The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Question about legs

Forums Cutaneous Melanoma Community Question about legs

  • Post
    JoorkaTaa
    Participant
      Hi my father was diagnosed with stage 3 melanoma, and has a problem with one leg can not move it. From 2 months and 1 week drink Tefinlar and Mekinist.
      For about 20 days, he has regained the sensitivity of his thigh and can tighten it up and from the knee below he is numb and there are no movements, has any of you encountered this problem and when can we expect improvement in the leg.?
    Viewing 3 reply threads
    • Replies
        Bubbles
        Participant
          Hi Joorka,
          I am sorry for what you and your father are dealing with. However, in my knowledge of BRAF inhibitors over the years, I have not seen this as a side effect. I suppose if he had surgery on this leg (though you don’t mention where his initial lesion was or if lymph nodes were harvested) edema can sometimes cause problems with mobility and function of the limb with which it is associated. Bottom line, this sounds like something that needs to be discussed with his oncologist as soon as possible.

          I wish you both well. Celeste

          JoorkaTaa
          Participant
            Hello before he started taking the drugs there was swelling of the lymphatic but since he drank them, they’ve been fine, and his legs look really good. When sitting on the bed and the legs are down on the ground begin to swell below at the steps. There’s been an improvement on both legs for a month now. Whether or not the problem could be from a pressed buttock nerve because it has a tumor in the pancreas. He’s currently looking at a catheter and diapers because he can’t feel when he needs to go to the toilet. In Bulgaria, doctors do not give high hopes, but the pills he drinks should destroy these tumors and stabilize the situation, right?
            Bubbles
            Participant
              If possible, I think it would be a good idea for your father to have scans to evaluate what is going on generally and perhaps specifically in his spine or abdomen. Targeted therapy (like the pills your dad is taking) works incredibly well for BRAF positive melanoma patients. However, we know that for some, the response is limited in durability. Meaning, the positive response may last for only a limited time. The average is about 9 months though there are those for whom the drugs work for years. Still, finding out what is going on with your father’s tumors is imperative. Immunotherapy, specifically the ipi/nivo (yervoy/opdivo) combination can be helpful. Not sure if your father has had this treatment or not. If not, I would certainly advocate that he be switched to it.

              Yours, celeste

              gopher38
              Participant
                I had leg problems and lasting neuropathy in feet/hand after ipi/nivo, which I think isn’t common, but also not extremely rare, just judging by what I see in the forums. I don’t think it’s listed as a side effect on bms web site, but I’ve heard a number of people mention it. I’m on taf/mek now, and it hasn’t gotten worse (nor better). When I had the leg pain, rather than an ipi side effect (which, like I said, isn’t super common), my onc was worried about spread to spinal fluid or solid tumor in spine. Luckily, spinal tap and full spine MRI came back negative. This thing is a lot of fun, ain’t it?
                Hope your faith continues to improve and it’s got nothing to do with mel or treatments.
            Viewing 3 reply threads
            • You must be logged in to reply to this topic.
            About the MRF Patient Forum

            The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

            The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

            Popular Topics