. Unforutnately our oncologist in Melbourne believes that after Zel the tumors do become more aggressive. Have you been offered MEK? I'm not sure that it works very well without  BRAF but I'd ask? Stay strong Travis.

                    Nahmi 

                    • October 30, 2012 at 11:16 pm
                    Theresa123
                    Participant

                      I was told by my Dr. at Angeles Clinic not to go on Zelboraf yet because it was a "end stage drug"- after it stopped working the melanomas would explode.  I don't know if this is true, but, it seems like it is the case with a lot of people.   Look into anti-PD 1.  I heard it is a better alternative.

                        • October 31, 2012 at 1:03 pm
                        rrrule32
                        Participant

                          Dammit, I wish our oncologist would have told us that.  Her tumor burden at the time was not very heavy.  Well, hopefully we can get on something quickly then.  Hopefully that something can work.  That's pretty discouraging about Zelboraf.

                          Travis

                          • October 31, 2012 at 1:03 pm
                          rrrule32
                          Participant

                            Dammit, I wish our oncologist would have told us that.  Her tumor burden at the time was not very heavy.  Well, hopefully we can get on something quickly then.  Hopefully that something can work.  That's pretty discouraging about Zelboraf.

                            Travis

                            • October 31, 2012 at 1:03 pm
                            rrrule32
                            Participant

                              Dammit, I wish our oncologist would have told us that.  Her tumor burden at the time was not very heavy.  Well, hopefully we can get on something quickly then.  Hopefully that something can work.  That's pretty discouraging about Zelboraf.

                              Travis

                            • October 30, 2012 at 11:16 pm
                            Theresa123
                            Participant

                              I was told by my Dr. at Angeles Clinic not to go on Zelboraf yet because it was a "end stage drug"- after it stopped working the melanomas would explode.  I don't know if this is true, but, it seems like it is the case with a lot of people.   Look into anti-PD 1.  I heard it is a better alternative.

                              • October 30, 2012 at 11:16 pm
                              Theresa123
                              Participant

                                I was told by my Dr. at Angeles Clinic not to go on Zelboraf yet because it was a "end stage drug"- after it stopped working the melanomas would explode.  I don't know if this is true, but, it seems like it is the case with a lot of people.   Look into anti-PD 1.  I heard it is a better alternative.

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