Melanoma Peeps! Just received good scan results after 8 cycles (started in January) of intralesional injections + Pembro. Two of the four head and neck tumors have been injected with IL-12 and tavokinogene telseplasmid (?) and received electroporation every 6 weeks, and I’ve had Pembro infusions every three weeks. The target and by-stander lesions on my scalp, both palpable, are gone. Here’s the scan report for the target lesion and bystander lesions on my neck, both decreasing:
- July 19, 2019 at 1:11 am
– Right level 5A node: 0.9 cm in short axis (series 502, image 129), previously 1.1 cm. Current SUV max 9.29, previously 12.8.
– Right level 2B/3 node: 4 mm (series 502, image 152), previously 9 mm. Current SUV max 5.3, previously 9.3.
Trial info: https://immuno-oncologynews.com/2018/11/30/tavo-reverses-resistance-pd-1-inhibitors-metastatic-melanoma-phase-2b-trial/
I’m cautiously optimistic. Hoping this post can help someone else.
MelanomaMikeParticipantIkb!!! Thats such AWESOME NEWS! im right behind ya “hopefilly” with treatments like that, PV10, IL12, TVEC bring it! You read my latest posts im trying to ditch Kaiser and see Dr Hamid at The Angeles Clinical…clinical trials what ever! But intralesional weapons are a God send!! “TIL” even!…im so happy for you, gives me Hope!!! Love ya ikb…
- July 19, 2019 at 5:04 am
sister of patientParticipantLove it!!! Great job – kicking mel’s ass to the curb – go, go, go!!!!!
- July 19, 2019 at 5:30 pm
jbronickiParticipantWonderful! Just read this as we just got back from vacation for last week. This is the type of updates we love to hear, congrats!
- July 22, 2019 at 3:52 am
- July 22, 2019 at 1:11 pm
Am glad for you and your good news. I took pembro + TVEC for one year, after pembro alone failed to achieve any reduction. After growing while on treatment (it reached about 3.5cm on ultrasound, less than this on the MRI) after about six weeks the tumour stopped growing and started to shrink. I could see the (nervewrackingly slow) progress every two weeks on ultrasound. After one year it shrank to 1.5cm but with width of only 0.2cm so was very hard to detect. Five months ago, I was NED; then two months ago it came back but at 0.2cm and it could be scar tissue.
I asked my oncologist about the results. I was the first in my hospital to try this treatment and wondered if it was a miracle cure, it seemed so good. They tried it on others with a (much?) greater tumour burden and for them it was not successful.
I think intralesional combined with pembro is a great approach. I am a little scared because I never quite make it to NED and life hangs on a thread and I dont want to jinx anything, but I think its a great approach and would encourage others to try it, especially if light tumour burden. my doctors were surprised insurance approved this combo (even though it makes a lot of sense i dont think its standard of care) and when insurance did approve they had to kind of scramble to deliver it (i had to change hospital and doctor). texmelanomex has done will with rose bengal plus pembro, so it would be good to get more data points to see how good this is. in my case it was a big deal because i had been on pembro on and off for more than one year with stable disease / slight progression, so adding tvec made a big difference. still I dont want to jinx it.
good luck Mark
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