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GSK BRAF with randomized MEK trial—then what?

Forums General Melanoma Community GSK BRAF with randomized MEK trial—then what?

  • Post
    mommydog
    Participant

    My husband has been on this trial at UCSF for 26 weeks now.  His tumors have been reduced by over 74% and have gone from a total of over 15 cm to slightly over 3 cm.  He has had 3 PET scans, and there has been improvement each time, although it has been less dramatic each time.

    My husband has been on this trial at UCSF for 26 weeks now.  His tumors have been reduced by over 74% and have gone from a total of over 15 cm to slightly over 3 cm.  He has had 3 PET scans, and there has been improvement each time, although it has been less dramatic each time.

    Although I am thrilled, I am concerned about all of the comments that this treatment causes only temporary results.  What is the plan b?  When do we know that it is time to pursue another course of action?  Is the BRAF/MEK treatment always just temporary?  Since 77% of the patients from the Roche trials are still living, how do we know this to be true?

    Thanks for any insite or advice.

    Deborah

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  • Replies
      Charlie S
      Participant

      Try not to overthink a possible problem of tomorrow to the point of distraction of today.

      Yes, there is some concern about  durability, but I have learned it is a question of the ability of today with not only melanoma but life in general..

      To ease your concerns, have an open conversationn with his doc and ask if their is a plan forward should there be a setback.

      Other than a bunch of numbers, do you have any physical reason to think he will not be a responder?   Nothing is true with melanomna..

      My suggestion?  Unannounced, ,drag your husband out to some notelll motel for a few hours of  less than holy activity and  afford yourselves a fun day…………..after all, is it not  the day with him you desire?

      At least you will have a distraction and can check one another for bedbugs.

      Cheers,

      Charlie S

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      Charlie S
      Participant

      Try not to overthink a possible problem of tomorrow to the point of distraction of today.

      Yes, there is some concern about  durability, but I have learned it is a question of the ability of today with not only melanoma but life in general..

      To ease your concerns, have an open conversationn with his doc and ask if their is a plan forward should there be a setback.

      Other than a bunch of numbers, do you have any physical reason to think he will not be a responder?   Nothing is true with melanomna..

      My suggestion?  Unannounced, ,drag your husband out to some notelll motel for a few hours of  less than holy activity and  afford yourselves a fun day…………..after all, is it not  the day with him you desire?

      At least you will have a distraction and can check one another for bedbugs.

      Cheers,

      Charlie S

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