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Miotic Rate – Pathology report ?

Forums General Melanoma Community Miotic Rate – Pathology report ?

  • Post
    joy_
    Participant

    Is a miotic rate of 2/10hpf considered high or low?  Just curious because I don't understand this part of pathology report.

    Is a miotic rate of 2/10hpf considered high or low?  Just curious because I don't understand this part of pathology report.

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      MichaelFL
      Participant

      The mitotic rate is a measurement of how fast tumor cells are dividing.

      Concerning your Mitotic rate or MR, 2/10 HPF is considered to be towards the low end of the spectrum. This means the rate at which the malignant cells are dividing below the epidermis. This is sometimes expressed as a number and the lower the number the better, as that means it is less likely the tumor has spread. Since there are currently no set guidelines in the U.S. and world as to how this should be reported, it also may not be a number as I have seen reports that may say absent, low, intermediate, medium, or high, and I have even seen "non conspicuous", and  the word "rare" also being used. The MR is measured by simply examining the excised tumor with a microscope and manually counting the number of cells exhibiting mitosis, an easily identifiable characteristic of dividing cells

      This can also be expressed in what is called mitosis per mm2.

      To convert:

      1 HPF = .785 mm2

      and 2 mitosis per/10 HPF= .2 per 1 HPF

      and 10 HPF= 7.85 mm2

      so .2 (20% of HPF) X 7.85 mm2 = 1.57 mitosis /mm2

      Or as an equation the best I can type here:

      2 mitosis/10hpf=x/7.85mm2 which equals =15.7/10x or 1.57 mitosis per mm2.

      Michael

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      MichaelFL
      Participant

      The mitotic rate is a measurement of how fast tumor cells are dividing.

      Concerning your Mitotic rate or MR, 2/10 HPF is considered to be towards the low end of the spectrum. This means the rate at which the malignant cells are dividing below the epidermis. This is sometimes expressed as a number and the lower the number the better, as that means it is less likely the tumor has spread. Since there are currently no set guidelines in the U.S. and world as to how this should be reported, it also may not be a number as I have seen reports that may say absent, low, intermediate, medium, or high, and I have even seen "non conspicuous", and  the word "rare" also being used. The MR is measured by simply examining the excised tumor with a microscope and manually counting the number of cells exhibiting mitosis, an easily identifiable characteristic of dividing cells

      This can also be expressed in what is called mitosis per mm2.

      To convert:

      1 HPF = .785 mm2

      and 2 mitosis per/10 HPF= .2 per 1 HPF

      and 10 HPF= 7.85 mm2

      so .2 (20% of HPF) X 7.85 mm2 = 1.57 mitosis /mm2

      Or as an equation the best I can type here:

      2 mitosis/10hpf=x/7.85mm2 which equals =15.7/10x or 1.57 mitosis per mm2.

      Michael

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