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Any recent stage 2 (or 3) patients with current experience regarding depigmentation / vitiligo around atypical nevus ?
Have had a 1/4" pink nodule / bump "puff up" in a depigmented area. Bump sloughed a layer and has started to recede. Similar pattern as a prior melanoma with ulceration / regression (came, went, came back). Biopsy scheduled for this coming week.
I've read some encouraging articles that depigmentation may be favorable from an immuno response perspective, but want to get on this in the event of regression and reduced ability to correctly gauge depth (2015 experience).
Thank you for any personal experiences regarding depigmentation prior (important) to beginning immunotherapy.
Hi Jamie, this is the first time I have seen this question (very interesting), while I have never seen anything associated with Vitiligo other than in response to Immunotherapy treatment ( Ipi, or Pd-1 drugs). Dr. Weber talks about Vitiligo research in the following video at the 31:30 mark. https://www.youtube.com/watch?v=ysbSCeqJpq0 Best Wishes!!!Ed
Biopsy off to the lab today; given the pattern of appearance and spontaneous regression in the same place, along with spreading margin of de-pigmented skin, my guess is basal cell, possibly morpheic.
My dermatologist, Bonnie Epstein (JHU), has a very good eye and did not think the lesion itself was particularly remarkable; she did agree that the surrounding area with a clear loss of pigment did indicate that the body was attempting to destroy something and the only "something" visible in the area was the small, regressing bump.
Will post an update once results are back – if only anecdotal, it will be interesting to see if T cell activity / pigmentation loss is a predictor of anything.
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