I have been offered an Anti PD 1 trial if I advance: need info

http://news.yahoo.com/bristol-immune-drug-shows-promise-three-cancers-040607286–finance.html?utm_source=twitterfeed&utm_medium=twitter

This doesn't explain it too much other than saying it takes the brakes off the immune system. Cancer is applying the brakes to protect itself. I just had the last of my second series of anti-PD1 infusions and will be going on 3-month mainentance treatments. I'll have a CT & MRI next week to see if its still working for me. My onc is very optimistic.   Dan

http://news.yahoo.com/bristol-immune-drug-shows-promise-three-cancers-040607286–finance.html?utm_source=twitterfeed&utm_medium=twitter

This doesn't explain it too much other than saying it takes the brakes off the immune system. Cancer is applying the brakes to protect itself. I just had the last of my second series of anti-PD1 infusions and will be going on 3-month mainentance treatments. I'll have a CT & MRI next week to see if its still working for me. My onc is very optimistic.   Dan

http://news.yahoo.com/bristol-immune-drug-shows-promise-three-cancers-040607286–finance.html?utm_source=twitterfeed&utm_medium=twitter

This doesn't explain it too much other than saying it takes the brakes off the immune system. Cancer is applying the brakes to protect itself. I just had the last of my second series of anti-PD1 infusions and will be going on 3-month mainentance treatments. I'll have a CT & MRI next week to see if its still working for me. My onc is very optimistic.   Dan

This might be a good trial for you to consider. Hope this explanation helps:

PD-1 is a molecule found on the surface of immune cells. There's some laboratory evidence that suggests this molecule may suppress immune responses against cancer. If you can block it, it may enhance anti-tumor immunity and shrink tumors.

Do a search in the forum. There are a number of people doing really well on this trial.

This might be a good trial for you to consider. Hope this explanation helps:

PD-1 is a molecule found on the surface of immune cells. There's some laboratory evidence that suggests this molecule may suppress immune responses against cancer. If you can block it, it may enhance anti-tumor immunity and shrink tumors.

Do a search in the forum. There are a number of people doing really well on this trial.

This might be a good trial for you to consider. Hope this explanation helps:

PD-1 is a molecule found on the surface of immune cells. There's some laboratory evidence that suggests this molecule may suppress immune responses against cancer. If you can block it, it may enhance anti-tumor immunity and shrink tumors.

Do a search in the forum. There are a number of people doing really well on this trial.

Terri:

I will try to explain it a bit.

PD-1 stands for Programmed Death-1, and is the name of a membrane protein.  In other words, it sits on the membrane of a cell.    It is engaged or activated by its counterpart PDL-1.  PDL-1 is Programmed Death Ligand 1, and is a trans-membrane protein.  In other words, it goes through the cell membrane.

When PDL-1 engages PD-1 a lot of things happen to regulate or inactivate the immune system.  It stops the formation of T-cells, which are critical in attacking unhealthy cells like cancer.  It also stops some of the formation of IL-2.

At least four companies are working on drugs that stop this from happening.  Some block the function of PD-1, and some block the function of PDL-1.  

You may have heard of Yervoy, or ipi.  This drug was approved last March, and was the first new drug approved for melanoma in 13 years.  Yervoy blocks the function of a protein called CTLA-4.  PD-1 is in the same class or family as CTLA-4, so these anti-PD1 drugs work in a very similar fashion.  So far, only limited studies have been done with PD-1 drugs, but the early data is promising.  It appears that at least some of these drugs work better than Yervoy, and with fewer side effects.  Only time will tell if this is the case, but the melanoma doctors I know are very excited about these drugs.

Hope this helps.

Tim–MRF

Terri:

I will try to explain it a bit.

PD-1 stands for Programmed Death-1, and is the name of a membrane protein.  In other words, it sits on the membrane of a cell.    It is engaged or activated by its counterpart PDL-1.  PDL-1 is Programmed Death Ligand 1, and is a trans-membrane protein.  In other words, it goes through the cell membrane.

When PDL-1 engages PD-1 a lot of things happen to regulate or inactivate the immune system.  It stops the formation of T-cells, which are critical in attacking unhealthy cells like cancer.  It also stops some of the formation of IL-2.

At least four companies are working on drugs that stop this from happening.  Some block the function of PD-1, and some block the function of PDL-1.  

You may have heard of Yervoy, or ipi.  This drug was approved last March, and was the first new drug approved for melanoma in 13 years.  Yervoy blocks the function of a protein called CTLA-4.  PD-1 is in the same class or family as CTLA-4, so these anti-PD1 drugs work in a very similar fashion.  So far, only limited studies have been done with PD-1 drugs, but the early data is promising.  It appears that at least some of these drugs work better than Yervoy, and with fewer side effects.  Only time will tell if this is the case, but the melanoma doctors I know are very excited about these drugs.

Hope this helps.

Tim–MRF

Terri:

I will try to explain it a bit.

PD-1 stands for Programmed Death-1, and is the name of a membrane protein.  In other words, it sits on the membrane of a cell.    It is engaged or activated by its counterpart PDL-1.  PDL-1 is Programmed Death Ligand 1, and is a trans-membrane protein.  In other words, it goes through the cell membrane.

When PDL-1 engages PD-1 a lot of things happen to regulate or inactivate the immune system.  It stops the formation of T-cells, which are critical in attacking unhealthy cells like cancer.  It also stops some of the formation of IL-2.

At least four companies are working on drugs that stop this from happening.  Some block the function of PD-1, and some block the function of PDL-1.  

You may have heard of Yervoy, or ipi.  This drug was approved last March, and was the first new drug approved for melanoma in 13 years.  Yervoy blocks the function of a protein called CTLA-4.  PD-1 is in the same class or family as CTLA-4, so these anti-PD1 drugs work in a very similar fashion.  So far, only limited studies have been done with PD-1 drugs, but the early data is promising.  It appears that at least some of these drugs work better than Yervoy, and with fewer side effects.  Only time will tell if this is the case, but the melanoma doctors I know are very excited about these drugs.

Hope this helps.

Tim–MRF

I contacted Dr Weber regarding a person in Spain looking for a Anti-PD-1 trial. He said they have slots open at Moffit in the sister trial of mine using BMS's Anti-PD-1. They are accepting people who have used Yervoy …aka Ipi and progressed..

I contacted Dr Weber regarding a person in Spain looking for a Anti-PD-1 trial. He said they have slots open at Moffit in the sister trial of mine using BMS's Anti-PD-1. They are accepting people who have used Yervoy …aka Ipi and progressed..

I contacted Dr Weber regarding a person in Spain looking for a Anti-PD-1 trial. He said they have slots open at Moffit in the sister trial of mine using BMS's Anti-PD-1. They are accepting people who have used Yervoy …aka Ipi and progressed..