› Forums › General Melanoma Community › genetic and molecular types of melanoma?
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Annalive.
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- August 13, 2014 at 3:01 pm
Cancer should be classified by genetic and molecular types, say scientists
Just wondering what the proposal in this article would mean for melanoma? Other than BRAF and CKit, what would the types be?
If anyone knows something I could read to find out, please let me know.
Thanks –
Hazel
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- August 13, 2014 at 5:20 pm
Hi Hazel,
My husband had the 50-Gene Somatic Mutation Analysis Panel done on his tumor. If you remember, he has a similar case where they can't rule out metastatic melanoma since there is no intraepidermal component (some have said primary dermal melanoma but our oncologist at MD Anderson won't say that). He had 19 mm melanoma removed from back but scans to date have shown NED and he is not doing any treatments. He was found to have NRAS mutation in his. Here is an image from the genetic mutation test from MD Anderson. Looks like BRAF, KIT, and NRAS are what they look for in Melanoma (I beleive NRAS is found less frequently than BRAF):
50-Gene Somatic Mutation Analysis Panel Report**:
Clinical test requisition for mutation studies on the following genes was received: BRAF, KIT, NRAS
A next generation sequencing (NGS)-based analysis for the detection of somatic mutations in the coding sequence of a total of 50 genes
was performed on the DNA extracted from the sample in our CLIA-certified molecular diagnostics laboratory. Interpretative findings are
reported in the mutation screening summary table(s) below followed by specific details of detected variants.Interpretation Key:
Circled/Bold: Mutation (or variant) detected
Underlined: Mutation testing requested (ordered gene)
Asterisk: Additional confirmation studies in progress, addendum report will be issuedMUTATION SCREENING SUMMARY:
ABL1 CSF1R FGFR2 IDH1 MLH1 PTPN11 TP53
AKT1 CTNNB1 FGFR3 IDH2 MPL RB1 VHL
ALK EGFR FLT3 JAK2 NOTCH1 RET
APC ERBB2 GNA11 JAK3 NPM1 SMAD4
ATM ERBB4 GNAQ KDR NRAS SMARCB1
BRAF EZH2 GNAS KIT PDGFRA SMO
CDH1 FBXW7 HNF1A KRAS PIK3CA SRC
CDKN2A FGFR1 HRAS MET PTEN STK11I. Mutations in ordered genes
Gene Standardized Nomenclature (HGVS) Location DNA change Protein change dbSNP ID COSMIC
ID
NRAS NM_002524.4(NRAS):c.181C>A p.Q61K Exon 3 SNV Missense rs121913254COSM580 -
- August 13, 2014 at 5:20 pm
Hi Hazel,
My husband had the 50-Gene Somatic Mutation Analysis Panel done on his tumor. If you remember, he has a similar case where they can't rule out metastatic melanoma since there is no intraepidermal component (some have said primary dermal melanoma but our oncologist at MD Anderson won't say that). He had 19 mm melanoma removed from back but scans to date have shown NED and he is not doing any treatments. He was found to have NRAS mutation in his. Here is an image from the genetic mutation test from MD Anderson. Looks like BRAF, KIT, and NRAS are what they look for in Melanoma (I beleive NRAS is found less frequently than BRAF):
50-Gene Somatic Mutation Analysis Panel Report**:
Clinical test requisition for mutation studies on the following genes was received: BRAF, KIT, NRAS
A next generation sequencing (NGS)-based analysis for the detection of somatic mutations in the coding sequence of a total of 50 genes
was performed on the DNA extracted from the sample in our CLIA-certified molecular diagnostics laboratory. Interpretative findings are
reported in the mutation screening summary table(s) below followed by specific details of detected variants.Interpretation Key:
Circled/Bold: Mutation (or variant) detected
Underlined: Mutation testing requested (ordered gene)
Asterisk: Additional confirmation studies in progress, addendum report will be issuedMUTATION SCREENING SUMMARY:
ABL1 CSF1R FGFR2 IDH1 MLH1 PTPN11 TP53
AKT1 CTNNB1 FGFR3 IDH2 MPL RB1 VHL
ALK EGFR FLT3 JAK2 NOTCH1 RET
APC ERBB2 GNA11 JAK3 NPM1 SMAD4
ATM ERBB4 GNAQ KDR NRAS SMARCB1
BRAF EZH2 GNAS KIT PDGFRA SMO
CDH1 FBXW7 HNF1A KRAS PIK3CA SRC
CDKN2A FGFR1 HRAS MET PTEN STK11I. Mutations in ordered genes
Gene Standardized Nomenclature (HGVS) Location DNA change Protein change dbSNP ID COSMIC
ID
NRAS NM_002524.4(NRAS):c.181C>A p.Q61K Exon 3 SNV Missense rs121913254COSM580 -
- August 13, 2014 at 5:20 pm
Hi Hazel,
My husband had the 50-Gene Somatic Mutation Analysis Panel done on his tumor. If you remember, he has a similar case where they can't rule out metastatic melanoma since there is no intraepidermal component (some have said primary dermal melanoma but our oncologist at MD Anderson won't say that). He had 19 mm melanoma removed from back but scans to date have shown NED and he is not doing any treatments. He was found to have NRAS mutation in his. Here is an image from the genetic mutation test from MD Anderson. Looks like BRAF, KIT, and NRAS are what they look for in Melanoma (I beleive NRAS is found less frequently than BRAF):
50-Gene Somatic Mutation Analysis Panel Report**:
Clinical test requisition for mutation studies on the following genes was received: BRAF, KIT, NRAS
A next generation sequencing (NGS)-based analysis for the detection of somatic mutations in the coding sequence of a total of 50 genes
was performed on the DNA extracted from the sample in our CLIA-certified molecular diagnostics laboratory. Interpretative findings are
reported in the mutation screening summary table(s) below followed by specific details of detected variants.Interpretation Key:
Circled/Bold: Mutation (or variant) detected
Underlined: Mutation testing requested (ordered gene)
Asterisk: Additional confirmation studies in progress, addendum report will be issuedMUTATION SCREENING SUMMARY:
ABL1 CSF1R FGFR2 IDH1 MLH1 PTPN11 TP53
AKT1 CTNNB1 FGFR3 IDH2 MPL RB1 VHL
ALK EGFR FLT3 JAK2 NOTCH1 RET
APC ERBB2 GNA11 JAK3 NPM1 SMAD4
ATM ERBB4 GNAQ KDR NRAS SMARCB1
BRAF EZH2 GNAS KIT PDGFRA SMO
CDH1 FBXW7 HNF1A KRAS PIK3CA SRC
CDKN2A FGFR1 HRAS MET PTEN STK11I. Mutations in ordered genes
Gene Standardized Nomenclature (HGVS) Location DNA change Protein change dbSNP ID COSMIC
ID
NRAS NM_002524.4(NRAS):c.181C>A p.Q61K Exon 3 SNV Missense rs121913254COSM580 -
- August 18, 2014 at 1:40 pm
I have been trying for a long time to get an answer to this. Wild type mutations make up about 28% of the mutations. Among that 28%, are the wild types a singular muations, or are they a combination of "none of the above"?
Can anyone clarify this.
Thanks.
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- August 18, 2014 at 5:14 pm
I believe wild tyoe means the gene most commonly in the population, i.e. the unmutayed version. That would mean the unmutated v600 braf gene is wild type for that gene.whereas for NRAS G12a my tumors' versions of that gene have been mutated, so they are not wild type for nras g12.that could be right or wrong! -
- August 18, 2014 at 5:14 pm
I believe wild tyoe means the gene most commonly in the population, i.e. the unmutayed version. That would mean the unmutated v600 braf gene is wild type for that gene.whereas for NRAS G12a my tumors' versions of that gene have been mutated, so they are not wild type for nras g12.that could be right or wrong! -
- August 18, 2014 at 5:14 pm
I believe wild tyoe means the gene most commonly in the population, i.e. the unmutayed version. That would mean the unmutated v600 braf gene is wild type for that gene.whereas for NRAS G12a my tumors' versions of that gene have been mutated, so they are not wild type for nras g12.that could be right or wrong! -
- August 18, 2014 at 1:40 pm
I have been trying for a long time to get an answer to this. Wild type mutations make up about 28% of the mutations. Among that 28%, are the wild types a singular muations, or are they a combination of "none of the above"?
Can anyone clarify this.
Thanks.
-
- August 18, 2014 at 1:40 pm
I have been trying for a long time to get an answer to this. Wild type mutations make up about 28% of the mutations. Among that 28%, are the wild types a singular muations, or are they a combination of "none of the above"?
Can anyone clarify this.
Thanks.
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Tagged: cutaneous melanoma
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