Miotic Rate – Pathology report ?

The mitotic rate is a measurement of how fast tumor cells are dividing.

Concerning your Mitotic rate or MR, 2/10 HPF is considered to be towards the low end of the spectrum. This means the rate at which the malignant cells are dividing below the epidermis. This is sometimes expressed as a number and the lower the number the better, as that means it is less likely the tumor has spread. Since there are currently no set guidelines in the U.S. and world as to how this should be reported, it also may not be a number as I have seen reports that may say absent, low, intermediate, medium, or high, and I have even seen "non conspicuous", and  the word "rare" also being used. The MR is measured by simply examining the excised tumor with a microscope and manually counting the number of cells exhibiting mitosis, an easily identifiable characteristic of dividing cells

This can also be expressed in what is called mitosis per mm2.

To convert:

1 HPF = .785 mm2

and 2 mitosis per/10 HPF= .2 per 1 HPF

and 10 HPF= 7.85 mm2

so .2 (20% of HPF) X 7.85 mm2 = 1.57 mitosis /mm2

Or as an equation the best I can type here:

2 mitosis/10hpf=x/7.85mm2 which equals =15.7/10x or 1.57 mitosis per mm2.

Michael

The mitotic rate is a measurement of how fast tumor cells are dividing.

Concerning your Mitotic rate or MR, 2/10 HPF is considered to be towards the low end of the spectrum. This means the rate at which the malignant cells are dividing below the epidermis. This is sometimes expressed as a number and the lower the number the better, as that means it is less likely the tumor has spread. Since there are currently no set guidelines in the U.S. and world as to how this should be reported, it also may not be a number as I have seen reports that may say absent, low, intermediate, medium, or high, and I have even seen "non conspicuous", and  the word "rare" also being used. The MR is measured by simply examining the excised tumor with a microscope and manually counting the number of cells exhibiting mitosis, an easily identifiable characteristic of dividing cells

This can also be expressed in what is called mitosis per mm2.

To convert:

1 HPF = .785 mm2

and 2 mitosis per/10 HPF= .2 per 1 HPF

and 10 HPF= 7.85 mm2

so .2 (20% of HPF) X 7.85 mm2 = 1.57 mitosis /mm2

Or as an equation the best I can type here:

2 mitosis/10hpf=x/7.85mm2 which equals =15.7/10x or 1.57 mitosis per mm2.

Michael