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KRAS nonBRAF melanoma mutation treatment options
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KRAS nonBRAF melanoma mutation treatment options

› Forums › General Melanoma Community › KRAS nonBRAF melanoma mutation treatment options

  • Post
    • April 18, 2014 at 10:37 pm
    jjw2014
    Participant

      My sister was informed today that she has a Negative BRAF gene mutation KRAS.  SHe's not eligible for many clinical trials because her mutation is rare.  Would like to know if any others share this same type of mutation and if so what treatment option they tried.  

       

      We are thinking of doing the IL2 first, then move to Yervoy, and hope that later on in the summer she will be eligible for a antipd1.  

       

      Can anyone give any advice on their cancer or a loved ones?

       

      We need just a glimmer of hope..

       

      PS her husband also has Melanoma stage 4 and so you can imagine how heartbreaking all this is with having 2 small children.

       

      BTW she is 46, no other health issues, good shape, liver nodule is 3cm and the lungs are even detectable.

       

       

    Viewing 2 reply threads
    • Replies
        • April 21, 2014 at 4:08 pm
        mary1233
        Participant

          I also am Braf negative – they refer to it as wild type meaning essentially none of the above.

           

          Sloan Kettering is registering Braf negative wild type patients for a drug combo trial using trametinib and something that has not been FDA approved yet.

          It's on their website under melanoma oncologists Paul Chapman and Michael Postow. I also saw something similar at another cancer center but am not sure where.

           

          Hope this helps.

            • April 24, 2014 at 9:48 pm
            jjw2014
            Participant

              how long have you had your Melanoma?  Stage?  What are you doing to treat it?

               

              Thanks

              Jennifer

              • April 24, 2014 at 9:48 pm
              jjw2014
              Participant

                how long have you had your Melanoma?  Stage?  What are you doing to treat it?

                 

                Thanks

                Jennifer

                • April 24, 2014 at 9:48 pm
                jjw2014
                Participant

                  how long have you had your Melanoma?  Stage?  What are you doing to treat it?

                   

                  Thanks

                  Jennifer

                • April 21, 2014 at 4:08 pm
                mary1233
                Participant

                  I also am Braf negative – they refer to it as wild type meaning essentially none of the above.

                   

                  Sloan Kettering is registering Braf negative wild type patients for a drug combo trial using trametinib and something that has not been FDA approved yet.

                  It's on their website under melanoma oncologists Paul Chapman and Michael Postow. I also saw something similar at another cancer center but am not sure where.

                   

                  Hope this helps.

                  • April 21, 2014 at 4:08 pm
                  mary1233
                  Participant

                    I also am Braf negative – they refer to it as wild type meaning essentially none of the above.

                     

                    Sloan Kettering is registering Braf negative wild type patients for a drug combo trial using trametinib and something that has not been FDA approved yet.

                    It's on their website under melanoma oncologists Paul Chapman and Michael Postow. I also saw something similar at another cancer center but am not sure where.

                     

                    Hope this helps.

                Viewing 2 reply threads
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