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Painful red lumps on zelboraf?
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Painful red lumps on zelboraf?

› Forums › General Melanoma Community › Painful red lumps on zelboraf?

  • Post
    • April 13, 2014 at 5:44 pm
    Ased
    Participant

      Hello to all. My wife has been diagnosed with melanoma stage 4. Mass in esophagus and small spots in both lungs. She started on zelboraf last Monday. We are in Canada, so ipi is only available as second line treatment.  First few days she felt great, but yesterday she started to develop red painfull lumps on her legs and a few on her arms. I read the side effects and it is listed as a possible side effect, but it did say to contact physician immediately if it was present. It's Sunday so we can't call the oncologist until tomorrow about them. She is having a really hard time today as they are extremely painfull.

      Has anyone else on zelboraf experienced this, and if so did the symptoms last or go away?

      Thanks,

       

      Ased

       

    Viewing 11 reply threads
    • Replies
        • April 13, 2014 at 10:47 pm
        paul
        Participant

          Hello Ased.

          Do you mean a rash? Lumps sounds like it might be a different sort of reaction. 

          I had a serious Zelboraf rash. Was put on prednisone, took a week off, and then resumed at a reduced dose, and things did get better fairly quickly. It sounds from reading accounts that skin reactions are common and often dramatic: several people on this list have described going to the Emergency room for steroid IV. I think the instructions are to withold dose until talking to a physician if there is a serious reaction.

          All the best to you and your wife,

          Paul

           

          • April 13, 2014 at 10:47 pm
          paul
          Participant

            Hello Ased.

            Do you mean a rash? Lumps sounds like it might be a different sort of reaction. 

            I had a serious Zelboraf rash. Was put on prednisone, took a week off, and then resumed at a reduced dose, and things did get better fairly quickly. It sounds from reading accounts that skin reactions are common and often dramatic: several people on this list have described going to the Emergency room for steroid IV. I think the instructions are to withold dose until talking to a physician if there is a serious reaction.

            All the best to you and your wife,

            Paul

             

            • April 13, 2014 at 10:47 pm
            paul
            Participant

              Hello Ased.

              Do you mean a rash? Lumps sounds like it might be a different sort of reaction. 

              I had a serious Zelboraf rash. Was put on prednisone, took a week off, and then resumed at a reduced dose, and things did get better fairly quickly. It sounds from reading accounts that skin reactions are common and often dramatic: several people on this list have described going to the Emergency room for steroid IV. I think the instructions are to withold dose until talking to a physician if there is a serious reaction.

              All the best to you and your wife,

              Paul

               

              • April 14, 2014 at 2:27 am
              bj63
              Participant

                I had a painful, itchy rash when I first started Zelboraf, mainly on my lower legs and in patches on my trunk.  I treated them with OTC Cortizone-10 ointment, wore long cotton socks, and kept on going with no dose reduction.  The rash lasted for about 4 – 5 weeks and eventually subsided.

                Talk to your doctor.

                  • April 14, 2014 at 3:26 am
                  Ased
                  Participant

                    Thank you both for your input. This is more of a lump, painfull and swollen, not really a rash. We are going to call the oncologist tomorrow morning. Good to see there are options for treating some of the side effects. Thanks again for taking the time to reply to my post, it is appreciated!

                     

                    Ased

                    • April 15, 2014 at 1:18 pm
                    mary in Rhode Island
                    Participant

                      Hi Ased,  I had a very similar situation on the bottom of my feet when I started using Zelboraf.  It was called "nodosum" and made walking very painful.  Fortunately, it resolved itself.  As a matter of fact, I was off Zelboraf for 2 weeks and the "nodosum" returned when I started the Zelboraf again.  It is resolving as we speak.  I hope your situation is the same.  Best wishes, Mary

                      • April 15, 2014 at 1:18 pm
                      mary in Rhode Island
                      Participant

                        Hi Ased,  I had a very similar situation on the bottom of my feet when I started using Zelboraf.  It was called "nodosum" and made walking very painful.  Fortunately, it resolved itself.  As a matter of fact, I was off Zelboraf for 2 weeks and the "nodosum" returned when I started the Zelboraf again.  It is resolving as we speak.  I hope your situation is the same.  Best wishes, Mary

                        • April 15, 2014 at 1:18 pm
                        mary in Rhode Island
                        Participant

                          Hi Ased,  I had a very similar situation on the bottom of my feet when I started using Zelboraf.  It was called "nodosum" and made walking very painful.  Fortunately, it resolved itself.  As a matter of fact, I was off Zelboraf for 2 weeks and the "nodosum" returned when I started the Zelboraf again.  It is resolving as we speak.  I hope your situation is the same.  Best wishes, Mary

                          • April 14, 2014 at 3:26 am
                          Ased
                          Participant

                            Thank you both for your input. This is more of a lump, painfull and swollen, not really a rash. We are going to call the oncologist tomorrow morning. Good to see there are options for treating some of the side effects. Thanks again for taking the time to reply to my post, it is appreciated!

                             

                            Ased

                            • April 14, 2014 at 3:26 am
                            Ased
                            Participant

                              Thank you both for your input. This is more of a lump, painfull and swollen, not really a rash. We are going to call the oncologist tomorrow morning. Good to see there are options for treating some of the side effects. Thanks again for taking the time to reply to my post, it is appreciated!

                               

                              Ased

                            • April 14, 2014 at 2:27 am
                            bj63
                            Participant

                              I had a painful, itchy rash when I first started Zelboraf, mainly on my lower legs and in patches on my trunk.  I treated them with OTC Cortizone-10 ointment, wore long cotton socks, and kept on going with no dose reduction.  The rash lasted for about 4 – 5 weeks and eventually subsided.

                              Talk to your doctor.

                              • April 14, 2014 at 2:27 am
                              bj63
                              Participant

                                I had a painful, itchy rash when I first started Zelboraf, mainly on my lower legs and in patches on my trunk.  I treated them with OTC Cortizone-10 ointment, wore long cotton socks, and kept on going with no dose reduction.  The rash lasted for about 4 – 5 weeks and eventually subsided.

                                Talk to your doctor.

                                • April 15, 2014 at 4:31 pm
                                GAngel
                                Participant

                                  Hi there. I'm sorry that your wife is experiencing this painful side effect from Zel, my husband  also suffered the same reaction. His dosage was reduced as a result and he also did intermittent dosing  of every other week. He was a total responder and switched to the combo while still responding to Zel to see if side effects were better with combo. He's been on combo for almost 9 months and remains NED!  I would ask about switching to combo as an option for your wife.

                                  Best of luck to you both! I'll be praying for you and your wife. Never give up hope!

                                  Gina

                                  • April 15, 2014 at 4:31 pm
                                  GAngel
                                  Participant

                                    Hi there. I'm sorry that your wife is experiencing this painful side effect from Zel, my husband  also suffered the same reaction. His dosage was reduced as a result and he also did intermittent dosing  of every other week. He was a total responder and switched to the combo while still responding to Zel to see if side effects were better with combo. He's been on combo for almost 9 months and remains NED!  I would ask about switching to combo as an option for your wife.

                                    Best of luck to you both! I'll be praying for you and your wife. Never give up hope!

                                    Gina

                                      • April 15, 2014 at 4:39 pm
                                      GAngel
                                      Participant

                                        P.s. The side effects are much more manageable on the combo for most patients!  However, if the combo isn't  an option for some reason then please know that Zel side effects do subside for many patients or can become manageable!!

                                        • April 15, 2014 at 4:39 pm
                                        GAngel
                                        Participant

                                          P.s. The side effects are much more manageable on the combo for most patients!  However, if the combo isn't  an option for some reason then please know that Zel side effects do subside for many patients or can become manageable!!

                                          • April 15, 2014 at 4:39 pm
                                          GAngel
                                          Participant

                                            P.s. The side effects are much more manageable on the combo for most patients!  However, if the combo isn't  an option for some reason then please know that Zel side effects do subside for many patients or can become manageable!!

                                          • April 15, 2014 at 4:31 pm
                                          GAngel
                                          Participant

                                            Hi there. I'm sorry that your wife is experiencing this painful side effect from Zel, my husband  also suffered the same reaction. His dosage was reduced as a result and he also did intermittent dosing  of every other week. He was a total responder and switched to the combo while still responding to Zel to see if side effects were better with combo. He's been on combo for almost 9 months and remains NED!  I would ask about switching to combo as an option for your wife.

                                            Best of luck to you both! I'll be praying for you and your wife. Never give up hope!

                                            Gina

                                            • April 17, 2014 at 12:51 am
                                            Tina D
                                            Participant

                                              Yes, I had these painful red bumps while on the zelboraf. They hurt lots! They would appear in a few places at once, then after several days those would go away. After some days more would appear elsewhere. After I was on the med for a few months the frequency did seem to lessen. I noticed they seemed to appear when my other symptoms were at their peak.

                                              Tina

                                              • April 17, 2014 at 12:51 am
                                              Tina D
                                              Participant

                                                Yes, I had these painful red bumps while on the zelboraf. They hurt lots! They would appear in a few places at once, then after several days those would go away. After some days more would appear elsewhere. After I was on the med for a few months the frequency did seem to lessen. I noticed they seemed to appear when my other symptoms were at their peak.

                                                Tina

                                                • April 17, 2014 at 12:51 am
                                                Tina D
                                                Participant

                                                  Yes, I had these painful red bumps while on the zelboraf. They hurt lots! They would appear in a few places at once, then after several days those would go away. After some days more would appear elsewhere. After I was on the med for a few months the frequency did seem to lessen. I noticed they seemed to appear when my other symptoms were at their peak.

                                                  Tina

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