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How long does it take for ipi to usually work?

Forums General Melanoma Community How long does it take for ipi to usually work?

  • Post
    adgesoph
    Participant

    My dad is being discharged from Vandy because they say there are no more trials for him there anymore.  Needless to say I'm pissed but he's going to try ipi at UVA, closer to where he lives.  He's getting gamma knife at Nashville for his 3 brain mets and then will return home.  He also has 2 lung mets, 2 tumors on the back of his neck (very painful) and a tumor in his pelvis.   However I guess they feel his disease is pretty aggressive, after not responding the the braf brain met trial.  I just hope ipi can start working in time.

    My dad is being discharged from Vandy because they say there are no more trials for him there anymore.  Needless to say I'm pissed but he's going to try ipi at UVA, closer to where he lives.  He's getting gamma knife at Nashville for his 3 brain mets and then will return home.  He also has 2 lung mets, 2 tumors on the back of his neck (very painful) and a tumor in his pelvis.   However I guess they feel his disease is pretty aggressive, after not responding the the braf brain met trial.  I just hope ipi can start working in time.  Not sure if he has 12 weeks, according to these doctors.  Anyone had a faster response?

     

    Adrienne

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      ValinMtl
      Participant

      Hi Adrienne

      It's really hard to say how quickly ipilimumab can work.  My first time round in September, I had 100s of cutaneous lesions on right leg and after the very first treatment I could see change…they stopped increasing (thank goodness) plus some started drying up immediately.  Unfortunately, I had recurrence with several sub-qs on right leg  and a renegade lymph node in my left groin (size of golf ball right now).  I have had my second treatment since March and I see no change whatsoever so worry time.  

      People do react differently to ipilimumab (keeping in mind if they respond)…some almost immediately, some a few treatments in.  I pray your father responds as quickly as possible.  I'm sure others will respond with their thoughts or look at the 'rollcall on ipi' by Douglas (killmel) not too far down on the page.

       

      Val

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      ValinMtl
      Participant

      Hi Adrienne

      It's really hard to say how quickly ipilimumab can work.  My first time round in September, I had 100s of cutaneous lesions on right leg and after the very first treatment I could see change…they stopped increasing (thank goodness) plus some started drying up immediately.  Unfortunately, I had recurrence with several sub-qs on right leg  and a renegade lymph node in my left groin (size of golf ball right now).  I have had my second treatment since March and I see no change whatsoever so worry time.  

      People do react differently to ipilimumab (keeping in mind if they respond)…some almost immediately, some a few treatments in.  I pray your father responds as quickly as possible.  I'm sure others will respond with their thoughts or look at the 'rollcall on ipi' by Douglas (killmel) not too far down on the page.

       

      Val

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      Gene_S
      Participant

      Hello Adrienne,

      Keep in mind that ippi works only in 1 of 6 patients accordingly to my oncologist.

      My SUGGESTION would be to do some homework on the experimental drug PLX4032.

      It could possibly buy your dad some time to find another type of treatment ?

      see:  http://www.reuters.com/article/2010/08/25/cancer-melanoma-roche-idUSN2515101020100825

      If he does start ippi, and has bad reactions, stop the treatment asap as ippi does have very severe side effects depending on the person receiving the treatment.

      Best wishes,

      Gene

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      Gene_S
      Participant

      Hello Adrienne,

      Keep in mind that ippi works only in 1 of 6 patients accordingly to my oncologist.

      My SUGGESTION would be to do some homework on the experimental drug PLX4032.

      It could possibly buy your dad some time to find another type of treatment ?

      see:  http://www.reuters.com/article/2010/08/25/cancer-melanoma-roche-idUSN2515101020100825

      If he does start ippi, and has bad reactions, stop the treatment asap as ippi does have very severe side effects depending on the person receiving the treatment.

      Best wishes,

      Gene

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        adgesoph
        Participant

        Thank you for your responses.  My dad has failed the braf brain met trial at Vanderbilt so I don't think PLX would work for him.  He's got to get the brain mets resolved to get into another trial any way and we don't think there is a lot of time.  He may still not meet the parameters of the trials with his declining health.  Ipi is really the only thing we can start taking quickly but I know it may not even work and if it does it may be too late.  But we have to try. Where would he get ipi or yervoy from.  Just an oncologist?

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        amberhulin
        Participant

        Adrienne,

        My father was in a similar situation with exception of brain mets. After one treatment of ipi his tumors got hard and some began to get smaller. His body was so weak he was unable to complete the clinical trial, still we all felt the ipi was working. He previously failed IL-2 as well. We got into the clinical trail through a referral from our oncologist so you can always start there.

        Good luck,

        Amber

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        amberhulin
        Participant

        Adrienne,

        My father was in a similar situation with exception of brain mets. After one treatment of ipi his tumors got hard and some began to get smaller. His body was so weak he was unable to complete the clinical trial, still we all felt the ipi was working. He previously failed IL-2 as well. We got into the clinical trail through a referral from our oncologist so you can always start there.

        Good luck,

        Amber

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        Gene_S
        Participant

        Here is a website that may help you.

        see: http://www.collabrx.com/

        Best wishes,

        Gene

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        Gene_S
        Participant

        Here is a website that may help you.

        see: http://www.collabrx.com/

        Best wishes,

        Gene

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        adgesoph
        Participant

        Thank you for your responses.  My dad has failed the braf brain met trial at Vanderbilt so I don't think PLX would work for him.  He's got to get the brain mets resolved to get into another trial any way and we don't think there is a lot of time.  He may still not meet the parameters of the trials with his declining health.  Ipi is really the only thing we can start taking quickly but I know it may not even work and if it does it may be too late.  But we have to try. Where would he get ipi or yervoy from.  Just an oncologist?

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      James from Sydney
      Participant

      Ask about the new drug E7080 see the post below from "vickrs" it appears that it can give a quick response.

      best wishes

      James

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      James from Sydney
      Participant

      Ask about the new drug E7080 see the post below from "vickrs" it appears that it can give a quick response.

      best wishes

      James

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