› Forums › General Melanoma Community › My BRAF/MEK Status Report
- This topic has 24 replies, 8 voices, and was last updated 12 years, 1 month ago by
jag.
- Post
-
- October 28, 2011 at 6:42 am
I'm well into the 6th month of the GSK BRAF/MEK study, taking the highest dosages of the 2 drug combo. I'm happy to report that, as of the scans I had on Monday, all mets have either shrunk to sub-clinical size (i.e. cannot be imaged by MRI or CT) or (in the case of a couple of bone mets) seem stable. The bone mets may actually be non-viable, but the damage they previously caused will probably always show on the scans.
I'm well into the 6th month of the GSK BRAF/MEK study, taking the highest dosages of the 2 drug combo. I'm happy to report that, as of the scans I had on Monday, all mets have either shrunk to sub-clinical size (i.e. cannot be imaged by MRI or CT) or (in the case of a couple of bone mets) seem stable. The bone mets may actually be non-viable, but the damage they previously caused will probably always show on the scans.
Very few side effects to report – most went away after the 1st few weeks. Apparently the BRAF/MEK combo results in fewer patient complaints than the BRAF alone. And according to staff at the Angeles Clinic, so far they have not seen the dreaded acquired resistance to the combo inhibitors (that has been a problem with BRAF alone).
Best wishes,
Harry
- Replies
-
-
- October 28, 2011 at 9:47 am
wow Harry ! I’m a recent returnee to the mpip (prompted by a good friend’s progression to stage IV) so your story is new to me….but wow! That’s really kicking Mel where it hurts! go you πFingers crossed that you have a durable and lasting response. Your profile seems to suggest that your immune system has a good idea of how to keep it in check, so I really hope that this trial sees the back of Mel for another…oh, let’s say 50 years or so ?
π
AlisonC
Stage IIIB
NED since 2001 -
- October 28, 2011 at 9:47 am
wow Harry ! I’m a recent returnee to the mpip (prompted by a good friend’s progression to stage IV) so your story is new to me….but wow! That’s really kicking Mel where it hurts! go you πFingers crossed that you have a durable and lasting response. Your profile seems to suggest that your immune system has a good idea of how to keep it in check, so I really hope that this trial sees the back of Mel for another…oh, let’s say 50 years or so ?
π
AlisonC
Stage IIIB
NED since 2001 -
- October 28, 2011 at 9:47 am
wow Harry ! I’m a recent returnee to the mpip (prompted by a good friend’s progression to stage IV) so your story is new to me….but wow! That’s really kicking Mel where it hurts! go you πFingers crossed that you have a durable and lasting response. Your profile seems to suggest that your immune system has a good idea of how to keep it in check, so I really hope that this trial sees the back of Mel for another…oh, let’s say 50 years or so ?
π
AlisonC
Stage IIIB
NED since 2001 -
- October 28, 2011 at 11:01 am
Harry,
Congrats!!!!
Is there a maintenance protocol on your trial? The trick is to kill every last melanoma cell in your body. A maintenance regime may just be what you might need.
Wishing you all the best
Jimmy B
-
- October 28, 2011 at 11:01 am
Harry,
Congrats!!!!
Is there a maintenance protocol on your trial? The trick is to kill every last melanoma cell in your body. A maintenance regime may just be what you might need.
Wishing you all the best
Jimmy B
-
- October 28, 2011 at 11:01 am
Harry,
Congrats!!!!
Is there a maintenance protocol on your trial? The trick is to kill every last melanoma cell in your body. A maintenance regime may just be what you might need.
Wishing you all the best
Jimmy B
-
- October 28, 2011 at 3:48 pm
Awesome news for you Harry! It's so great to hear about good responses to a new treatment option.
SF Chronicle has an article out this morning about UCSF's participation in this trial, with quotes from GSK's director of oncology research, and from a patient with a response that sounds similar to yours.
It feels like "they're" chipping away a little bit more, unraveling one more piece of the huge puzzle. It's very cool when you are part of that new piece π
-
- October 28, 2011 at 3:48 pm
Awesome news for you Harry! It's so great to hear about good responses to a new treatment option.
SF Chronicle has an article out this morning about UCSF's participation in this trial, with quotes from GSK's director of oncology research, and from a patient with a response that sounds similar to yours.
It feels like "they're" chipping away a little bit more, unraveling one more piece of the huge puzzle. It's very cool when you are part of that new piece π
-
- October 28, 2011 at 3:48 pm
Awesome news for you Harry! It's so great to hear about good responses to a new treatment option.
SF Chronicle has an article out this morning about UCSF's participation in this trial, with quotes from GSK's director of oncology research, and from a patient with a response that sounds similar to yours.
It feels like "they're" chipping away a little bit more, unraveling one more piece of the huge puzzle. It's very cool when you are part of that new piece π
- You must be logged in to reply to this topic.