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MEK/BRAF Combo Side Effects Role Call
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MEK/BRAF Combo Side Effects Role Call

› Forums › General Melanoma Community › MEK/BRAF Combo Side Effects Role Call

  • Post
    • April 17, 2011 at 7:24 pm
    mrsmarilyn
    Participant

      Hello Everyone.  My brother Gary going to SC in Nashville has been on the MEK/BRAF combo for about 2 months and is having frequent bouts of high fever and nausea.  He was on the Braf (GSK) initially and they moved him over to the combo – after the BRAF stopped working.  We were wondering if anyone else is having any similiar side effects, and how eveyone on this trial is doing.  On a good note-he has went from 7 spots – to only one stubborn one in the pelvic area.  Thanks and hope to hear from this oustanding group of brave people, we have grown to love and depend o

      Hello Everyone.  My brother Gary going to SC in Nashville has been on the MEK/BRAF combo for about 2 months and is having frequent bouts of high fever and nausea.  He was on the Braf (GSK) initially and they moved him over to the combo – after the BRAF stopped working.  We were wondering if anyone else is having any similiar side effects, and how eveyone on this trial is doing.  On a good note-he has went from 7 spots – to only one stubborn one in the pelvic area.  Thanks and hope to hear from this oustanding group of brave people, we have grown to love and depend on.

      Best regards,

      MrsMarilyn

      Sister of Gary Stage IV

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    • Replies
        • April 17, 2011 at 8:15 pm
        mommydog
        Participant

          My husband has been on GSK Braf/Mek for about 4 weeks.  Four hours after taking his Braf dose (without MEK) he often develops chills and a fever up to about 102.  That lasts for about 3 to 4 hours.  It doesn't happen every day, and when it does happen, is worse some days than others. That's the only side effect so far–no nausea and no rash.

           

          Deborah

            • April 17, 2011 at 9:36 pm
            dawn dion
            Participant

              I have been on GSK BRAF/MEK for about 6 or 7 weeks – three weeks in i ran fevers of anywhere from 99.9 to 103 for a week straight – because they got so high they took me off for a few days and slowly started me back on – since then I have had about a week of my hair "shedding", has since stopped and other than that all seems to be fine.   Go for my scans on the 28th and I am starting to get a little freaked out – only had one small spot in the lymph node in my chest wall when I started BRAF/MEK- hoping for good results.    Best of luck to you.

              • April 18, 2011 at 12:16 am
              mrsmarilyn
              Participant

                Hi-Thanks so much for letting us know–and you will do great on the 28th – keep us posted!!

                MrsMarilyn

                • April 18, 2011 at 12:16 am
                mrsmarilyn
                Participant

                  Hi-Thanks so much for letting us know–and you will do great on the 28th – keep us posted!!

                  MrsMarilyn

                  • April 17, 2011 at 9:36 pm
                  dawn dion
                  Participant

                    I have been on GSK BRAF/MEK for about 6 or 7 weeks – three weeks in i ran fevers of anywhere from 99.9 to 103 for a week straight – because they got so high they took me off for a few days and slowly started me back on – since then I have had about a week of my hair "shedding", has since stopped and other than that all seems to be fine.   Go for my scans on the 28th and I am starting to get a little freaked out – only had one small spot in the lymph node in my chest wall when I started BRAF/MEK- hoping for good results.    Best of luck to you.

                    • April 18, 2011 at 12:17 am
                    mrsmarilyn
                    Participant

                      Thanks for letting us know!!!  Best of luck and keep in touch.

                      MrsMarilyn

                      • April 18, 2011 at 12:17 am
                      mrsmarilyn
                      Participant

                        Thanks for letting us know!!!  Best of luck and keep in touch.

                        MrsMarilyn

                      • April 17, 2011 at 8:15 pm
                      mommydog
                      Participant

                        My husband has been on GSK Braf/Mek for about 4 weeks.  Four hours after taking his Braf dose (without MEK) he often develops chills and a fever up to about 102.  That lasts for about 3 to 4 hours.  It doesn't happen every day, and when it does happen, is worse some days than others. That's the only side effect so far–no nausea and no rash.

                         

                        Deborah

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