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Melanoma regression w/ immunotherapy… Recent CT shows new mass

Forums General Melanoma Community Melanoma regression w/ immunotherapy… Recent CT shows new mass

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      Hello.  I started treatment in Nov 2019 for Stage IV melanoma.  I completed 4 cycles of opdivo/yervoy and was switched to monotherapy after that.  I was only able to undergo one infusion of monotherapy because I started having major adverse reactions (hypothyroidism, hepatitis, ketoacidosis – now type 1 diabetic, major vision issues).  I haven’t had any treatment since April 2020, but all my tumors have shown to continually shrink.

      I had scans this last weekend and my oncologist told me yesterday that they see a new mass in a lymph node in my lung.  He said he isn’t sure what it is, but it wasn’t previously present and they’re going to do a PET scan to see if there’s active disease.  If so, they’ll move forward with a biopsy.  My chart shows:  left hilar metastatic lymphadenopathy.  Does anyone have any insight on what this could possibly be?  My melanoma has shrunk since my last scans – so I’m afraid it’s not melanoma because I’ve been responding to treatment all along – why would I develop a new tumor?  Or is it possible that new melanoma tumors grow, even after responding well to immunotherapy in the past?

      Just wondering if anyone has experience or knowledge regarding such a thing… Thank you.

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