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drugs that cross blood-brain barrier
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drugs that cross blood-brain barrier

› Forums › General Melanoma Community › drugs that cross blood-brain barrier

  • Post
    • August 23, 2012 at 10:36 pm
    triciad
    Participant

      Hi Everyone,

      I have a friend with brain mets.  Does anyone know which drugs cross the blood-brain barrier?

      Thanks so much for your help and keep up the fight!

      Tricia

      Hi Everyone,

      I have a friend with brain mets.  Does anyone know which drugs cross the blood-brain barrier?

      Thanks so much for your help and keep up the fight!

      Tricia

    Viewing 8 reply threads
    • Replies
        • August 24, 2012 at 12:03 am
        lhaley
        Participant

          zelboraf (must have the mutation)

          temedor (but not great for mel)

          some home found for yeryoy

           

          I don't know of any others, hoping some can add.    I start zelboraf tonight!

          Linda

          • August 24, 2012 at 12:03 am
          lhaley
          Participant

            zelboraf (must have the mutation)

            temedor (but not great for mel)

            some home found for yeryoy

             

            I don't know of any others, hoping some can add.    I start zelboraf tonight!

            Linda

              • August 24, 2012 at 1:17 am
              triciad
              Participant

                Linda,

                As always, thank you for your input.  Good luck with the Zelboraf.  You are constantly in my prayers.  You are a true warrior and I know you will do well with this new treatment.  God bless!!!

                Tricia

                • August 24, 2012 at 1:17 am
                triciad
                Participant

                  Linda,

                  As always, thank you for your input.  Good luck with the Zelboraf.  You are constantly in my prayers.  You are a true warrior and I know you will do well with this new treatment.  God bless!!!

                  Tricia

                  • August 24, 2012 at 1:17 am
                  triciad
                  Participant

                    Linda,

                    As always, thank you for your input.  Good luck with the Zelboraf.  You are constantly in my prayers.  You are a true warrior and I know you will do well with this new treatment.  God bless!!!

                    Tricia

                    • August 24, 2012 at 12:51 pm
                    Laurie from maine
                    Participant

                      I dont know much about it so cant help.  I only heard temedor also, or getting brain zapped if possible.

                      LINDA

                      I think of you and pray for you all the time  Good luck with zelboraf.  How are you doing?

                      laurie from maine

                      • August 24, 2012 at 12:58 pm
                      lhaley
                      Participant

                        I was supposed to go into a trial for brain mets with zelboraf (yesterday we decided to get off of the trial because it was taking too long to get into it – they were sending my biopsy that had been done too many years ago and were starting over).  The staticis are actually really good growith 83% response.  Of course it isn't sustatable.  They are looking into adding MEK on to try the brain also hopefully in the fall.  I think that you will have to be stable for 3 months.  At least there are changes even in the last few months!

                        I've done the gamma a few times and bleeding seems to be results for me – it does shrink but too many have started.  

                        Linda

                        • August 25, 2012 at 12:03 am
                        killmel
                        Participant

                          Hi Linda,

                           

                          I was so happy to see your post.

                          How are you doing?? What treatment did your decide on now that you are not going with zelboraf??

                          God BlessYou

                          MaryBeth

                          • August 25, 2012 at 12:03 am
                          killmel
                          Participant

                            Hi Linda,

                             

                            I was so happy to see your post.

                            How are you doing?? What treatment did your decide on now that you are not going with zelboraf??

                            God BlessYou

                            MaryBeth

                            • August 25, 2012 at 1:26 am
                            lhaley
                            Participant

                              I am doing Zelboraf just not on a trial.  Just took my 4 th time!   I'm glad that I was able to swallow those pills!  That was my first challange!   Found out that applesauce works!  They are weaning from the dex and so far so good!

                              Linda

                              • August 25, 2012 at 1:26 am
                              lhaley
                              Participant

                                I am doing Zelboraf just not on a trial.  Just took my 4 th time!   I'm glad that I was able to swallow those pills!  That was my first challange!   Found out that applesauce works!  They are weaning from the dex and so far so good!

                                Linda

                                • August 25, 2012 at 1:26 am
                                lhaley
                                Participant

                                  I am doing Zelboraf just not on a trial.  Just took my 4 th time!   I'm glad that I was able to swallow those pills!  That was my first challange!   Found out that applesauce works!  They are weaning from the dex and so far so good!

                                  Linda

                                  • August 25, 2012 at 12:03 am
                                  killmel
                                  Participant

                                    Hi Linda,

                                     

                                    I was so happy to see your post.

                                    How are you doing?? What treatment did your decide on now that you are not going with zelboraf??

                                    God BlessYou

                                    MaryBeth

                                    • August 24, 2012 at 12:58 pm
                                    lhaley
                                    Participant

                                      I was supposed to go into a trial for brain mets with zelboraf (yesterday we decided to get off of the trial because it was taking too long to get into it – they were sending my biopsy that had been done too many years ago and were starting over).  The staticis are actually really good growith 83% response.  Of course it isn't sustatable.  They are looking into adding MEK on to try the brain also hopefully in the fall.  I think that you will have to be stable for 3 months.  At least there are changes even in the last few months!

                                      I've done the gamma a few times and bleeding seems to be results for me – it does shrink but too many have started.  

                                      Linda

                                      • August 24, 2012 at 12:58 pm
                                      lhaley
                                      Participant

                                        I was supposed to go into a trial for brain mets with zelboraf (yesterday we decided to get off of the trial because it was taking too long to get into it – they were sending my biopsy that had been done too many years ago and were starting over).  The staticis are actually really good growith 83% response.  Of course it isn't sustatable.  They are looking into adding MEK on to try the brain also hopefully in the fall.  I think that you will have to be stable for 3 months.  At least there are changes even in the last few months!

                                        I've done the gamma a few times and bleeding seems to be results for me – it does shrink but too many have started.  

                                        Linda

                                        • August 24, 2012 at 12:51 pm
                                        Laurie from maine
                                        Participant

                                          I dont know much about it so cant help.  I only heard temedor also, or getting brain zapped if possible.

                                          LINDA

                                          I think of you and pray for you all the time  Good luck with zelboraf.  How are you doing?

                                          laurie from maine

                                          • August 24, 2012 at 12:51 pm
                                          Laurie from maine
                                          Participant

                                            I dont know much about it so cant help.  I only heard temedor also, or getting brain zapped if possible.

                                            LINDA

                                            I think of you and pray for you all the time  Good luck with zelboraf.  How are you doing?

                                            laurie from maine

                                          • August 24, 2012 at 12:03 am
                                          lhaley
                                          Participant

                                            zelboraf (must have the mutation)

                                            temedor (but not great for mel)

                                            some home found for yeryoy

                                             

                                            I don't know of any others, hoping some can add.    I start zelboraf tonight!

                                            Linda

                                            • August 24, 2012 at 1:08 pm
                                            Randy437
                                            Participant

                                              My oncs nurse told me Yervoy does cross the blood brain barrier.

                                              • August 24, 2012 at 1:08 pm
                                              Randy437
                                              Participant

                                                My oncs nurse told me Yervoy does cross the blood brain barrier.

                                                • August 24, 2012 at 1:08 pm
                                                Randy437
                                                Participant

                                                  My oncs nurse told me Yervoy does cross the blood brain barrier.

                                                  • August 25, 2012 at 4:45 am
                                                  Amanda
                                                  Participant

                                                    Yervoy crosses the blood brain barrier since the drug itself is not what is attacking the melanoma.  Yervoy unleashes the brakes on your immune system to let your T-cells attack the melanoma.  Your t-cells are part of your own body so yes, Yervoy can kill melanoma in the brain. 

                                                    • August 25, 2012 at 4:45 am
                                                    Amanda
                                                    Participant

                                                      Yervoy crosses the blood brain barrier since the drug itself is not what is attacking the melanoma.  Yervoy unleashes the brakes on your immune system to let your T-cells attack the melanoma.  Your t-cells are part of your own body so yes, Yervoy can kill melanoma in the brain. 

                                                      • August 25, 2012 at 4:45 am
                                                      Amanda
                                                      Participant

                                                        Yervoy crosses the blood brain barrier since the drug itself is not what is attacking the melanoma.  Yervoy unleashes the brakes on your immune system to let your T-cells attack the melanoma.  Your t-cells are part of your own body so yes, Yervoy can kill melanoma in the brain. 

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