Failed ipi nivo

First of all Hugs!
My mom is also in a similar situation,
We are starting a traditional chemo therapy, followed by Keytruda (also an anti-pdl1) like opdivo.

Our oncologist thinks that chemotherapy creates sort of tumor inflammation, and would enhance the response to another immunotherapy. He believes that chemo it self can also triggers solid regression on its own (not a huge probability, but we still would take it – who knows)

Meanwhile, I am searching clinical trials, I am particularly interested in TIL, some of our fellows here have experienced wonderful durable results.

Furthermore, how is the rest of her genetic profile?
She could still benefit from a targeted therapy that focuses on a non-melanoma deformed Gene – for example if she has the gene for breast cancer, she could benefit from a breast cancer targeted therapy, you may want to discuss that too with your doctor.

I would also recommend sending a direct message to our friend here MelanomaMike, or read his treatment history for ideas, he has almost tried every treatment on this planet, and he is doing very well inspiring all of us.

Finally, I know what you mean, do not tell her now, go ahead explore some options and talk to her doctors then get back to her with a good idea or two along with the (not so good) news.

Love,