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Please Explain This Portion Of Pathology

Forums General Melanoma Community Please Explain This Portion Of Pathology

  • Post
    djpayn
    Participant

    Can Anyone Explain This To Me Please.

     

    1. Histolic Sections Show A Deep Scallop Biopsy.  There Is An Isolated Neoplasm Composed Of Atypical Melanocytes In Sheets, Nests, Trabeculae And Single Cells Within The Dermis. There Is Also An Intraepidermal Component Of Irregular Nests And Single Cells With Pagetoid Spread. The Cark's Level is V, The Breslow Thickness Is Greater Than 4.0 MM (Four Point Zero Millimeters). The Tumor Is Transected At The Base. Regression Is Absent. There Are 60 (Sixty) Mitosis Per Square Millimeter.

     

     

    Can Anyone Explain This To Me Please.

     

    1. Histolic Sections Show A Deep Scallop Biopsy.  There Is An Isolated Neoplasm Composed Of Atypical Melanocytes In Sheets, Nests, Trabeculae And Single Cells Within The Dermis. There Is Also An Intraepidermal Component Of Irregular Nests And Single Cells With Pagetoid Spread. The Cark's Level is V, The Breslow Thickness Is Greater Than 4.0 MM (Four Point Zero Millimeters). The Tumor Is Transected At The Base. Regression Is Absent. There Are 60 (Sixty) Mitosis Per Square Millimeter.

     

     

    I Am Uncertain What This Means And Am Concerned With The Mitosis Rate. Please Explain Mitosis And If This Rate (60) Is Common Or Bad.

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      Cynthia C
      Participant

      I can't answer your mitosis question. My interpretation of the above report is that person it refers to needs to be at the best possible Melanoma center immediately.

      Sending positive thoughts your way, Cynthia

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      Cynthia C
      Participant

      I can't answer your mitosis question. My interpretation of the above report is that person it refers to needs to be at the best possible Melanoma center immediately.

      Sending positive thoughts your way, Cynthia

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      Janner
      Participant

      When you post a pathology report, it is always best if you post the entire report including diagnosis.  However, this appears to be a deep and quickly dividing melanoma.  The lesion is at least 4mm deep and has entered the subcutaneous fat layer (Clark's Level V).  The biopsy cut through the bottom of the lesion so you won't ever really know the actual depth – but once a lesion is over 4mm, staging doesn't change anyway.  A mitosis of 60 is considered high.  Ideally, you'd like to see 0.  Mitosis means the number of cells seen actively dividing in a specific sized area.  This looks like a higher risk lesion.  A SNB and possibly scans would be the next steps here if not already done.  I agree with the other poster that it's probably a good thing to be seen by a melanoma specialist on this one. 

      Best wishes,

      Janner

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      Janner
      Participant

      When you post a pathology report, it is always best if you post the entire report including diagnosis.  However, this appears to be a deep and quickly dividing melanoma.  The lesion is at least 4mm deep and has entered the subcutaneous fat layer (Clark's Level V).  The biopsy cut through the bottom of the lesion so you won't ever really know the actual depth – but once a lesion is over 4mm, staging doesn't change anyway.  A mitosis of 60 is considered high.  Ideally, you'd like to see 0.  Mitosis means the number of cells seen actively dividing in a specific sized area.  This looks like a higher risk lesion.  A SNB and possibly scans would be the next steps here if not already done.  I agree with the other poster that it's probably a good thing to be seen by a melanoma specialist on this one. 

      Best wishes,

      Janner

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