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If High Dose Interferon (HD IFN) is your only choice offered to you.. Then what?
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If High Dose Interferon (HD IFN) is your only choice offered to you.. Then what?

› Forums › General Melanoma Community › If High Dose Interferon (HD IFN) is your only choice offered to you.. Then what?

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    • March 29, 2011 at 5:27 pm
    jim Breitfeller
    Participant

      IF you are offered "wait and see" or HD interferon, you may want to do HD  interferon for 29 days and then get tested for phosphorylated STAT1 (pSTAT1) .

      IF you are offered "wait and see" or HD interferon, you may want to do HD  interferon for 29 days and then get tested for phosphorylated STAT1 (pSTAT1) .

       Stat1 signaling helps differentiates the Naïve T-cells toward the TH1 phenotype needed to attack the Tumor cells.
       
      High pSTAT1 in peripheral blood Tcells of Melanoma Patients may correlate with good clinical outcome in the first 29 days of HD IFN therapy.
       

      TH1 adaptive immunity, and immunosuppression suggested that TH1 adaptive immunity has a beneficial effect on clinical outcome.

      Bets regards,

       

      Jimmy B

       

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