› Forums › General Melanoma Community › opdivo side effects?
- This topic has 36 replies, 4 voices, and was last updated 8 years, 3 months ago by blessd4x.
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- December 16, 2015 at 3:39 am
Tried to put this in one post but was blocked. Will try in parts.
Link to anti-PD1 side effects generally: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumab.html
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- December 16, 2015 at 3:39 am
Tried to put this in one post but was blocked. Will try in parts.
Link to anti-PD1 side effects generally: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumab.html
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- December 16, 2015 at 3:39 am
Tried to put this in one post but was blocked. Will try in parts.
Link to anti-PD1 side effects generally: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumab.html
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- December 16, 2015 at 3:41 am
Long boring post of my side effects and when they appeared during my 2 1/2 tyear nivo/opdivo trial: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumabmy-story.html
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- December 16, 2015 at 3:41 am
Long boring post of my side effects and when they appeared during my 2 1/2 tyear nivo/opdivo trial: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumabmy-story.html
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- December 16, 2015 at 3:41 am
Long boring post of my side effects and when they appeared during my 2 1/2 tyear nivo/opdivo trial: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumabmy-story.html
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- December 16, 2015 at 3:44 am
And finally…link to a recent post and excellent webinar by 2 melanoma experts regarding side effects and how to treat them: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/side-effects-and-how-to-manage-them-in.html
I wish you and your husband my best. Celeste
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- December 16, 2015 at 3:44 am
And finally…link to a recent post and excellent webinar by 2 melanoma experts regarding side effects and how to treat them: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/side-effects-and-how-to-manage-them-in.html
I wish you and your husband my best. Celeste
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- December 16, 2015 at 3:44 am
And finally…link to a recent post and excellent webinar by 2 melanoma experts regarding side effects and how to treat them: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/side-effects-and-how-to-manage-them-in.html
I wish you and your husband my best. Celeste
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- December 16, 2015 at 8:50 am
Watch out for heart issues. There is at least one documented case of deadly heart failure with pembrolizumab which is very similar to nivolumab (opdivo):
http://www.ncbi.nlm.nih.gov/pubmed/25901283
My father had a dangerously low heart beat rate (38) after his first dose of nivolumab. He suffers from atrial fibrillation for at least 20 years now so maybe people who already have heart issues should be careful while on immunotherapy. He also developed pneumonitis and fatigue for some weeks after his infusion. He didn't get a second dose.
Best of luck to you and your husband.
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- December 16, 2015 at 8:50 am
Watch out for heart issues. There is at least one documented case of deadly heart failure with pembrolizumab which is very similar to nivolumab (opdivo):
http://www.ncbi.nlm.nih.gov/pubmed/25901283
My father had a dangerously low heart beat rate (38) after his first dose of nivolumab. He suffers from atrial fibrillation for at least 20 years now so maybe people who already have heart issues should be careful while on immunotherapy. He also developed pneumonitis and fatigue for some weeks after his infusion. He didn't get a second dose.
Best of luck to you and your husband.
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- December 16, 2015 at 8:50 am
Watch out for heart issues. There is at least one documented case of deadly heart failure with pembrolizumab which is very similar to nivolumab (opdivo):
http://www.ncbi.nlm.nih.gov/pubmed/25901283
My father had a dangerously low heart beat rate (38) after his first dose of nivolumab. He suffers from atrial fibrillation for at least 20 years now so maybe people who already have heart issues should be careful while on immunotherapy. He also developed pneumonitis and fatigue for some weeks after his infusion. He didn't get a second dose.
Best of luck to you and your husband.
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- December 17, 2015 at 2:35 pm
Thank you all for the feedback! My husband is having severe pains in his pelvic area, "hot flashes" if you will, constipation, fatigue and now having some pretty serious memory issues. I know theres a laundry list of side effects and not everyone gets them all. Of course, Im concerned about them along with every cough and sneeze. Its a roller coaster as you all know.
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- December 17, 2015 at 2:35 pm
Thank you all for the feedback! My husband is having severe pains in his pelvic area, "hot flashes" if you will, constipation, fatigue and now having some pretty serious memory issues. I know theres a laundry list of side effects and not everyone gets them all. Of course, Im concerned about them along with every cough and sneeze. Its a roller coaster as you all know.
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- December 17, 2015 at 3:43 pm
Uh oh, "serious memory issues" could also be a symptom of brain mets or a stroke (maybe caused by bleeding brain mets)! Please let this be monitored asap.
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- December 17, 2015 at 3:43 pm
Uh oh, "serious memory issues" could also be a symptom of brain mets or a stroke (maybe caused by bleeding brain mets)! Please let this be monitored asap.
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- December 17, 2015 at 4:33 pm
thank you for that! He even got into MY car the other day to go somewhere.. He's never driven my car..his last MRI in september showed a very small spot in the brain that could not be determined what it is because it is so small. At that point they were not concerned. He's supposed to get another PET scan in January. The memory issues started a couple weeks ago and are getting worse.
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- December 17, 2015 at 4:33 pm
thank you for that! He even got into MY car the other day to go somewhere.. He's never driven my car..his last MRI in september showed a very small spot in the brain that could not be determined what it is because it is so small. At that point they were not concerned. He's supposed to get another PET scan in January. The memory issues started a couple weeks ago and are getting worse.
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- December 17, 2015 at 4:33 pm
thank you for that! He even got into MY car the other day to go somewhere.. He's never driven my car..his last MRI in september showed a very small spot in the brain that could not be determined what it is because it is so small. At that point they were not concerned. He's supposed to get another PET scan in January. The memory issues started a couple weeks ago and are getting worse.
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- December 17, 2015 at 7:22 pm
There is nothing that I have come across in my research that would suggest that the symptoms you are talking about as far as memory would be associated with Opdivo. They do list under 5 to 20% chance of happening "confusion" caused by low blood phosphate level. However my own experience tells me that brain mets pop up fast and the sooner treated the better the outcome. I would push for an appointment with your oncologist to discuss the side effects he is having. With melanoma and Pd-1 drugs communication with your oncologist is very important. Wishing you the best!!!! Ed
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- December 17, 2015 at 7:22 pm
There is nothing that I have come across in my research that would suggest that the symptoms you are talking about as far as memory would be associated with Opdivo. They do list under 5 to 20% chance of happening "confusion" caused by low blood phosphate level. However my own experience tells me that brain mets pop up fast and the sooner treated the better the outcome. I would push for an appointment with your oncologist to discuss the side effects he is having. With melanoma and Pd-1 drugs communication with your oncologist is very important. Wishing you the best!!!! Ed
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- December 17, 2015 at 7:22 pm
There is nothing that I have come across in my research that would suggest that the symptoms you are talking about as far as memory would be associated with Opdivo. They do list under 5 to 20% chance of happening "confusion" caused by low blood phosphate level. However my own experience tells me that brain mets pop up fast and the sooner treated the better the outcome. I would push for an appointment with your oncologist to discuss the side effects he is having. With melanoma and Pd-1 drugs communication with your oncologist is very important. Wishing you the best!!!! Ed
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- December 18, 2015 at 11:21 am
Please call your oncologist NOW.
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- December 18, 2015 at 11:21 am
Please call your oncologist NOW.
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- December 18, 2015 at 2:16 pm
Maybe ask her how about giving him Dexamthasone? This is a serious situation – if brain mets are bleeding damage could be permanent if he isn't treated as soon as possible. Please try to convince him.
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- December 18, 2015 at 2:16 pm
Maybe ask her how about giving him Dexamthasone? This is a serious situation – if brain mets are bleeding damage could be permanent if he isn't treated as soon as possible. Please try to convince him.
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- December 18, 2015 at 2:16 pm
Maybe ask her how about giving him Dexamthasone? This is a serious situation – if brain mets are bleeding damage could be permanent if he isn't treated as soon as possible. Please try to convince him.
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- December 18, 2015 at 11:21 am
Please call your oncologist NOW.
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- December 17, 2015 at 3:43 pm
Uh oh, "serious memory issues" could also be a symptom of brain mets or a stroke (maybe caused by bleeding brain mets)! Please let this be monitored asap.
-
- December 17, 2015 at 2:35 pm
Thank you all for the feedback! My husband is having severe pains in his pelvic area, "hot flashes" if you will, constipation, fatigue and now having some pretty serious memory issues. I know theres a laundry list of side effects and not everyone gets them all. Of course, Im concerned about them along with every cough and sneeze. Its a roller coaster as you all know.
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