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ipi reinduction failure

Forums General Melanoma Community ipi reinduction failure

  • Post
    beatricefromPARIS
    Participant

      Hi all,

      After good response to IPI 1, I had reinduction but all existing mets have now progressed at 3 months of IPI 2 (no new ones).

      Onc team has concluded that Vemurafenib is to be started.

      I can't find any data on IPI reinduction rates of success so I would welcome your experience for a little on-line survey!

      Beatrice, stage IV since Feb 2009 (6 different treatments so far)

      Hi all,

      After good response to IPI 1, I had reinduction but all existing mets have now progressed at 3 months of IPI 2 (no new ones).

      Onc team has concluded that Vemurafenib is to be started.

      I can't find any data on IPI reinduction rates of success so I would welcome your experience for a little on-line survey!

      Beatrice, stage IV since Feb 2009 (6 different treatments so far)

    Viewing 2 reply threads
    • Replies
        Gene_S
        Participant

          Beatrice,

          Were your ippi dosages at the 3 mg/kg or 10 mg/kg ?

          My oncologist has stated to me that the higher dosage patients

          are having better success rates.  Possibly if you were on the low dosages

          of ippi they could try the higher dosage before trying the Vemurafenib?

          I am currently on a clinical trial with the high dosage and GM-CSF (sub q shots 14 days on and then 7 off

          for the whole time)  and so far my tumors are shrinking.  I am in the maintenance phase of the Ippi getting

          infusions every 12 weeks (after the initial every 3 weeks for 12 weeks).   I had tumors in liver, lungs and one on

          the scalp at cervical spine C1-2 pressing  and inoperable because of the close proximity to the spine.

           The ones in my lungs are gone as well as the one on my scalp.  The one on the liver is still

          there but has shrunk.  I will be going for another Ippi maintenance infusion in April.  I also believe that having a

          high Vitamin D3 and high CoQ10 (Ubiquinol) count has helped with my success.  Both Vitamin D3 and CoQ10

          results are done by blood testing.  If interested in Vitamin D3 do a search on my user name for more information.

           

          Best Wishes,

          Gene

          Gene_S
          Participant

            Beatrice,

            Were your ippi dosages at the 3 mg/kg or 10 mg/kg ?

            My oncologist has stated to me that the higher dosage patients

            are having better success rates.  Possibly if you were on the low dosages

            of ippi they could try the higher dosage before trying the Vemurafenib?

            I am currently on a clinical trial with the high dosage and GM-CSF (sub q shots 14 days on and then 7 off

            for the whole time)  and so far my tumors are shrinking.  I am in the maintenance phase of the Ippi getting

            infusions every 12 weeks (after the initial every 3 weeks for 12 weeks).   I had tumors in liver, lungs and one on

            the scalp at cervical spine C1-2 pressing  and inoperable because of the close proximity to the spine.

             The ones in my lungs are gone as well as the one on my scalp.  The one on the liver is still

            there but has shrunk.  I will be going for another Ippi maintenance infusion in April.  I also believe that having a

            high Vitamin D3 and high CoQ10 (Ubiquinol) count has helped with my success.  Both Vitamin D3 and CoQ10

            results are done by blood testing.  If interested in Vitamin D3 do a search on my user name for more information.

             

            Best Wishes,

            Gene

              beatricefromPARIS
              Participant

                Hi Gene

                I had 4x3mg and 4x3mg at reinduction.

                I take vit D3 supplements under medical prescription .

                I will have a look at Q10. Someone mentioned vit K1 also.

                but I prefer not taking supplements without dr's approval!

                Beatrice

                beatricefromPARIS
                Participant

                  Hi Gene

                  I had 4x3mg and 4x3mg at reinduction.

                  I take vit D3 supplements under medical prescription .

                  I will have a look at Q10. Someone mentioned vit K1 also.

                  but I prefer not taking supplements without dr's approval!

                  Beatrice

                  beatricefromPARIS
                  Participant

                    Hi Gene

                    I had 4x3mg and 4x3mg at reinduction.

                    I take vit D3 supplements under medical prescription .

                    I will have a look at Q10. Someone mentioned vit K1 also.

                    but I prefer not taking supplements without dr's approval!

                    Beatrice

                  Gene_S
                  Participant

                    Beatrice,

                    Were your ippi dosages at the 3 mg/kg or 10 mg/kg ?

                    My oncologist has stated to me that the higher dosage patients

                    are having better success rates.  Possibly if you were on the low dosages

                    of ippi they could try the higher dosage before trying the Vemurafenib?

                    I am currently on a clinical trial with the high dosage and GM-CSF (sub q shots 14 days on and then 7 off

                    for the whole time)  and so far my tumors are shrinking.  I am in the maintenance phase of the Ippi getting

                    infusions every 12 weeks (after the initial every 3 weeks for 12 weeks).   I had tumors in liver, lungs and one on

                    the scalp at cervical spine C1-2 pressing  and inoperable because of the close proximity to the spine.

                     The ones in my lungs are gone as well as the one on my scalp.  The one on the liver is still

                    there but has shrunk.  I will be going for another Ippi maintenance infusion in April.  I also believe that having a

                    high Vitamin D3 and high CoQ10 (Ubiquinol) count has helped with my success.  Both Vitamin D3 and CoQ10

                    results are done by blood testing.  If interested in Vitamin D3 do a search on my user name for more information.

                     

                    Best Wishes,

                    Gene

                Viewing 2 reply threads
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