New Phase 3 trial in Melanoma that might be of interest to some!!!!

This topic has 6 replies, 3 voices, and was last updated 6 years, 7 months ago by ed williams.

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- June 9, 2019 at 4:33 pm
- Quote
ed williams
Participant

Any one that has been following the NKTR-214 + Nivo (opdivo) early phase trials will be familiar with NKTR-214 a pegylated version of IL-2 which makes it less toxic from what the early data is showing. The big pharma companies love to change names of things along the way so now NKTR-214 has a new name (bempegaldesleukin), I guess pegylated is in there plus leukin for Interleukin I guess!!! Here are two links talking about the new trial, and if you want to find out more data, then search under Pivot trial ( that is what the early trial was called). Have a nice Sunday folks!!! https://www.cancernetwork.com/asco-melanoma/investigators-are-assessing-experimental-interleukin-2-drug-patients-metastatic-melanoma?cid=tw&fbclid=IwAR0K6i6SZUjWKXukdVUbafaKdVQqsNNq384Dh4yAPtsil6hwvTfuTzW1UhE https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.TPS9601

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- - June 9, 2019 at 4:35 pm
  - Quote
  ed williams
  Participant
  
  For those that like to listen rather than read their information, here is a link to Dr. Diab of MD Anderson talking about NKTR-214. https://www.onclive.com/inside-oncology/solid-tumor-pivot02/the-pivot02-trial-nktr214-with-nivolumab
  - June 9, 2019 at 10:07 pm
    
    Quote
    Mark_DC
    Participant
    
    Thanks for posting Ed – its good to know all the options and also I want to hear of new treatmenrs!
- - June 10, 2019 at 12:33 am
  - Quote
  MelanomaMike
  Participant
  
  Hay Ed! hows it going man? Thanks for posting this, i may need to start lookin into other treatment options, my current Opdivo regement and now 19 bags into it is not panning out anylonger, (new tumors are popping up) im basicly still on it cuz it is keeping my lung tumors from growing, pros & cons…thanks again for the lead..
  - June 10, 2019 at 3:57 pm
    
    Quote
    ed williams
    Participant
    
    Hi Mike, you might want to take a look at the Iovance Biotherapeutics(TIL’s trial as well) with trials available at “The Angeles Clinic” data from phase 2 heavily pre-treated patients at ASCO 2019 in following link. First link is ASCO post followed by original trial article form 2017. https://abstracts.asco.org/239/AbstView_239_266867.html https://www.onclive.com/web-exclusives/fda-grants-ln144-fast-track-status-for-melanoma
  - June 10, 2019 at 3:58 pm
    
    Quote
    ed williams
    Participant
    
    Here is another article about TIL’s in general, there are a few different methods and locations that offer TIL’s around the world. https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0391-1
  - June 12, 2019 at 5:19 pm
    
    Quote
    ed williams
    Participant
    
    One more for you to look at Mike, is a presentation by Dr. Omid Hamid of the Angeles Clinic in May of this year on new drugs and melanoma treatment advancements. https://www.youtube.com/watch?v=fbSHUEbhTho&feature=youtu.be

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New Phase 3 trial in Melanoma that might be of interest to some!!!!

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