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IL-12 (new) and pembrolizumab, could be an interesting clinical trial….
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IL-12 (new) and pembrolizumab, could be an interesting clinical trial….

› Forums › General Melanoma Community › IL-12 (new) and pembrolizumab, could be an interesting clinical trial….

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      • November 30, 2014 at 5:43 pm
      arthurjedi007
      Participant

        Sounds interesting. It really makes sense to have a medicine (ie: IL 12) that creates the antibody and stuff cells. Then pd1 to make use of those cells. Granted if I understand it right cause most of this stuff goes over my head.

        I can only find the IL12 phase 2 solo trial though NCT01502293. Not sure what the one is that adds keytruda pd1.

        Artie

         

        • November 30, 2014 at 5:43 pm
        arthurjedi007
        Participant

          Sounds interesting. It really makes sense to have a medicine (ie: IL 12) that creates the antibody and stuff cells. Then pd1 to make use of those cells. Granted if I understand it right cause most of this stuff goes over my head.

          I can only find the IL12 phase 2 solo trial though NCT01502293. Not sure what the one is that adds keytruda pd1.

          Artie

           

          • November 30, 2014 at 5:43 pm
          arthurjedi007
          Participant

            Sounds interesting. It really makes sense to have a medicine (ie: IL 12) that creates the antibody and stuff cells. Then pd1 to make use of those cells. Granted if I understand it right cause most of this stuff goes over my head.

            I can only find the IL12 phase 2 solo trial though NCT01502293. Not sure what the one is that adds keytruda pd1.

            Artie

             

            • December 1, 2014 at 10:28 am
            JustMeInCA
            Participant

              Dr. Algazi, the one leading the study at UCSF, is one of my dad's doctors. He told me about it a couple months ago and is really excited. I actually thought it might have started already since he had said something about the end of the year.

              Interestingly enough, he had said that if Dad doesn't seem to respond to Keytruda alone, this might be a possibility for him. I haven't seen any of the selection criteria, and Dr. Algazi might not have either at that point, but it would be interesting if they accepted people who might have had at least a partial response on Keytruda. It does seem like participants would need to be PD-L1 positive from what the article says. 

              I'll be seeing Dr. Algazi in a few hours, so I'll try to remember to ask him about this. 

              • December 1, 2014 at 10:28 am
              JustMeInCA
              Participant

                Dr. Algazi, the one leading the study at UCSF, is one of my dad's doctors. He told me about it a couple months ago and is really excited. I actually thought it might have started already since he had said something about the end of the year.

                Interestingly enough, he had said that if Dad doesn't seem to respond to Keytruda alone, this might be a possibility for him. I haven't seen any of the selection criteria, and Dr. Algazi might not have either at that point, but it would be interesting if they accepted people who might have had at least a partial response on Keytruda. It does seem like participants would need to be PD-L1 positive from what the article says. 

                I'll be seeing Dr. Algazi in a few hours, so I'll try to remember to ask him about this. 

                • December 1, 2014 at 10:28 am
                JustMeInCA
                Participant

                  Dr. Algazi, the one leading the study at UCSF, is one of my dad's doctors. He told me about it a couple months ago and is really excited. I actually thought it might have started already since he had said something about the end of the year.

                  Interestingly enough, he had said that if Dad doesn't seem to respond to Keytruda alone, this might be a possibility for him. I haven't seen any of the selection criteria, and Dr. Algazi might not have either at that point, but it would be interesting if they accepted people who might have had at least a partial response on Keytruda. It does seem like participants would need to be PD-L1 positive from what the article says. 

                  I'll be seeing Dr. Algazi in a few hours, so I'll try to remember to ask him about this. 

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