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IPI/Pembro trial – What to expect
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IPI/Pembro trial – What to expect

› Forums › General Melanoma Community › IPI/Pembro trial – What to expect

  • Post
    • November 6, 2016 at 11:43 pm
    jvictoria
    Participant

      Hi everyone,

      Well, ended Nivo trial in June because of side effects and two small spots showing up in the lung. Subsequent follow up CT scans in August showed significant shrinkage; PET scan showed no uptake. Unfortunatly, CT scans last week showed significant growth of the lung nodules and a new spot on the liver.

      Doctors have recommended a low dose IPI/Pembro trial so I was wondering if any of you have had experience with the combo. Looking to find out what to expect. Plan is to start the trial this Tuesday.

      Any other thoughts are very welcomed also.

      Thanks

    Viewing 5 reply threads
    • Replies
        • November 7, 2016 at 1:51 am
        geriakt
        Participant

          Good luck Juan

          Prayers your way 

          • November 7, 2016 at 1:51 am
          geriakt
          Participant

            Good luck Juan

            Prayers your way 

            • November 7, 2016 at 1:51 am
            geriakt
            Participant

              Good luck Juan

              Prayers your way 

              • November 7, 2016 at 4:31 pm
              debwray
              Participant

                Hi Juan,

                ipi/ pembro sounds good. Pembro as sole agent seems to have marginally better results than nivo.- both are PD1 drugs. Ipi with a PD1 gets good response rates but higher side effects than either drug on its own.

                Are we talking ipi 1mg per kilo or 3 mg per kilo ? original trials had 10mg kilo but 3 now seems to be standard-?  Would expect side effects to miiror ipi nivo combo.

                Good Luck

                 

                Deb

                 

                 

                  • November 7, 2016 at 6:11 pm
                  jvictoria
                  Participant

                    Thanks Deb… Will be taking IPI at the 1mg per kilo dosage

                    • November 7, 2016 at 6:11 pm
                    jvictoria
                    Participant

                      Thanks Deb… Will be taking IPI at the 1mg per kilo dosage

                      • November 7, 2016 at 6:11 pm
                      jvictoria
                      Participant

                        Thanks Deb… Will be taking IPI at the 1mg per kilo dosage

                      • November 7, 2016 at 4:31 pm
                      debwray
                      Participant

                        Hi Juan,

                        ipi/ pembro sounds good. Pembro as sole agent seems to have marginally better results than nivo.- both are PD1 drugs. Ipi with a PD1 gets good response rates but higher side effects than either drug on its own.

                        Are we talking ipi 1mg per kilo or 3 mg per kilo ? original trials had 10mg kilo but 3 now seems to be standard-?  Would expect side effects to miiror ipi nivo combo.

                        Good Luck

                         

                        Deb

                         

                         

                        • November 7, 2016 at 4:31 pm
                        debwray
                        Participant

                          Hi Juan,

                          ipi/ pembro sounds good. Pembro as sole agent seems to have marginally better results than nivo.- both are PD1 drugs. Ipi with a PD1 gets good response rates but higher side effects than either drug on its own.

                          Are we talking ipi 1mg per kilo or 3 mg per kilo ? original trials had 10mg kilo but 3 now seems to be standard-?  Would expect side effects to miiror ipi nivo combo.

                          Good Luck

                           

                          Deb

                           

                           

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