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New trial of P13Kinase and MTOR inhibitor. Anyone familiar with this?
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New trial of P13Kinase and MTOR inhibitor. Anyone familiar with this?

› Forums › General Melanoma Community › New trial of P13Kinase and MTOR inhibitor. Anyone familiar with this?

  • Post
    • September 22, 2011 at 4:29 pm
    rbruce
    Participant

      My UCSF Onc just provided the following link to a trial they have going.  I am not familiar with this at all.  I'm waiting for an Anti-PD1 trial they say is going to start in November and he suggests doing this one in the meantime. 

      Any help would be appreciated.

      http://clinicaltrials.gov/ct2/show/NCT00972686?term=gsk+2126458&rank=2

      My UCSF Onc just provided the following link to a trial they have going.  I am not familiar with this at all.  I'm waiting for an Anti-PD1 trial they say is going to start in November and he suggests doing this one in the meantime. 

      Any help would be appreciated.

      http://clinicaltrials.gov/ct2/show/NCT00972686?term=gsk+2126458&rank=2

      The drug is GSK 2126458 and it is a dual PI3Kinase and MTOR inhibitor given by mouth.  1 pill a day on 28 day cycle.

      Thanks!

      Robert

    Viewing 1 reply thread
    • Replies
        • September 23, 2011 at 12:44 am
        killmel
        Participant

          Robert,

          I would be a little scared to do  "first-time-in-human" dose escalation study of P3K112826

          but that is just me.

          I noticed at UCSF there is a GSK braf/mek combo trial,what about that. These two drugs have proven effective. Howeve, no data on results as yet.

          Just a thought.

          Good Luck & keep us posted.

          Mary

            • September 23, 2011 at 2:53 am
            rbruce
            Participant

              I am not BRAF positive, I am NRAS.  I will have new scans next week and if things haven't changed much I will probably wait for the antiPD-1 trial in November.

              Robert

              • September 24, 2011 at 2:00 am
              jim Breitfeller
              Participant

                Bob, If it was me, I would try the P13K and The MTOR combo.

                It is blocking the VEGF pathway whick may cut off the vascular pathway for the tumors blocking them from growing.

                Best regards,

                Jimmy B

                • September 24, 2011 at 7:36 pm
                rbruce
                Participant

                  Thanks Jimmy B for the great information, I really appreciate it.  Gives me something to discuss with my Oncologist.    Robert

                  • September 24, 2011 at 7:36 pm
                  rbruce
                  Participant

                    Thanks Jimmy B for the great information, I really appreciate it.  Gives me something to discuss with my Oncologist.    Robert

                    • September 24, 2011 at 2:00 am
                    jim Breitfeller
                    Participant

                      Bob, If it was me, I would try the P13K and The MTOR combo.

                      It is blocking the VEGF pathway whick may cut off the vascular pathway for the tumors blocking them from growing.

                      Best regards,

                      Jimmy B

                      • September 24, 2011 at 5:43 am
                      JerryfromFauq
                      Participant
                        • September 24, 2011 at 7:39 pm
                        rbruce
                        Participant

                          Jerry , thanks for the link to the article, it is very informative.  So much is changing daily that I sometimes feel like members of this forum are more up to date than a lot of the Oncs we see.  I'm glad that UCSF is only a couple of hours away and have a few Melanoma specialists.  I meet with them on Oct 5th to determine my next moves.  Thank you again.  Robert

                          • September 25, 2011 at 1:55 am
                          JerryfromFauq
                          Participant

                            Robert, I started out emailing posted items from the MPIP to my Oncologists.  They are very knowledge men, but from the time they spend with their patients, I figured that even a Melanoma specialist could not keep up with all the happenings (no way a general Oncologist can even think of following all of everything for all cancers.).  I have actually received thank you's from my Oncs for sending them items!   They often even forward what I send them to other members of the University staff! There are so many of us looking at things.  No one person can review every thing.  (I do try to keep from overloading them with all that we come up with.)

                            • September 25, 2011 at 1:55 am
                            JerryfromFauq
                            Participant

                              Robert, I started out emailing posted items from the MPIP to my Oncologists.  They are very knowledge men, but from the time they spend with their patients, I figured that even a Melanoma specialist could not keep up with all the happenings (no way a general Oncologist can even think of following all of everything for all cancers.).  I have actually received thank you's from my Oncs for sending them items!   They often even forward what I send them to other members of the University staff! There are so many of us looking at things.  No one person can review every thing.  (I do try to keep from overloading them with all that we come up with.)

                              • September 24, 2011 at 7:39 pm
                              rbruce
                              Participant

                                Jerry , thanks for the link to the article, it is very informative.  So much is changing daily that I sometimes feel like members of this forum are more up to date than a lot of the Oncs we see.  I'm glad that UCSF is only a couple of hours away and have a few Melanoma specialists.  I meet with them on Oct 5th to determine my next moves.  Thank you again.  Robert

                                • September 24, 2011 at 5:43 am
                                JerryfromFauq
                                Participant
                                  • September 23, 2011 at 2:53 am
                                  rbruce
                                  Participant

                                    I am not BRAF positive, I am NRAS.  I will have new scans next week and if things haven't changed much I will probably wait for the antiPD-1 trial in November.

                                    Robert

                                  • September 23, 2011 at 12:44 am
                                  killmel
                                  Participant

                                    Robert,

                                    I would be a little scared to do  "first-time-in-human" dose escalation study of P3K112826

                                    but that is just me.

                                    I noticed at UCSF there is a GSK braf/mek combo trial,what about that. These two drugs have proven effective. Howeve, no data on results as yet.

                                    Just a thought.

                                    Good Luck & keep us posted.

                                    Mary

                                Viewing 1 reply thread
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