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Mucosal treatment

Forums Mucosal Melanoma Community Mucosal treatment

  • Post
    RGal
    Participant

      Not to simplify too much but without any know mutations, what current treatment is showing the best numbers for mucosal melanoma?  

    Viewing 2 reply threads
    • Replies
        arthurjedi007
        Participant

          The best for all according to the numbers is ipi pd1 combo. But I don't believe they distinguish out mucosal. There are some severe but manageable side affects.

          Jerry probably knows more about mucosal.

          Artie

            mary1233
            Participant

              I asked my oncologist at Sloan what is more relevant in relation to treatment – the fact that I have mucosal melanoma or the mutation status. He said, without a doubt, the mutation status.

              I had surgery and chemo in 2012 and 2013 because the immunotherapy was not ready for me. So much has changed and Artie is right – the ipi – PD-1 combo results are very impressive.

              I just hope you choose to go to a major research center. They not only know what is available now, but what is waiting in the wings and they can guide you into a clinical trial best suited for you.

              My best wishes for you.

              Mary

              mary1233
              Participant

                I have been thinking about you. Having no known mutations is termed being a wild-type. The ipi anti PD1 that Artie mentioned has had a 61% response rate for melanoma wild types.

                Another interesting read is a woman named Patrica LoRusso. She is currently at Yale and is starting up what will be a multi center study to take the specific mutations of wild type patients who have not responded to immunotherapy and apply a personalized medicine approach to address whatever specific mutation they have.

                The whole treatment approach to cancer is changing.

                Best of luck.

                Mary

                mary1233
                Participant

                  I have been thinking about you. Having no known mutations is termed being a wild-type. The ipi anti PD1 that Artie mentioned has had a 61% response rate for melanoma wild types.

                  Another interesting read is a woman named Patrica LoRusso. She is currently at Yale and is starting up what will be a multi center study to take the specific mutations of wild type patients who have not responded to immunotherapy and apply a personalized medicine approach to address whatever specific mutation they have.

                  The whole treatment approach to cancer is changing.

                  Best of luck.

                  Mary

                  mary1233
                  Participant

                    I have been thinking about you. Having no known mutations is termed being a wild-type. The ipi anti PD1 that Artie mentioned has had a 61% response rate for melanoma wild types.

                    Another interesting read is a woman named Patrica LoRusso. She is currently at Yale and is starting up what will be a multi center study to take the specific mutations of wild type patients who have not responded to immunotherapy and apply a personalized medicine approach to address whatever specific mutation they have.

                    The whole treatment approach to cancer is changing.

                    Best of luck.

                    Mary

                    mary1233
                    Participant

                      I asked my oncologist at Sloan what is more relevant in relation to treatment – the fact that I have mucosal melanoma or the mutation status. He said, without a doubt, the mutation status.

                      I had surgery and chemo in 2012 and 2013 because the immunotherapy was not ready for me. So much has changed and Artie is right – the ipi – PD-1 combo results are very impressive.

                      I just hope you choose to go to a major research center. They not only know what is available now, but what is waiting in the wings and they can guide you into a clinical trial best suited for you.

                      My best wishes for you.

                      Mary

                      mary1233
                      Participant

                        I asked my oncologist at Sloan what is more relevant in relation to treatment – the fact that I have mucosal melanoma or the mutation status. He said, without a doubt, the mutation status.

                        I had surgery and chemo in 2012 and 2013 because the immunotherapy was not ready for me. So much has changed and Artie is right – the ipi – PD-1 combo results are very impressive.

                        I just hope you choose to go to a major research center. They not only know what is available now, but what is waiting in the wings and they can guide you into a clinical trial best suited for you.

                        My best wishes for you.

                        Mary

                      arthurjedi007
                      Participant

                        The best for all according to the numbers is ipi pd1 combo. But I don't believe they distinguish out mucosal. There are some severe but manageable side affects.

                        Jerry probably knows more about mucosal.

                        Artie

                        arthurjedi007
                        Participant

                          The best for all according to the numbers is ipi pd1 combo. But I don't believe they distinguish out mucosal. There are some severe but manageable side affects.

                          Jerry probably knows more about mucosal.

                          Artie

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