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ipi/nivo trial
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ipi/nivo trial

› Forums › General Melanoma Community › ipi/nivo trial

  • Post
    • August 25, 2015 at 2:59 am
    momof4boys
    Participant

      So I am awaiting a bronchoscopy this week to biopsy the enlarged lymph nodes in my chest and would like to think about possible treatment plans that way if it is positive then I can have a somewhat educated conversation about treatment rather than being confused. So I've already had ipi the 3mg arm of the ipi/interferon trial. I finished all doses. So I've been reading here the last 2 years trying to keep informed on different trials/drugs. So since I've had ipi already does that mean I wouldn't be able to do the ipi/nivo trial and is that trial even available. I live around Omaha and would possibly be able to travel some, it might be pretty hard to do that all the time I guess cuz of my kids but what other trials are showing promising? I agree with what Celeste told me about trying a trial first so an anti-pd1 doesn't disqualify me for something else. I would sure appreciate any and all thoughts about what might be a possible game plan from some of you stage 4 people. Thanks

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    • Replies
        • August 25, 2015 at 8:04 pm
        kylez
        Participant

          Jimmy Carter's going the PD1 route… he's got some of the best docs. Albeit he does have brain mets so that would make a clinical trial hard. But PD1 alone has got to be a pretty viable option too. I fly 550 miles (short hop) every 2 weeks for my trial. Have been doing it for 17 months now, at first as overnight trips and now as day trips. I will say I have no depenents to take care of.

            • August 25, 2015 at 8:11 pm
            dfeng
            Participant

              why brain mets make a clinical trial hard?

              • August 25, 2015 at 9:31 pm
              BrianP
              Participant

                D. Feng,

                Many trials when they define their exclusion criteria it will list brain mets as one of the exclusions.  This seems to have become a little more relaxed over the last couple years as they have discovered immunotherapy can cross the brain barrier.  Many now will say something like no more than 3 brain mets and none bigger than .5 cm or something like that.

                Brian

                • August 25, 2015 at 9:31 pm
                BrianP
                Participant

                  D. Feng,

                  Many trials when they define their exclusion criteria it will list brain mets as one of the exclusions.  This seems to have become a little more relaxed over the last couple years as they have discovered immunotherapy can cross the brain barrier.  Many now will say something like no more than 3 brain mets and none bigger than .5 cm or something like that.

                  Brian

                  • August 25, 2015 at 9:31 pm
                  BrianP
                  Participant

                    D. Feng,

                    Many trials when they define their exclusion criteria it will list brain mets as one of the exclusions.  This seems to have become a little more relaxed over the last couple years as they have discovered immunotherapy can cross the brain barrier.  Many now will say something like no more than 3 brain mets and none bigger than .5 cm or something like that.

                    Brian

                    • August 25, 2015 at 8:11 pm
                    dfeng
                    Participant

                      why brain mets make a clinical trial hard?

                      • August 25, 2015 at 8:11 pm
                      dfeng
                      Participant

                        why brain mets make a clinical trial hard?

                      • August 25, 2015 at 8:04 pm
                      kylez
                      Participant

                        Jimmy Carter's going the PD1 route… he's got some of the best docs. Albeit he does have brain mets so that would make a clinical trial hard. But PD1 alone has got to be a pretty viable option too. I fly 550 miles (short hop) every 2 weeks for my trial. Have been doing it for 17 months now, at first as overnight trips and now as day trips. I will say I have no depenents to take care of.

                        • August 25, 2015 at 8:04 pm
                        kylez
                        Participant

                          Jimmy Carter's going the PD1 route… he's got some of the best docs. Albeit he does have brain mets so that would make a clinical trial hard. But PD1 alone has got to be a pretty viable option too. I fly 550 miles (short hop) every 2 weeks for my trial. Have been doing it for 17 months now, at first as overnight trips and now as day trips. I will say I have no depenents to take care of.

                          • August 25, 2015 at 9:35 pm
                          BrianP
                          Participant

                            I also agree with Kyle than Anti-PD1 would be a great option.  Don't think because you've tried ipi that you would automatically be disqualified for a ipi/nivo trial.  Trials often create subset categories within the trial.  In your case they might want to see how people do on the combo who progressed on ipi alone.  Not saying they have an arm like that but it's possible.

                             

                              • August 25, 2015 at 10:39 pm
                              dfeng
                              Participant

                                agree, give a try doesn't hurt.

                                • August 25, 2015 at 10:39 pm
                                dfeng
                                Participant

                                  agree, give a try doesn't hurt.

                                  • August 25, 2015 at 10:39 pm
                                  dfeng
                                  Participant

                                    agree, give a try doesn't hurt.

                                  • August 25, 2015 at 9:35 pm
                                  BrianP
                                  Participant

                                    I also agree with Kyle than Anti-PD1 would be a great option.  Don't think because you've tried ipi that you would automatically be disqualified for a ipi/nivo trial.  Trials often create subset categories within the trial.  In your case they might want to see how people do on the combo who progressed on ipi alone.  Not saying they have an arm like that but it's possible.

                                     

                                    • August 25, 2015 at 9:35 pm
                                    BrianP
                                    Participant

                                      I also agree with Kyle than Anti-PD1 would be a great option.  Don't think because you've tried ipi that you would automatically be disqualified for a ipi/nivo trial.  Trials often create subset categories within the trial.  In your case they might want to see how people do on the combo who progressed on ipi alone.  Not saying they have an arm like that but it's possible.

                                       

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