New nivo dosing and hospitalization

Good to know, I'm still on twice weekly, haven't been offered the monthly option yet, inconvenient but way better than hosptialization!

I am glad you are doing well and your doc is keeping close tabs!!!  I've been worried about that jump in dosage.  When this was first being bandied about in the research it had looked at though they were thinking to keep the same dose and just spread out the time frame.  After all, in my study, for instance ~ there were 3 dosage groups: 1mg/kg (my group), 3 mg/kg, and 10 mg/kg.  All of the groups (and these were all Stage IV peeps) did pretty well.  But, on top of that, we were given our respective doses every 2 weeks for 6 months and then were only administered that same dose every 3 months for 2 more years.  So, roughtly…folks have been getting the 3mg/kg dose (240mg) every 2 weeks but now have been bumped up to a roughly 6mg/kg dose with the 480mg dose every 4 week schedule.  It will be "interesting" to see how this plays out.  

Here's the published report on the ratties in my trial for those of you who are interested:  

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/12/cest-moi-results-from-33-raties-in-my.html  

My thoughts on same (at that time): 

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/12/my-nivo-opdivo-trial-first-dose-4-years.html

My trial, as described in the report, ran from 2010 – 2013 give or take.  It morphed into many additional arms….those who did not take the vaccine, those who HAD already taken ipi, and even included an ipi/nivo arm…as time went on.  We've learned a lot since then.  Thanks to ratties like you…we will learn even more.  Will be keeping my fingers crossed for all of you!!!  Hang in there!  And thanks for sharing some super important intel!   celeste

Thank you for posting this.   My wife has been on the 2 week regimen of Nivo for a few months and her melanoma specialist had mentioned possibly moving her to every 4 weeks at the 6 month point.  This was even before the FDA approval of the 4 week protocol.   This will give us another data point to consider.   I have been concerned about the possibility of increased adverse effects with increased dosage, as she has only have very minor side effects on her current regimen.  She's small, only 110 lb, so I think the 240 mg is probably dosing her pretty good presently.

Super interesting….I just had my first Nivo infusion with the new 480 dose, and I felt like I was hit by a truck yesterday.  My head feels like it is in a cloud….my stomach is extra sensitive…I'm EXHAUSTED.  I had been on the every 2-week regimine, and was excited to have the new 4 week rotation, but not after getting the infusion yesterday! 

Hey friends,  I have been on Opdivo for 27 infusions and was changed to the new 4-week regimen last week (for the 28th infusion).  So far, so good.  Noticing a bit more fatigue but totally manageable.  I just have to get up from my desk and walk around a bit more. It is interesting to read the different reactions.  I hope Bristol Meyers Squibb is taking note.  Keep fighting on – no alternative, right?