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Is there any advantage to four combo infusions over three?

Forums General Melanoma Community Is there any advantage to four combo infusions over three?

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      Hello everyone,

      I will have bloodwork and see the oncologist this Wednesday to see if I can go onto the final infusion of the nivo/ipi combo. I am happy to have done three of these, and an xray has already shown shrinkage of the biggest tumor in my lung.
      I kindly received some good stats and links (thanks to Celeste and Ed) about clinical trials of the combo which indicated that even if you don’t do all the infusions, the response rates are somewhat similar. Therefore, I was wondering why risk toxicity to do the fourth infusion?
      I do want to do number four, but those stats have got me thinking.
      Any input welcome.

      Thank you,

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          Here is a complete breakdown of the data:

          Hope that helps. Celeste

              Wonderful Celeste! Your final comment in the link answers my question. Thank you again,
              Adam, if you want to share, what did you decide?
                  The doctor won’t let me decide at this stage. He wants me to do four combos and is waiting for the liver numbers to come down. I would like to do four infusions but feel going on opdivo mono would be better than risking another spike in enzymes by doing the combo. If I could choose, I think I would skip number four and do maintenance only.
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