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HLA_A2 exclusion/inclusion
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HLA_A2 exclusion/inclusion

› Forums › General Melanoma Community › HLA_A2 exclusion/inclusion

  • Post
    • March 6, 2012 at 5:49 pm
    jim Breitfeller
    Participant

      Boots,

      HLA_A2 exclusion/inclusion  is 

      Boots,

      HLA_A2 exclusion/inclusion  is 

      The human leukocyte antigen (HLA) test, also known as HLA typing or tissue typing, identifies antigens on the white blood cells (WBCs) T-cells  that determine tissue compatibility.The  peptide-based vaccines are produced with HLA-02 petides/ antigens. So to be able to benefit from this type of therapy, your T-cells must have HLA-02 type.  are produced from

       

      Jimmy B

    Viewing 2 reply threads
    • Replies
        • March 6, 2012 at 7:08 pm
        boot2aboot
        Participant

          who decided that qualifier? Rosenberg at NIH. and, who carries that genotype? northern europians mostly…i feel MOST discriminated against..FOUL!

            • March 6, 2012 at 7:32 pm
            jim Breitfeller
            Participant

              A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotype, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206. 

               

              Jimmy b

              • March 27, 2012 at 7:51 am
              LynnLuc
              Participant

                For my anti pd-1/peptides I had to have

                • HLA-A*0201-positive 
                • Positive staining of the most recently resected tumor tissue with antibodies to ≥ 1 of the following: HMB 45 for gp 100, NY-ESO-1, and/or MART-1

                I had all but the NY ESO-1   LynnL

                • March 27, 2012 at 7:51 am
                LynnLuc
                Participant

                  For my anti pd-1/peptides I had to have

                  • HLA-A*0201-positive 
                  • Positive staining of the most recently resected tumor tissue with antibodies to ≥ 1 of the following: HMB 45 for gp 100, NY-ESO-1, and/or MART-1

                  I had all but the NY ESO-1   LynnL

                  • March 27, 2012 at 7:51 am
                  LynnLuc
                  Participant

                    For my anti pd-1/peptides I had to have

                    • HLA-A*0201-positive 
                    • Positive staining of the most recently resected tumor tissue with antibodies to ≥ 1 of the following: HMB 45 for gp 100, NY-ESO-1, and/or MART-1

                    I had all but the NY ESO-1   LynnL

                    • March 6, 2012 at 7:32 pm
                    jim Breitfeller
                    Participant

                      A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotype, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206. 

                       

                      Jimmy b

                      • March 6, 2012 at 7:32 pm
                      jim Breitfeller
                      Participant

                        A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotype, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206. 

                         

                        Jimmy b

                      • March 6, 2012 at 7:08 pm
                      boot2aboot
                      Participant

                        who decided that qualifier? Rosenberg at NIH. and, who carries that genotype? northern europians mostly…i feel MOST discriminated against..FOUL!

                        • March 6, 2012 at 7:08 pm
                        boot2aboot
                        Participant

                          who decided that qualifier? Rosenberg at NIH. and, who carries that genotype? northern europians mostly…i feel MOST discriminated against..FOUL!

                      Viewing 2 reply threads
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