MRF-Logo2019-Horizontal-RGB
Last combo infusion
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Last combo infusion

› Forums › General Melanoma Community › Last combo infusion

  • Post
    • August 6, 2021 at 3:34 pm
    Christinad
    Participant
      Hi All –

      Tomorrow is the last of the combo infusion of ipi/nivo. I’ve had a hard time with side effects which included one hospital admission.  Just wondering if anyone experienced less side effects after going to the single medication cycle 5? I know everyone is different and have a range of different side effects from minimal to a lot. My question is for those of you who had significant side effects cycle 1-4 did you find any relief thereafter?

    Viewing 5 reply threads
    • Replies
        • August 7, 2021 at 11:40 am
        hxcadam
        Participant
          Everyone is different but many patients who go on to do single Opdivo infusions have a much easier time than with the combo.  Ipilimumab is considered the bad boy but sadly a necessary evil.
          • August 7, 2021 at 5:06 pm
          Christinad
          Participant
            Thank you for your response. I’m hoping that’ll be the case for me.
            • August 9, 2021 at 2:30 pm
            JudiAU
            Participant
              I completed four combos with a short break for a one week hospital admission for high fevers. Followed by brain surgery for met removal and brief radiation. Returned for single therapy and finish next month. The single dose is much easier IMHO. I did eventually have some mild diarrhea but it was manageable and eventually went away, not like what some people experience. I was on low steroids for most of the time. Good luck.
              • August 12, 2021 at 6:33 pm
              Christinad
              Participant
                Thank you for your response. I’m truly miserable. Praying this gets easier.
                • August 13, 2021 at 8:07 am
                Beany
                Participant
                  Hello,

                  I only got through three combos before having drug induced liver damage or very high AST and ALT. ALT was 748. I  was in hospital gor two months and steroids for one year.

                  I am on the single dose of opdivo now and have zero side effects.

                  Regards,

                  • August 13, 2021 at 9:59 am
                  Christinad
                  Participant
                    Wow, I’m sorry to hear you had such a hard time with the combo dose. A 2 month hospital had to be awful! You’re a trooper and such a strong person! So glad you’re tolerating the opdivo well with no side effects.
                Viewing 5 reply threads
                • You must be logged in to reply to this topic.
                About the MRF Patient Forum

                The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

                The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.