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Good news with Yervoy

Forums General Melanoma Community Good news with Yervoy

  • Post
    Marianne quinn
    Participant

      My husband was diagnosed at Stage 3C in September 2013. He had melanoma under his thumbnail which he dd not investigate for at least 1 year. After a partial amputation and lymphendectomy, he was NED  and entered the clinical trial of yervoy vs interferon trial.. He was in the 10 mg arm ( there was also a 3 mg arm). We were very nervous about the high dose and the side effects. With diet modification and occassional use of OTC medication, he weathered GI effects without needing steroids. To our dismay in March, his CAT scan after the induction phase of 4 infusions showed a small metastasis in his liver. He was removed from the trial. We were absolutely devastated thinking the ipi did not work. In May2014, he had microwave ablation of the single metastasis. We were pleased to find out that at the time of surgery, the metastasis was slightly smaller than the CAT scan indicated 6 weeks before.He became NED.

      Monday his CAT scan was clear. Thinking how it was last March, I am so grateful and appreciative of this forum that kep me informed and positive. We are sure that the Yervoy worked and he just had what is termed as a "unconventional" response.  

      I know that people are scared of Yervoy, but it can work. It seems unfair that you have to "fail" Yervoy before you get the anti-PD1s. However, Yervoy might work for you. Even if you "fail" it, maybe getting the anti- PD1 afterwards might be more effective after having the Yervoy. Just speculating, but the medications work in different ways so who really knows? 

      Just for interest, he had his last dose of ipi in March 2014. He still has a sensitive GI tract, but only to whole wheat and milk. He can drink lactaid.  He makes a smoothie of bananas, applesauce, and Greek yogurt with active cultures daily. He believes that repopulating his GI tract with beneficial bacteria helped keep the diarrhea under control. We think he has a permanent change to his immune system which is the goal of therapy. Hope we are right.

      Best of luck to you all. 

    Viewing 11 reply threads
    • Replies
        Maureen038
        Participant

          I hope your husband continues to be NED! Congratulations!!

          Maureen

          Maureen038
          Participant

            I hope your husband continues to be NED! Congratulations!!

            Maureen

            Maureen038
            Participant

              I hope your husband continues to be NED! Congratulations!!

              Maureen

              Mom2Addy
              Participant

                Dose #2 for my husband yesterday and we are hopeful after brain and body mets. SRS in January, surgery to remove 4 rumors in Feb now Yervoy. Staying positive (but it's hard). I am so glad I logged on tonight, this is the second good news story and its renewed my faith! Fight the good fight! 

                  yazziemac
                  Participant

                    Thanks so much, I needed to hear this today!  My husband had Yervoy infusion #1 yesterday and has mets all over the place.  It would be wonderful if the Yervoy works for my husband too!

                    Yasmin

                    yazziemac
                    Participant

                      Thanks so much, I needed to hear this today!  My husband had Yervoy infusion #1 yesterday and has mets all over the place.  It would be wonderful if the Yervoy works for my husband too!

                      Yasmin

                      yazziemac
                      Participant

                        Thanks so much, I needed to hear this today!  My husband had Yervoy infusion #1 yesterday and has mets all over the place.  It would be wonderful if the Yervoy works for my husband too!

                        Yasmin

                      Mom2Addy
                      Participant

                        Dose #2 for my husband yesterday and we are hopeful after brain and body mets. SRS in January, surgery to remove 4 rumors in Feb now Yervoy. Staying positive (but it's hard). I am so glad I logged on tonight, this is the second good news story and its renewed my faith! Fight the good fight! 

                        Mom2Addy
                        Participant

                          Dose #2 for my husband yesterday and we are hopeful after brain and body mets. SRS in January, surgery to remove 4 rumors in Feb now Yervoy. Staying positive (but it's hard). I am so glad I logged on tonight, this is the second good news story and its renewed my faith! Fight the good fight! 

                          _Paul_
                          Participant

                            As someone who has "failed" Yervoy and has now moved on to Keytruda, I love hearing these reports! Thank you very much for posting and congatulations on your husband's NEDness!

                            _Paul_
                            Participant

                              As someone who has "failed" Yervoy and has now moved on to Keytruda, I love hearing these reports! Thank you very much for posting and congatulations on your husband's NEDness!

                              _Paul_
                              Participant

                                As someone who has "failed" Yervoy and has now moved on to Keytruda, I love hearing these reports! Thank you very much for posting and congatulations on your husband's NEDness!

                                Jubes
                                Participant

                                  Yes I 'failed' yervoy too. But glad it's in my system anyway. Doing well on keytruda and so grateful for all these positive stories

                                  Jubes
                                  Participant

                                    Yes I 'failed' yervoy too. But glad it's in my system anyway. Doing well on keytruda and so grateful for all these positive stories

                                    Jubes
                                    Participant

                                      Yes I 'failed' yervoy too. But glad it's in my system anyway. Doing well on keytruda and so grateful for all these positive stories

                                  Viewing 11 reply threads
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