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P13K or Mek inhibitor, Anyone??
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P13K or Mek inhibitor, Anyone??

› Forums › General Melanoma Community › P13K or Mek inhibitor, Anyone??

  • Post
    • August 22, 2010 at 1:58 pm
    emilypen
    Participant

      Hi All,

      My husband is about to start a combo trial of BKM120 ( a P13K inhibitor) and GSK1120212 ( a MEK inhibitor). Just wondering if anybody on the board has taken either of these drugs separately? and if so what were the side effects and results?

      Hubby is stage IV with bone mets and 1 soft tissue tumour, and about to start radiation for the bone mets pain this week.

      thanks,

      Emily

      Hi All,

      My husband is about to start a combo trial of BKM120 ( a P13K inhibitor) and GSK1120212 ( a MEK inhibitor). Just wondering if anybody on the board has taken either of these drugs separately? and if so what were the side effects and results?

      Hubby is stage IV with bone mets and 1 soft tissue tumour, and about to start radiation for the bone mets pain this week.

      thanks,

      Emily

    Viewing 1 reply thread
    • Replies
        • August 22, 2010 at 11:15 pm
        Lori CO
        Participant

          Hi Emily,

          I've been on the GSK MEK trial since March with good results, 3 tumors have completely disappeared. The side effects were terrible at first until the dosage was lowered from 2.5 mg to 2.0 mg. Now they are pretty minimal. The worst is the rash which I keep under control with cream and antibiotics. It has gotten better over time. I also watch what I eat to prevent stomach aches.

          Where is the BKM120 trial? I am being treated at the University of Colorado Cancer Center. 

          Good luck to both of you and I hope you will post your husband's progress on the trial.

          Lori

          Stage IV

          Grand Junction, CO

           

            • August 23, 2010 at 12:53 am
            Terra
            Participant

              We are actually getting Derek's tumour tested for this trial here in Toronto for the NRAS mutation.  Where are you enrolled and how is it going

              • August 23, 2010 at 12:53 am
              Terra
              Participant

                We are actually getting Derek's tumour tested for this trial here in Toronto for the NRAS mutation.  Where are you enrolled and how is it going

                • August 23, 2010 at 7:05 pm
                emilypen
                Participant

                  That's great news… thanks for the info.

                  The combo trial is at Princess Margaret Hospital in Toronto. http://clinicaltrials.gov/ct2/show/NCT01155453

                   

                  Emily

                  • August 23, 2010 at 7:05 pm
                  emilypen
                  Participant

                    That's great news… thanks for the info.

                    The combo trial is at Princess Margaret Hospital in Toronto. http://clinicaltrials.gov/ct2/show/NCT01155453

                     

                    Emily

                  • August 22, 2010 at 11:15 pm
                  Lori CO
                  Participant

                    Hi Emily,

                    I've been on the GSK MEK trial since March with good results, 3 tumors have completely disappeared. The side effects were terrible at first until the dosage was lowered from 2.5 mg to 2.0 mg. Now they are pretty minimal. The worst is the rash which I keep under control with cream and antibiotics. It has gotten better over time. I also watch what I eat to prevent stomach aches.

                    Where is the BKM120 trial? I am being treated at the University of Colorado Cancer Center. 

                    Good luck to both of you and I hope you will post your husband's progress on the trial.

                    Lori

                    Stage IV

                    Grand Junction, CO

                     

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