› Forums › General Melanoma Community › Decision factors on randomized trial
- This topic has 24 replies, 6 voices, and was last updated 10 years, 5 months ago by kpcollins31.
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- November 16, 2013 at 2:56 pm
My husband is stage three, currently recovering from surgery to remove a melanoma on his foot and eight lymph glands. Six of the glands had been completely taken over by cancerous tissue. We are told chance of recurrence is 50%. Iam thinking this may be low, given the level of involvement.
We are waiting to learn if he has BRAF gene and could be eligible for that trial.
otherwise, our doctor has told us we are eligible for a randomized interferon/ipi trial. We have read that interferon is not effective, and has many side effects, some know my husband is considering watch and wait, vs a randomized trial.
it is a difficult time,mdifficult decision. I am interested I hearing decision factors and experiences of others.
i also see there are other trials, something called IL2? I will ask our doctor about these.
thank you for thoughts and sharing!
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- November 16, 2013 at 3:10 pm
Hello!
My mom was stage 3 and choose to skip the ipi/ interferon trial due to the fact that she didn't want the chance of getting interferon which appears not to be effective and the side effects are horrible. She had melanoma in her foot and 5 nodes positive. She is now on the pd1/ ipi trial since she did become stage 4. Every situation is different but make sure to get second opinions by top melanoma drs.
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- November 16, 2013 at 3:10 pm
Hello!
My mom was stage 3 and choose to skip the ipi/ interferon trial due to the fact that she didn't want the chance of getting interferon which appears not to be effective and the side effects are horrible. She had melanoma in her foot and 5 nodes positive. She is now on the pd1/ ipi trial since she did become stage 4. Every situation is different but make sure to get second opinions by top melanoma drs.
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- November 16, 2013 at 3:56 pm
Hi Michele,
i was diagnosed with stage III a disease. After having the lymph does removed as a follow up, I too passed on interferon. I did get on a clinical trial (10-229 Dendritic/Langerhans cell vaccine). I found the NIH site very easy to use and look up clinical trials appropriate for your husband's stage/type, etc. I am being treated at Sloan Kettering in NY and you wil find some of the larger cancer hospitals will be test sites for some of these new trials. Hope that helps and good luck!
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- November 16, 2013 at 3:56 pm
Hi Michele,
i was diagnosed with stage III a disease. After having the lymph does removed as a follow up, I too passed on interferon. I did get on a clinical trial (10-229 Dendritic/Langerhans cell vaccine). I found the NIH site very easy to use and look up clinical trials appropriate for your husband's stage/type, etc. I am being treated at Sloan Kettering in NY and you wil find some of the larger cancer hospitals will be test sites for some of these new trials. Hope that helps and good luck!
-
- November 16, 2013 at 3:56 pm
Hi Michele,
i was diagnosed with stage III a disease. After having the lymph does removed as a follow up, I too passed on interferon. I did get on a clinical trial (10-229 Dendritic/Langerhans cell vaccine). I found the NIH site very easy to use and look up clinical trials appropriate for your husband's stage/type, etc. I am being treated at Sloan Kettering in NY and you wil find some of the larger cancer hospitals will be test sites for some of these new trials. Hope that helps and good luck!
-
- November 16, 2013 at 3:10 pm
Hello!
My mom was stage 3 and choose to skip the ipi/ interferon trial due to the fact that she didn't want the chance of getting interferon which appears not to be effective and the side effects are horrible. She had melanoma in her foot and 5 nodes positive. She is now on the pd1/ ipi trial since she did become stage 4. Every situation is different but make sure to get second opinions by top melanoma drs.
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- November 17, 2013 at 5:09 am
Can't he go into the trial and then drop out if he is chosen for interpheron. Or is that considered bad form.
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- November 17, 2013 at 1:17 pm
Yes and yes. But even if you withdraw, it's unlikely to have consequences unless your oncologist has problems with you doing this. It does cost a lot of money to run trials and they really do want people who plan to participate with the study and how it is designed. If your onc is the study doc, he may have problems if you plan this going in.
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- November 17, 2013 at 1:17 pm
Yes and yes. But even if you withdraw, it's unlikely to have consequences unless your oncologist has problems with you doing this. It does cost a lot of money to run trials and they really do want people who plan to participate with the study and how it is designed. If your onc is the study doc, he may have problems if you plan this going in.
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- November 17, 2013 at 1:17 pm
Yes and yes. But even if you withdraw, it's unlikely to have consequences unless your oncologist has problems with you doing this. It does cost a lot of money to run trials and they really do want people who plan to participate with the study and how it is designed. If your onc is the study doc, he may have problems if you plan this going in.
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- November 18, 2013 at 10:06 pm
I was in a similar situation when I progressed to stage 3C a year and a half ago. I chose watch and wait over the interferon vs ipi trial. My thought process was similar to yours – I was not willing to take the risk of being randomized into the interferon arm. I am comfortable with my decision. Good luck with yours.
Kevin
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- November 18, 2013 at 10:06 pm
I was in a similar situation when I progressed to stage 3C a year and a half ago. I chose watch and wait over the interferon vs ipi trial. My thought process was similar to yours – I was not willing to take the risk of being randomized into the interferon arm. I am comfortable with my decision. Good luck with yours.
Kevin
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- November 18, 2013 at 10:06 pm
I was in a similar situation when I progressed to stage 3C a year and a half ago. I chose watch and wait over the interferon vs ipi trial. My thought process was similar to yours – I was not willing to take the risk of being randomized into the interferon arm. I am comfortable with my decision. Good luck with yours.
Kevin
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