› Forums › General Melanoma Community › Mekinist
- This topic has 3 replies, 1 voice, and was last updated 10 years, 4 months ago by POW.
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- November 15, 2013 at 4:44 am
Hello well down to last treatment before chemo (which my dad won't do)is Mekinist. We cannot combine with the equivalent of zelboraf because his kidneys failed from that and he almost died from pd-1.
yeh, doesn't sound good. Had anyone been on just Mekinist and if so what were Side effects?
thanks much!!!!
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- November 15, 2013 at 1:11 pm
I don't recall anyone on this forum getting Mekinist (trametinib) alone, although DeniseK may be doing that now. We most often hear about patients who got the Taflinar + Mekinist combo. There was a Phase III clinical trial of Mekinist vs standard chemo (Flaherty et al, NEJM July 2012) that showed that Mekinist worked somewhat better than standard chemo, but not a lot better.
The most common adverse effects reported for the clinical trial were: "rash, diarrhea, peripheral edema, fatigue, and dermatitis acneiform; among the patients with rash, less than 8% had grade 3 or 4 rash. A decreased ejection fraction or ventricular dysfunction was observed in 14 patients (7%) in the trametinib group (11 with a decreased ejection fraction and 3 with left ventricular dysfunction).'
I hope this helps you.
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- November 15, 2013 at 1:11 pm
I don't recall anyone on this forum getting Mekinist (trametinib) alone, although DeniseK may be doing that now. We most often hear about patients who got the Taflinar + Mekinist combo. There was a Phase III clinical trial of Mekinist vs standard chemo (Flaherty et al, NEJM July 2012) that showed that Mekinist worked somewhat better than standard chemo, but not a lot better.
The most common adverse effects reported for the clinical trial were: "rash, diarrhea, peripheral edema, fatigue, and dermatitis acneiform; among the patients with rash, less than 8% had grade 3 or 4 rash. A decreased ejection fraction or ventricular dysfunction was observed in 14 patients (7%) in the trametinib group (11 with a decreased ejection fraction and 3 with left ventricular dysfunction).'
I hope this helps you.
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- November 15, 2013 at 1:11 pm
I don't recall anyone on this forum getting Mekinist (trametinib) alone, although DeniseK may be doing that now. We most often hear about patients who got the Taflinar + Mekinist combo. There was a Phase III clinical trial of Mekinist vs standard chemo (Flaherty et al, NEJM July 2012) that showed that Mekinist worked somewhat better than standard chemo, but not a lot better.
The most common adverse effects reported for the clinical trial were: "rash, diarrhea, peripheral edema, fatigue, and dermatitis acneiform; among the patients with rash, less than 8% had grade 3 or 4 rash. A decreased ejection fraction or ventricular dysfunction was observed in 14 patients (7%) in the trametinib group (11 with a decreased ejection fraction and 3 with left ventricular dysfunction).'
I hope this helps you.
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