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HLA_A2 exclusion/inclusion

Forums General Melanoma Community HLA_A2 exclusion/inclusion

  • Post
    jim Breitfeller
    Participant

      Boots,

      HLA_A2 exclusion/inclusion  is 

      Boots,

      HLA_A2 exclusion/inclusion  is 

      The human leukocyte antigen (HLA) test, also known as HLA typing or tissue typing, identifies antigens on the white blood cells (WBCs) T-cells  that determine tissue compatibility.The  peptide-based vaccines are produced with HLA-02 petides/ antigens. So to be able to benefit from this type of therapy, your T-cells must have HLA-02 type.  are produced from

       

      Jimmy B

    Viewing 2 reply threads
    • Replies
        boot2aboot
        Participant

          who decided that qualifier? Rosenberg at NIH. and, who carries that genotype? northern europians mostly…i feel MOST discriminated against..FOUL!

            jim Breitfeller
            Participant

              A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotype, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206. 

               

              Jimmy b

              LynnLuc
              Participant

                For my anti pd-1/peptides I had to have

                • HLA-A*0201-positive 
                • Positive staining of the most recently resected tumor tissue with antibodies to ≥ 1 of the following: HMB 45 for gp 100, NY-ESO-1, and/or MART-1

                I had all but the NY ESO-1   LynnL

                LynnLuc
                Participant

                  For my anti pd-1/peptides I had to have

                  • HLA-A*0201-positive 
                  • Positive staining of the most recently resected tumor tissue with antibodies to ≥ 1 of the following: HMB 45 for gp 100, NY-ESO-1, and/or MART-1

                  I had all but the NY ESO-1   LynnL

                  LynnLuc
                  Participant

                    For my anti pd-1/peptides I had to have

                    • HLA-A*0201-positive 
                    • Positive staining of the most recently resected tumor tissue with antibodies to ≥ 1 of the following: HMB 45 for gp 100, NY-ESO-1, and/or MART-1

                    I had all but the NY ESO-1   LynnL

                    jim Breitfeller
                    Participant

                      A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotype, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206. 

                       

                      Jimmy b

                      jim Breitfeller
                      Participant

                        A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotype, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206. 

                         

                        Jimmy b

                      boot2aboot
                      Participant

                        who decided that qualifier? Rosenberg at NIH. and, who carries that genotype? northern europians mostly…i feel MOST discriminated against..FOUL!

                        boot2aboot
                        Participant

                          who decided that qualifier? Rosenberg at NIH. and, who carries that genotype? northern europians mostly…i feel MOST discriminated against..FOUL!

                      Viewing 2 reply threads
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