Failed IPI, PD-1, and Dabrafenib/Keytruda. Spine tumor. Any trials to keep my eye on?

Sorry you aren't having success with your treatments so far.  The below thread was posted a month or two ago and may be a good starting point for some ideas.  Another option may be the NCI-Match Clinical trial. 

https://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/trials-joshieand-othersin-one

Sorry you aren't having success with your treatments so far.  The below thread was posted a month or two ago and may be a good starting point for some ideas.  Another option may be the NCI-Match Clinical trial. 

https://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/trials-joshieand-othersin-one

Sorry you aren't having success with your treatments so far.  The below thread was posted a month or two ago and may be a good starting point for some ideas.  Another option may be the NCI-Match Clinical trial. 

https://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/trials-joshieand-othersin-one

Hi Anon,

I am in a similar situation as your self. I have tried:

yervoy (with SRS) – partial response but one large tumor unaffected 

keytryda (mono) – stable response for 1.5 years 

atezolizumab + anti-OX-40 – pissed cancer off which spread all over

TIL – low yield and only 3 of 14 bags of IL-2 – may be seeing some small benefit but feels like a mixture of some stability with some growth

Now I am trying to enroll into NCT02302339 which "combines an antibody attached to a cell killing drug, MMAE, which is intended to work by specifically directing the drug to the cancer cell. Glembatumumab vedotin attaches to a molecule called gpNMB that is expressed on the cancer cell and releases the MMAE inside the tumor cell, which in turn causes the cell to die. Varlilumabl is an antibody (a type of human protein) that is manufactured in a laboratory and is being tested to see if it will allow the body's immune system to work against tumor cells."

As I understand it, this trial is for people like ourselves that have failed front line treatments.

I hope this helps you choose your next treatment option. The good news is that there are lots of options available. Working with a knowledge melanoma specialist will help you choose the next path to take.

I am wishing the very best for you – Paul

Hi Anon,

I am in a similar situation as your self. I have tried:

yervoy (with SRS) – partial response but one large tumor unaffected 

keytryda (mono) – stable response for 1.5 years 

atezolizumab + anti-OX-40 – pissed cancer off which spread all over

TIL – low yield and only 3 of 14 bags of IL-2 – may be seeing some small benefit but feels like a mixture of some stability with some growth

Now I am trying to enroll into NCT02302339 which "combines an antibody attached to a cell killing drug, MMAE, which is intended to work by specifically directing the drug to the cancer cell. Glembatumumab vedotin attaches to a molecule called gpNMB that is expressed on the cancer cell and releases the MMAE inside the tumor cell, which in turn causes the cell to die. Varlilumabl is an antibody (a type of human protein) that is manufactured in a laboratory and is being tested to see if it will allow the body's immune system to work against tumor cells."

As I understand it, this trial is for people like ourselves that have failed front line treatments.

I hope this helps you choose your next treatment option. The good news is that there are lots of options available. Working with a knowledge melanoma specialist will help you choose the next path to take.

I am wishing the very best for you – Paul

Hi Anon,

I am in a similar situation as your self. I have tried:

yervoy (with SRS) – partial response but one large tumor unaffected 

keytryda (mono) – stable response for 1.5 years 

atezolizumab + anti-OX-40 – pissed cancer off which spread all over

TIL – low yield and only 3 of 14 bags of IL-2 – may be seeing some small benefit but feels like a mixture of some stability with some growth

Now I am trying to enroll into NCT02302339 which "combines an antibody attached to a cell killing drug, MMAE, which is intended to work by specifically directing the drug to the cancer cell. Glembatumumab vedotin attaches to a molecule called gpNMB that is expressed on the cancer cell and releases the MMAE inside the tumor cell, which in turn causes the cell to die. Varlilumabl is an antibody (a type of human protein) that is manufactured in a laboratory and is being tested to see if it will allow the body's immune system to work against tumor cells."

As I understand it, this trial is for people like ourselves that have failed front line treatments.

I hope this helps you choose your next treatment option. The good news is that there are lots of options available. Working with a knowledge melanoma specialist will help you choose the next path to take.

I am wishing the very best for you – Paul

Hello Anon,

There are plenty of us in the same boat.  Besides some short-lived response to BRAF inhibitors, I have mostly been a non-responder to everything (some limited success with ipi/nivo/radiation combo).  Actually surgery and radiation, direct frontal attacks have been the only truly effective way for me to rid myself of tumors and keep me going 4-years in Stage IV.  Recent surgery was successful in removing all the rest of the known tumors. Otherwise, I was going to begin a trial of Epacadostat & Durvalumab which sounded very promising.  I'll be having my scans next week.  Hope it's all clear, but if not, various trials remain, including TIL/ACT when all the FDA approved options have been eliminated.  You just need to hang in there. Best in the battle.

Gary

Gary

Hello Anon,

There are plenty of us in the same boat.  Besides some short-lived response to BRAF inhibitors, I have mostly been a non-responder to everything (some limited success with ipi/nivo/radiation combo).  Actually surgery and radiation, direct frontal attacks have been the only truly effective way for me to rid myself of tumors and keep me going 4-years in Stage IV.  Recent surgery was successful in removing all the rest of the known tumors. Otherwise, I was going to begin a trial of Epacadostat & Durvalumab which sounded very promising.  I'll be having my scans next week.  Hope it's all clear, but if not, various trials remain, including TIL/ACT when all the FDA approved options have been eliminated.  You just need to hang in there. Best in the battle.

Gary

Gary

Hello Anon,

There are plenty of us in the same boat.  Besides some short-lived response to BRAF inhibitors, I have mostly been a non-responder to everything (some limited success with ipi/nivo/radiation combo).  Actually surgery and radiation, direct frontal attacks have been the only truly effective way for me to rid myself of tumors and keep me going 4-years in Stage IV.  Recent surgery was successful in removing all the rest of the known tumors. Otherwise, I was going to begin a trial of Epacadostat & Durvalumab which sounded very promising.  I'll be having my scans next week.  Hope it's all clear, but if not, various trials remain, including TIL/ACT when all the FDA approved options have been eliminated.  You just need to hang in there. Best in the battle.

Gary

Gary

I failed ipi and pembro individually (and also progressed on BRAF-MEK).  I've had a decent run (12 mos) on ipi-nivo.  While the response rate is lower for patients that have failed individual immunotherapy treatments (like me and you)–there is still a decent response rate.  Other benefits–no need to qualify for a trial, no wash-out period, no travel and no strict rules around steroid use for side effects.  Good luck.

I failed ipi and pembro individually (and also progressed on BRAF-MEK).  I've had a decent run (12 mos) on ipi-nivo.  While the response rate is lower for patients that have failed individual immunotherapy treatments (like me and you)–there is still a decent response rate.  Other benefits–no need to qualify for a trial, no wash-out period, no travel and no strict rules around steroid use for side effects.  Good luck.

I failed ipi and pembro individually (and also progressed on BRAF-MEK).  I've had a decent run (12 mos) on ipi-nivo.  While the response rate is lower for patients that have failed individual immunotherapy treatments (like me and you)–there is still a decent response rate.  Other benefits–no need to qualify for a trial, no wash-out period, no travel and no strict rules around steroid use for side effects.  Good luck.