A WEB search of Jeff Patterson and Melanoma found many interesting articles.
http://mpip.org/articles/alt.html
Author: Jeff Patterson Date: January 8, 1996 –>
A WEB search of Jeff Patterson and Melanoma found many interesting articles.
http://mpip.org/articles/alt.html
Author: Jeff Patterson Date: January 8, 1996 –>
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* CITATIONS AND ABSTRACTS *
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* FROM THE NCI'S CANCERLIT DATABASE *
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21
UI - 95183366
AU - Prasad KN; Hernandez C; Edwards-Prasad J; Nelson J; Borus T; Robinson WA
TI - Modification of the effect of tamoxifen, cis-platin, DTIC, and interferon
-
-alpha 2b on human melanoma cells in culture by a mixture of vitamins.
SO - Nutr Cancer 1994;22(3):233-45
AD - Department of Radiology, University of Colorado Health Sciences Center,
Denver 80262.
AB - The effect of a mixture of vitamins in modifying the efficacy of
commonly used drugs in the treatment of human melanoma has not been
studied. Vitamin C and d-alpha-tocopheryl succinate (alpha-TS) alone
reduced the growth of human melanoma (SK-30) cells in culture,
whereas beta-carotene (BC), 13-cis-retinoic acid (RA), or sodium
selenite alone was ineffective. RA caused morphological changes, as
evidenced by flattening of cells and formation of short cytoplasmic
processes. A mixture of four vitamins (vitamin C, BC, alpha-TS, and
RA) was more effective in reducing growth of human melanoma cells
than a mixture of three vitamins. The growth-inhibitory effect of
cis-platin, decarbazine, tamoxifen, and recombinant interferon-alpha
2b was enhanced by vitamin C alone, a mixture of three vitamins (BC,
alpha-TS, and RA), and a mixture of four vitamins (vitamin C, BC,
alpha-TS, and RA) that contained 50 micrograms/ml of vitamin C. These
data show that a mixture of three or four vitamins can enhance the
growth-inhibitory effect of currently used chemotherapeutic agents on
human melanoma cells.
.
