Immunotherapy + T-VEC

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Immunotherapy + T-VEC

This topic has 5 replies, 3 voices, and was last updated 6 months ago by ed williams.

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- October 27, 2023 at 8:51 pm
- Quote
MB
Participant
Hello, my wife is stage IV and the melanoma is spreading quickly. She just had a 2nd cycle of ipi/nivo and so far we haven’t seen any indication that it’s working. We met with her oncologist today, who mentioned T-VEC but said she would have to stop ipi/nivo in order to do it. However, I read that others have done t-vec combined with immunotherapy with success. Bubbles and Ed- and anyone else!- do you know what immunotherapies can be combined with t-vec? Fortunately, we have an appointment scheduled with a melanoma specialist from Emory University Hospital next Friday- so we will of course ask him. But just thought I’d reach out to the forum in the meantime. Thanks to all, MB

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Replies

- - October 27, 2023 at 10:22 pm
  - Quote
  Bubbles
  Participant
  Your local onc really needs to get on top of the current treatments for melanoma if they are going to treat melanoma patients! Here is a link that says a great deal – with more within:
  Intratumoral or Intralesional therapy for melanoma – again. Yep, AGAIN!!! ASCO 2021, here we go!
  
  Hope you can attain some good options at Emory. c
  - October 28, 2023 at 3:13 pm
    
    Quote
    MB
    Participant
    
    Thank you, Celeste! Wow, very concerning that our local oncologist did not know this. Scary, honestly. Thank God for melanoma specialists!-MB
- - October 30, 2023 at 8:12 pm
  - Quote
  ed williams
  Participant
  MB, this is Onclive peer panel doctor from Moffitt talking about how they use T-vec, May of 2023 video. https://www.onclive.com/view/tumor-directed-oncolytic-therapies-for-melanoma-and-cscc
- - October 30, 2023 at 8:18 pm
  - Quote
  ed williams
  Participant
  MB, this is another injectable called RP1 and is in clinical trial called IGNYTE. Dr. Pavlick from Cornell Medicine talks about how it works in following short video. https://www.onclive.com/view/dr-pavlick-on-the-mechanisms-of-action-of-rp1-in-cutaneous-melanoma
- - October 30, 2023 at 8:27 pm
  - Quote
  ed williams
  Participant
  MB, last video on the topic from ASCO 2022. https://ascopost.com/news/september-2022/addition-of-t-vec-to-pembrolizumab-in-advanced-melanoma/

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