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MDX-1105 – anybody on it?
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MDX-1105 – anybody on it?

› Forums › General Melanoma Community › MDX-1105 – anybody on it?

  • Post
    • April 4, 2012 at 7:27 pm
    MeNDave
    Participant

      Dave decided today to wait to start IPI – and his oncologist agreed.  Khushalani believes that the new mets, although numerous, are tiny, and that he has time to see if he can get into a clinical trial.  After speaking with his mel cohorts, he agreed the anti-pd1/pdl-1s were his best bet.  Our first stop is with Dr.

      Dave decided today to wait to start IPI – and his oncologist agreed.  Khushalani believes that the new mets, although numerous, are tiny, and that he has time to see if he can get into a clinical trial.  After speaking with his mel cohorts, he agreed the anti-pd1/pdl-1s were his best bet.  Our first stop is with Dr. Ma at Roswell, who is doing the MDX-1105 trial.  This also happened to be my brother Mike's doctor when he was still with us.  I liked the way he treated my brother (who was borderline mentally handicapped), who had absolutely no hope, but tried everything he could, knowing Mike wanted to keep trying.  Then on Thursday of next week we travel to University of Pitt's Hillman Cancer Center to see Dr. Tahrini, to see if they have anything to offer him.  Either way, we walked out of this appointment with some hope – and that can go along way.

      I know how the studies on the 1106 are going, but is anybody doing the 1105?

      Please keep your fingers crossed –

      Maria

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    • Replies
        • April 4, 2012 at 8:13 pm
        killmel
        Participant

           

          I am glad you are feeling hopeful. Is this the trial for MDX 1105 anti-pdl-1 that you are considering. This is NOT a anti-PD1 trial.

          http://clinicaltrials.gov/ct2/show/NCT00729664

          This PHASE 1 trial has been going  since 2008 for "selected advanced or recurrent solid tumors." It is my understanding that melanoma is only one of the cancers being tested.  Since this trial has been going of for years, perhaps your doctor knows how patients are doing with this drug.

          I am not sure the difference between anti-pd1 vs anti-pdl1. Perhaps Jimmy B can explain the difference.

           

          Good Luck

          • April 4, 2012 at 8:13 pm
          killmel
          Participant

             

            I am glad you are feeling hopeful. Is this the trial for MDX 1105 anti-pdl-1 that you are considering. This is NOT a anti-PD1 trial.

            http://clinicaltrials.gov/ct2/show/NCT00729664

            This PHASE 1 trial has been going  since 2008 for "selected advanced or recurrent solid tumors." It is my understanding that melanoma is only one of the cancers being tested.  Since this trial has been going of for years, perhaps your doctor knows how patients are doing with this drug.

            I am not sure the difference between anti-pd1 vs anti-pdl1. Perhaps Jimmy B can explain the difference.

             

            Good Luck

            • April 4, 2012 at 8:13 pm
            killmel
            Participant

               

              I am glad you are feeling hopeful. Is this the trial for MDX 1105 anti-pdl-1 that you are considering. This is NOT a anti-PD1 trial.

              http://clinicaltrials.gov/ct2/show/NCT00729664

              This PHASE 1 trial has been going  since 2008 for "selected advanced or recurrent solid tumors." It is my understanding that melanoma is only one of the cancers being tested.  Since this trial has been going of for years, perhaps your doctor knows how patients are doing with this drug.

              I am not sure the difference between anti-pd1 vs anti-pdl1. Perhaps Jimmy B can explain the difference.

               

              Good Luck

                • April 4, 2012 at 8:17 pm
                killmel
                Participant

                  Maria,

                   

                  Do you know what the protocol for this trial is?? Do you need to do a biopsy to qualify for this trial??

                   

                  Doug

                  • April 4, 2012 at 8:17 pm
                  killmel
                  Participant

                    Maria,

                     

                    Do you know what the protocol for this trial is?? Do you need to do a biopsy to qualify for this trial??

                     

                    Doug

                    • April 4, 2012 at 8:17 pm
                    killmel
                    Participant

                      Maria,

                       

                      Do you know what the protocol for this trial is?? Do you need to do a biopsy to qualify for this trial??

                       

                      Doug

                      • April 4, 2012 at 11:56 pm
                      MeNDave
                      Participant

                        You do not need a biopsy for mutation testing.  It is an anti-pdl1 drug.  From how Dave's oncologist described it, the anti-pd1 is like a bolt – and the anti-pdl1 is the nut.  With out the both of them, they don't work – so if you disrupt one, it allows the immune system to attack it.

                        The main criteria for this is no previous monoclonal antibodies, which would include IPI or any other anti-pd1 drug.  It is a multicenter trial, so if you click on the link above, you should be able to find out if it's in your area.  As far as numbers reported for response rates, we'll see if we can get that out the trial doc.

                        • April 4, 2012 at 11:56 pm
                        MeNDave
                        Participant

                          You do not need a biopsy for mutation testing.  It is an anti-pdl1 drug.  From how Dave's oncologist described it, the anti-pd1 is like a bolt – and the anti-pdl1 is the nut.  With out the both of them, they don't work – so if you disrupt one, it allows the immune system to attack it.

                          The main criteria for this is no previous monoclonal antibodies, which would include IPI or any other anti-pd1 drug.  It is a multicenter trial, so if you click on the link above, you should be able to find out if it's in your area.  As far as numbers reported for response rates, we'll see if we can get that out the trial doc.

                          • April 4, 2012 at 11:56 pm
                          MeNDave
                          Participant

                            You do not need a biopsy for mutation testing.  It is an anti-pdl1 drug.  From how Dave's oncologist described it, the anti-pd1 is like a bolt – and the anti-pdl1 is the nut.  With out the both of them, they don't work – so if you disrupt one, it allows the immune system to attack it.

                            The main criteria for this is no previous monoclonal antibodies, which would include IPI or any other anti-pd1 drug.  It is a multicenter trial, so if you click on the link above, you should be able to find out if it's in your area.  As far as numbers reported for response rates, we'll see if we can get that out the trial doc.

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